{"id":27688,"date":"2025-06-24T16:49:08","date_gmt":"2025-06-24T13:49:08","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/panel-imunohistochimie-ihc-mmr-msi-endometru-mlh1-msh1-msh6-pms2-p53\/"},"modified":"2026-06-16T11:26:24","modified_gmt":"2026-06-16T08:26:24","slug":"panel-imunohistochimie-ihc-mmr-msi-endometru-mlh1-msh1-msh6-pms2-p53","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-anatomie-patologica\/panel-imunohistochimie-ihc-mmr-msi-endometru-mlh1-msh1-msh6-pms2-p53\/","title":{"rendered":"Panel imunohistochimie &#8211; IHC MMR\/MSI endometru (MLH1, MSH2, MSH6, PMS2) +\/- p53"},"content":{"rendered":"<p>Acest panel imunohistochimic evalueaz\u0103 statusul sistemului de reparare a ADN-ului (MMR \u2013 mismatch repair), un mecanism fundamental pentru men\u021binerea stabilit\u0103\u021bii genetice.<\/p>\n<h3>Markerii analiza\u021bi sunt:<\/h3>\n<ul>\n<li>MLH1<\/li>\n<li>MSH2<\/li>\n<li>MSH6<\/li>\n<li>PMS2<\/li>\n<\/ul>\n<p>Pierderea expresiei uneia sau mai multor proteine indic\u0103 deficit al sistemului MMR (dMMR), asociat frecvent cu instabilitate microsatelitar\u0103 (MSI-H).<\/p>\n<p>\u00cen cancerul endometrial, acest panel are o importan\u021b\u0103 major\u0103 at\u00e2t pentru stratificarea prognostic\u0103, c\u00e2t \u0219i pentru identificarea pacientelor cu suspiciune de sindrom Lynch (cancer ereditar).<\/p>\n<p>Markerul p53 poate fi ad\u0103ugat pentru o evaluare suplimentar\u0103 a alter\u0103rilor genomice, fiind util \u00een clasificarea molecular\u0103 a carcinomului endometrial \u0219i \u00een diferen\u021bierea subtipurilor agresive.<\/p>\n<h3>Afec\u021biuni sau simptome asociate<\/h3>\n<h3>Testul este utilizat \u00een:<\/h3>\n<ul>\n<li>Cancer endometrial (carcinom de endometru)<\/li>\n<li>Hiperplazie endometrial\u0103 atipic\u0103<\/li>\n<li>Suspiciune de sindrom Lynch<\/li>\n<li>Tumori ginecologice asociate MSI-H<\/li>\n<li>Neoplazii endometriale cu comportament agresiv<\/li>\n<li>Evaluare molecular\u0103 pentru clasificarea cancerului uterin<\/li>\n<\/ul>\n<h3>Cui se adreseaz\u0103<\/h3>\n<h3>Testarea se adreseaz\u0103:<\/h3>\n<ul>\n<li>Pacientelor cu cancer endometrial nou diagnosticat<\/li>\n<li>Pacientelor tinere cu carcinom endometrial<\/li>\n<li>Pacientelor cu istoric familial de cancer colorectal sau endometrial<\/li>\n<li>Cazurilor suspecte de sindrom Lynch<\/li>\n<li>Medicilor ginecologi oncologi pentru stratificare terapeutic\u0103<\/li>\n<li>Medicilor anatomopatologi pentru clasificare molecular\u0103<\/li>\n<\/ul>\n<h3>Metodologie de testare<\/h3>\n<ol>\n<li>Se selecteaz\u0103 blocul de parafin\u0103 (FFPE) reprezentativ endometrial<\/li>\n<li>Se realizeaz\u0103 sec\u021biuni histologice fine<\/li>\n<li>Se aplic\u0103 anticorpi pentru MLH1, MSH2, MSH6, PMS2 \u00b1 p53<\/li>\n<li>Se eviden\u021biaz\u0103 expresia nuclear\u0103 a proteinelor MMR<\/li>\n<li>Se identific\u0103 pierderea sau conservarea expresiei markerilor<\/li>\n<li>Se coreleaz\u0103 rezultatele \u00eentre ele \u0219i cu morfologia tumorii<\/li>\n<li>Se emite raportul imunohistochimic final<\/li>\n<\/ol>\n<h3>Beneficii \u0219i importan\u021ba clinic\u0103<\/h3>\n<ul>\n<li>Identific\u0103 instabilitatea microsatelitar\u0103 (MSI-H)<\/li>\n<li>Ajut\u0103 la diagnosticarea sindromului Lynch<\/li>\n<li>Ofer\u0103 informa\u021bii prognostice importante \u00een cancerul endometrial<\/li>\n<li>Contribuie la clasificarea molecular\u0103 a carcinomului uterin<\/li>\n<li>Ghideaz\u0103 deciziile terapeutice personalizate<\/li>\n<li>Poate influen\u021ba indica\u021bia pentru imunoterapie<\/li>\n<li>Sprijin\u0103 screeningul familial \u00een cazurile ereditare<\/li>\n<\/ul>\n<h3>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/h3>\n<h3>Particularit\u0103\u021bi<\/h3>\n<ul>\n<li>Reprezint\u0103 un marker molecular esen\u021bial \u00een cancerul endometrial<\/li>\n<li>Este inclus \u00een clasific\u0103rile moderne OMS \u0219i TCGA<\/li>\n<li>Permite diferen\u021bierea subtipurilor moleculare de cancer uterin<\/li>\n<li>Poate fi completat de teste genetice pentru confirmare<\/li>\n<\/ul>\n<h3>Limit\u0103ri<\/h3>\n<ul>\n<li>Nu toate cazurile MSI sunt identificate exclusiv prin IHC<\/li>\n<li>Poate necesita confirmare molecular\u0103 (PCR\/NGS)<\/li>\n<li>Heterogenitatea tumoral\u0103 poate influen\u021ba expresia markerilor<\/li>\n<li>Depinde de calitatea fix\u0103rii \u0219i a probei tisulare<\/li>\n<\/ul>\n<h3>Indica\u021bii de testare<\/h3>\n<ul>\n<li>Cancer endometrial nou diagnosticat<\/li>\n<li>Tumori uterine cu histologie agresiv\u0103 sau neclar\u0103<\/li>\n<li>Suspiciune de sindrom Lynch<\/li>\n<li>Paciente tinere cu carcinom endometrial<\/li>\n<li>Istoric familial sugestiv pentru cancer ereditar<\/li>\n<li>Stratificare molecular\u0103 \u00een cancerul de endometru<\/li>\n<li>Decizie terapeutic\u0103 (inclusiv imunoterapie)<\/li>\n<\/ul>\n<h3>Interpretarea rezultatelor<\/h3>\n<h3>Sistem MMR intact (pMMR)<\/h3>\n<ul>\n<li>Expresie nuclear\u0103 p\u0103strat\u0103 pentru toate proteinele MMR<\/li>\n<li>Sugereaz\u0103 stabilitate microsatelitar\u0103 (MSS)<\/li>\n<\/ul>\n<h3>Deficit MMR (dMMR)<\/h3>\n<ul>\n<li>Pierdere de expresie pentru una sau mai multe proteine<\/li>\n<li>Sugereaz\u0103 instabilitate microsatelitar\u0103 (MSI-H)<\/li>\n<li>Necesit\u0103 evaluare suplimentar\u0103 pentru stabilirea cauzei (sporadic\u0103 sau ereditar\u0103)<\/li>\n<\/ul>\n<h3>p53 (dac\u0103 este inclus)<\/h3>\n<ul>\n<li>Expresie normal\u0103 sau modificat\u0103 (pattern mutant)<\/li>\n<li>Ajut\u0103 la clasificarea molecular\u0103 (ex. tipuri agresive seroase vs endometrioide)<\/li>\n<\/ul>\n<p>Interpretarea final\u0103 este realizat\u0103 de medicul anatomopatolog \u00een corela\u021bie cu datele clinice, histologice \u0219i eventual genetice.<\/p>\n<h3>Raportarea conform ghidurilor<\/h3>\n<ul>\n<li>Clasificarea OMS a tumorilor ginecologice<\/li>\n<li>Ghidurile ESGO\/ESTRO\/ESP pentru cancer endometrial<\/li>\n<li>Recomand\u0103rile NCCN pentru cancer uterin<\/li>\n<li>Protocoale interna\u021bionale pentru testarea MMR\/MSI<\/li>\n<li>Ghiduri pentru identificarea sindromului Lynch<\/li>\n<\/ul>\n<h3>Factori care pot influen\u021ba rezultatul<\/h3>\n<ul>\n<li>Fixarea \u00eent\u00e2rziat\u0103 a \u021besutului<\/li>\n<li>Necroza tumoral\u0103<\/li>\n<li>Calitatea blocului FFPE<\/li>\n<li>Heterogenitatea expresiei proteice<\/li>\n<li>Artefacte de procesare histologic\u0103<\/li>\n<li>Timpul p\u00e2n\u0103 la fixare<\/li>\n<\/ul>\n<h3>Condi\u021bii pentru recoltare<\/h3>\n<ul>\n<li>Recoltare prin biopsie endometrial\u0103 sau pies\u0103 operatorie<\/li>\n<li>Fixare imediat\u0103 \u00een formalin\u0103 tamponat\u0103 10%<\/li>\n<li>Evitarea \u00eent\u00e2rzierii \u00eentre recoltare \u0219i fixare<\/li>\n<\/ul>\n<h3>Specimen de recoltare<\/h3>\n<ul>\n<li>\u021aesut endometrial inclus \u00een parafin\u0103 (FFPE)<\/li>\n<li>Biopsii endometriale sau piese chirurgicale uterine<\/li>\n<\/ul>\n<h3>Prob\u0103<\/h3>\n<ul>\n<li>Blocuri de parafin\u0103 (FFPE) reprezentative<\/li>\n<li>Lame histologice dac\u0103 sunt solicitate<\/li>\n<\/ul>\n<h3>Stabilitate<\/h3>\n<ul>\n<li>Blocurile FFPE sunt stabile pe termen lung<\/li>\n<li>Calitatea antigenic\u0103 depinde de fixare \u0219i condi\u021bii de p\u0103strare<\/li>\n<li>Materialul vechi poate avea expresie redus\u0103 a antigenelor<\/li>\n<\/ul>\n<h3>Analize asociate recomandate<\/h3>\n<ul>\n<li>Testare MSI molecular\u0103 (PCR sau NGS)<\/li>\n<li>Panel genetic pentru sindrom Lynch (germinal)<\/li>\n<li>Examen histopatologic standard<\/li>\n<li>p53 extins \u00een clasificarea molecular\u0103 endometrial\u0103<\/li>\n<li>POLE muta\u021bii (clasificare molecular\u0103 avansat\u0103)<\/li>\n<li>Profil molecular tumoral (NGS)<\/li>\n<li>PD-L1 (\u00een cazuri selectate pentru imunoterapie)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Panelul imunohistochimic MMR\/MSI pentru endometru este o analiz\u0103 utilizat\u0103 pentru evaluarea sistemului de reparare a erorilor ADN (Mismatch Repair \u2013 MMR) \u00een cancerul endometrial. Include markerii MLH1, MSH2, MSH6 \u0219i PMS2, cu posibilitatea ad\u0103ug\u0103rii p53 pentru caracterizare molecular\u0103 suplimentar\u0103. Testul este esen\u021bial pentru identificarea instabilit\u0103\u021bii microsatelitare (MSI) \u0219i pentru evaluarea pacientelor cu suspiciune de sindrom Lynch.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3168,2876],"product_tag":[],"class_list":["post-27688","product","type-product","status-publish","product_cat-analize","product_cat-anatomie-patologica","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Panel imunohistochimie IHC MMR\/MSI endometru (MLH1, MSH2, MSH6, PMS2, p53) \u2013 analiz\u0103 utilizat\u0103 \u00een evaluarea modific\u0103rilor moleculare asociate cancerului endometrial. 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