{"id":28427,"date":"2025-07-03T13:46:34","date_gmt":"2025-07-03T11:46:34","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/pachet-complet-trombofilie-ereditara-si-dobandita\/"},"modified":"2026-03-24T14:12:14","modified_gmt":"2026-03-24T12:12:14","slug":"pachet-complet-trombofilie-ereditara-si-dobandita","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/pachete\/pachet-complet-trombofilie-ereditara-si-dobandita\/","title":{"rendered":"Profil complet trombofilie (ereditara si dobandita)"},"content":{"rendered":"<h3 class=\"\"><b><span style=\"color: #ff9c00;\">Ce include:<br \/>\n<\/span><\/b><\/h3>\n<p><b>Factori de trombofilie dob\u00e2ndit\u0103 (sindrom antifosfolipidic \/ mecanism autoimun):<\/b><\/p>\n<ul>\n<li><b>Anticoagulant lupic (dRVVT Screen)<\/b> \u2013 test de screening pentru prezen\u021ba anticoagulantului lupic, asociat cu risc crescut de tromboz\u0103 venoas\u0103\/arterial\u0103 \u0219i complica\u021bii de sarcin\u0103, \u00een cadrul sindromului antifosfolipidic.<\/li>\n<li><b>Anticorpi anti-beta-2-glicoproteina I IgG<\/b> \u2013 autoanticorpi \u00eendrepta\u021bi \u00eempotriva beta-2-glicoproteinei I; marker important \u00een suspiciunea de APS.<\/li>\n<li><b>Anticorpi anti-beta-2-glicoproteina I IgM<\/b> \u2013 completeaz\u0103 evaluarea serologic\u0103 \u00een suspiciunea de APS, al\u0103turi de izotipul IgG.<\/li>\n<li><b> Anticorpi anticardiolipinici IgG<\/b> \u2013 anticorpi antifosfolipidici asocia\u021bi cu risc trombotic \u0219i complica\u021bii obstetricale \u00een APS.<\/li>\n<li><b>Anticorpi anticardiolipinici IgM<\/b> \u2013 completeaz\u0103 evaluarea anticorpilor anticardiolipinici \u00een suspiciunea de APS.<\/li>\n<li><b>D-dimeri<\/b> \u2013 produs de degradare al fibrinei; valori crescute pot ap\u0103rea \u00een contexte cu activare trombotic\u0103 recent\u0103, dar nu sunt specifice (interpretarea se face \u00een context clinic).<\/li>\n<\/ul>\n<p><b>Factori de trombofilie ereditar\u0103 (trombofilie genetic\u0103 \/ deficite congenitale):<\/b><\/p>\n<ul>\n<li><b>Antitrombina III<\/b> \u2013 inhibitor natural al trombinei \u0219i al altor factori de coagulare; deficitul congenital cre\u0219te semnificativ riscul de tromboz\u0103 venoas\u0103.<\/li>\n<li><b>Proteina C<\/b> \u2013 protein\u0103 dependent\u0103 de vitamina K, cu rol anticoagulant; deficitul congenital sau dob\u00e2ndit poate fi asociat cu episoade trombotice.<\/li>\n<li><b>Free Proteina S (proteina S liber\u0103) <\/b>\u2013 cofactor al proteinei C; deficitul reduce controlul natural al coagul\u0103rii \u0219i favorizeaz\u0103 formarea cheagurilor.<\/li>\n<\/ul>\n<p><b>Factori genetici de risc pentru trombofilie \u2013 determinare prin RT-PCR:<\/b><\/p>\n<ul>\n<li><b>Muta\u021bia factorului V Leiden (FV R506Q)<\/b> \u2013 asociat\u0103 cu rezisten\u021b\u0103 la proteina C activat\u0103 \u0219i risc crescut de tromboz\u0103 venoas\u0103.<\/li>\n<li><b>Muta\u021bia factorului II (protrombina G20210A)<\/b> \u2013 asociat\u0103 cu niveluri crescute de protrombin\u0103 \u0219i risc trombotic crescut.<\/li>\n<li><b>MTHFR (C677T \/ A1298C) <\/b>\u2013 variante genetice implicate \u00een metabolismul folatului; pot contribui la cre\u0219terea homocisteinei, mai ales \u00een asociere cu deficit de folat\/B12.<\/li>\n<li><b>PAI-1 4G\/5G<\/b> \u2013 variant\u0103 genetic\u0103 a genei PAI-1 (plasminogen activator inhibitor 1) ce poate influen\u021ba fibrinoliza (dizolvarea cheagurilor), cu relevan\u021b\u0103 \u00een anumite contexte clinice.<\/li>\n<li><b>Factor XIII<\/b> \u2013 implicat \u00een stabilizarea cheagului de fibrin\u0103; anumite variante genetice pot modula riscul trombotic.<\/li>\n<\/ul>\n<h3 class=\"\"><b><span style=\"color: #ff9c00;\">Recomand\u0103ri pentru testare<\/span><\/b><span style=\"font-size: 1.9vh;\"><br \/>\n<\/span><\/h3>\n<h3 class=\"\"><span style=\"font-size: 14px;\"><b>Profilul complet de trombofilie este recomandat, \u00een general, la indica\u021bia medicului, \u00een urm\u0103toarele situa\u021bii:<\/b><\/span><\/h3>\n<ul>\n<li>Tromboz\u0103 venoas\u0103 profund\u0103 sau embolie pulmonar\u0103, mai ales la v\u00e2rst\u0103 t\u00e2n\u0103r\u0103, \u00een absen\u021ba unor factori de risc eviden\u021bi sau \u00een cazul episoadelor repetate.<\/li>\n<li>Evenimente trombotice arteriale (de exemplu infarct miocardic, accident vascular cerebral, ischemii periferice) la persoane tinere sau f\u0103r\u0103 factori de risc cardiovascular clari, c\u00e2nd se suspecteaz\u0103 un mecanism trombofilic\/autoimun.<\/li>\n<li>Avorturi spontane recurente, moarte fetal\u0103 intrauterin\u0103, preeclampsie sever\u0103, restric\u021bie sever\u0103 de cre\u0219tere intrauterin\u0103 sau alte complica\u021bii de sarcin\u0103 \u00een care se suspecteaz\u0103 trombofilie \u0219i\/sau sindrom antifosfolipidic.<\/li>\n<li>Suspiciune clinic\u0103 de sindrom antifosfolipidic (tromboze \u0219i\/sau complica\u021bii obstetricale asociate cu teste de laborator pozitive), inclusiv \u00een contextul unor boli autoimune.<\/li>\n<li>Istoric personal sau familial sugestiv de trombofilie \u0219i necesitatea unei evalu\u0103ri complete \u00eenainte de sarcin\u0103, tratamente hormonale sau interven\u021bii chirurgicale majore.<\/li>\n<\/ul>\n<h3 class=\"\"><b><span style=\"color: #ff9c00;\">Preg\u0103tire pacient<\/span><\/b><\/h3>\n<ul>\n<li>Recoltarea se efectueaz\u0103, de obicei, diminea\u021ba, din s\u00e2nge venos; se prefer\u0103 un repaus alimentar de 8\u201312 ore (apa este permis\u0103), pentru standardizarea recolt\u0103rii.<\/li>\n<li>Unele determin\u0103ri func\u021bionale (antitrombina III, proteinele C \u0219i S, D-dimeri, anticoagulant lupic \u0219i anticorpi antifosfolipidici) pot fi influen\u021bate de tratamentul anticoagulant\/antiagregant, de un episod trombotic recent, de sarcin\u0103, boli acute\/inflamatorii sau afec\u021biuni hepatice\/renale; momentul optim al test\u0103rii se stabile\u0219te \u00eempreun\u0103 cu medicul curant.<\/li>\n<li>Testele genetice se efectueaz\u0103 o singur\u0103 dat\u0103 \u00een via\u021b\u0103, deoarece materialul genetic nu se modific\u0103; interpretarea rezultatelor se face \u00een context medical.<\/li>\n<\/ul>\n<p><b><span style=\"color: #ff9c00;\">Tip prob\u0103 recoltat\u0103:<\/span><\/b> s\u00e2nge venos.<br \/>\n.<br \/>\n<b><br \/>\n<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"<p><b>Trombofilia <\/b>reprezint\u0103 tendin\u021ba crescut\u0103 de a forma cheaguri de s\u00e2nge (trombi), ca urmare a unui dezechilibru \u00eentre mecanismele care favorizeaz\u0103 coagularea \u0219i cele care o controleaz\u0103. Cheagurile apar cel mai frecvent \u00een sistemul venos (tromboz\u0103 venoas\u0103 profund\u0103) \u0219i pot migra c\u0103tre pl\u0103m\u00e2ni (embolie pulmonar\u0103). \u00cen anumite situa\u021bii, trombofilia se poate asocia \u0219i cu complica\u021bii de sarcin\u0103, prin afectarea circula\u021biei placentare.<\/p>\n<p>Acest profil complet reune\u0219te at\u00e2t markerii de trombofilie ereditar\u0103 (deficite ale proteinelor anticoagulante naturale \u0219i muta\u021bii genetice cu risc trombotic), c\u00e2t \u0219i markerii de trombofilie dob\u00e2ndit\u0103, \u00een special cei pentru evaluarea sindromului antifosfolipidic (APS). \u00cen plus, include D-dimerii, marker util pentru aprecierea activ\u0103rii recente a coagul\u0103rii \u0219i fibrinolizei, \u00een context clinic adecvat.<\/p>\n<p>Rezultatele se interpreteaz\u0103 de c\u0103tre medic (hematolog, cardiolog, angiolog, ginecolog, reumatolog), \u00een contextul manifest\u0103rilor clinice \u0219i al factorilor de risc asocia\u021bi (imobilizare prelungit\u0103, interven\u021bii chirurgicale, sarcin\u0103, tratamente hormonale, fumat, obezitate). \u00cen cazul suspiciunii de APS, confirmarea diagnosticului poate necesita repetarea determin\u0103rilor la intervalul recomandat de medic.<\/p>\n","protected":false},"featured_media":28635,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[3093,3094],"product_tag":[],"class_list":{"0":"post-28427","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-pachete","7":"product_cat-pachete-de-analize-medicale","8":"pa_conditii-medicale-afecti-boala-vasculara-periferica-venoasa-arteriala","9":"pa_conditii-medicale-afecti-insuficienta-hepatica-ciroza-hepatica","10":"pa_conditii-medicale-afecti-istoric-de-accident-vascular-cerebral-avc","11":"pa_conditii-medicale-afecti-lupus-eritematos-sistemic","12":"pa_conditii-medicale-afecti-tulburari-de-coagulare-trombofilie-hemofilie","13":"pa_parti-ale-corpului-organ-ficat-si-colecist","15":"first","16":"instock","17":"sale","18":"virtual","19":"purchasable","20":"product-type-simple"},"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product\/28427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/media\/28635"}],"wp:attachment":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/media?parent=28427"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_brand?post=28427"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_cat?post=28427"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_tag?post=28427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}