{"id":27659,"date":"2025-06-24T16:47:40","date_gmt":"2025-06-24T13:47:40","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/centoarray-cyto-arraycgh-prenatal-cariotip-molecular-prenatal\/"},"modified":"2026-10-21T19:40:47","modified_gmt":"2026-10-21T16:40:47","slug":"centoarray-cyto-arraycgh-prenatal-cariotip-molecular-prenatal","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-genetica-in-sarcina\/centoarray-cyto-arraycgh-prenatal-cariotip-molecular-prenatal\/","title":{"rendered":"CentoArray Cyto &#8211; ArrayCGH prenatal (cariotip molecular prenatal)"},"content":{"rendered":"<p>CentoArray Cyto este o analiz\u0103 genomic\u0103 prenatal\u0103 bazat\u0103 pe tehnologia de hibridizare genomic\u0103 comparativ\u0103 (array-CGH), utilizat\u0103 pentru evaluarea dezechilibrelor cromozomiale submicroscopice la nivelul \u00eentregului genom fetal.<\/p>\n<p>Testul compar\u0103 ADN-ul fetal (ob\u021binut din lichid amniotic sau vilozit\u0103\u021bi coriale) cu un ADN de referin\u021b\u0103, permi\u021b\u00e2nd identificarea varia\u021biilor de num\u0103r de copii (CNV), respectiv pierderi sau c\u00e2\u0219tiguri de material genetic.<\/p>\n<p>Metoda ofer\u0103 o rezolu\u021bie mult superioar\u0103 cariotipului conven\u021bional \u0219i este indicat\u0103 \u00een special \u00een sarcini cu suspiciune de anomalii genetice structurale sau anomalii de dezvoltare fetal\u0103.<\/p>\n<h3>Afec\u021biuni sau riscuri genetice investigate:<\/h3>\n<ul>\n<li>Microdele\u021bii \u0219i microduplica\u021bii cromozomiale;<\/li>\n<li>Sindroame genetice cauzate de varia\u021bii de num\u0103r de copii (CNV);<\/li>\n<li>Anomalii cromozomiale submicroscopice asociate cu malforma\u021bii fetale;<\/li>\n<li>Tulbur\u0103ri de dezvoltare neurocognitiv\u0103 cu origine cromozomial\u0103;<\/li>\n<li>Sindroame polimalformative fetale;<\/li>\n<li>Anomalii genetice asociate cu rezultate ecografice anormale;<\/li>\n<li>Unele aneuploidii \u0219i dezechilibre cromozomiale detectabile la nivel genomic.<\/li>\n<\/ul>\n<h3>Cui se adreseaz\u0103:<\/h3>\n<p>Medicilor ginecologi, speciali\u0219tilor \u00een medicin\u0103 materno-fetal\u0103, geneticienilor medicali \u0219i consilierilor genetici care gestioneaz\u0103 sarcini cu risc genetic crescut, istoric familial sugestiv sau anomalii ecografice fetale.<\/p>\n<h3>Metodologie de testare:<\/h3>\n<h3>Analiz\u0103 prin hibridizare genomic\u0103 comparativ\u0103 (array-CGH) efectuat\u0103 pe ADN fetal extras din:<\/h3>\n<ul>\n<li>lichid amniotic (amniocentez\u0103) sau<\/li>\n<li>vilozit\u0103\u021bi coriale (biopsie de trofoblast)<\/li>\n<\/ul>\n<h3>Tehnologia permite detectarea varia\u021biilor de tip:<\/h3>\n<ul>\n<li>dele\u021bii (pierdere de material genetic)<\/li>\n<li>duplica\u021bii (c\u00e2\u0219tig de material genetic)<\/li>\n<li>dezechilibre cromozomiale submicroscopice (CNV)<\/li>\n<\/ul>\n<h3>Beneficii \u0219i importan\u021b\u0103 clinic\u0103:<\/h3>\n<ul>\n<li>Detecteaz\u0103 anomalii cromozomiale invizibile la cariotipul clasic;<\/li>\n<li>Cre\u0219te semnificativ rata de diagnostic genetic prenatal;<\/li>\n<li>Ofer\u0103 informa\u021bii esen\u021biale pentru prognosticul fetal;<\/li>\n<li>Sprijin\u0103 deciziile clinice \u00een sarcini cu risc crescut;<\/li>\n<li>Permite identificarea cauzei genetice \u00een anomalii ecografice;<\/li>\n<li>Reduce necesitatea testelor genetice multiple secven\u021biale.<\/li>\n<\/ul>\n<h3>Particularit\u0103\u021bi \u0219i limit\u0103ri:<\/h3>\n<ul>\n<li>Nu detecteaz\u0103 muta\u021bii punctiforme (SNV) sau modific\u0103ri de o singur\u0103 liter\u0103 genetic\u0103;<\/li>\n<li>Nu identific\u0103 rearanjamente cromozomiale echilibrate (ex. transloca\u021bii echilibrate);<\/li>\n<li>Nu detecteaz\u0103 \u00een mod optim triploidia\/poliploidia \u00een toate cazurile;<\/li>\n<li>Poate genera variante cu semnifica\u021bie incert\u0103 (VUS) ce necesit\u0103 interpretare clinic\u0103;<\/li>\n<li>Rezultatul trebuie corelat cu ecografia \u0219i contextul clinic.<\/li>\n<\/ul>\n<h3>Tip prob\u0103:<\/h3>\n<ul>\n<li>Lichid amniotic<\/li>\n<li>Vilozit\u0103\u021bi coriale (biopsie de trofoblast)<\/li>\n<\/ul>\n<h3>Recoltare:<\/h3>\n<p>Recoltarea se realizeaz\u0103 \u00een condi\u021bii sterile prin proceduri obstetricale standard (amniocentez\u0103 sau biopsie de vilozit\u0103\u021bi coriale), de c\u0103tre medic specialist, cu transport rapid al probei c\u0103tre laboratorul de genetic\u0103.<\/p>\n<h3>Condi\u021bii:<\/h3>\n<p>Calitatea ADN-ului fetal este esen\u021bial\u0103 pentru acurate\u021bea analizei. Contaminarea matern\u0103 sau degradarea probei poate influen\u021ba sensibilitatea testului \u0219i interpretarea rezultatelor.<\/p>\n<h3>Denumiri alternative:<\/h3>\n<p>Cariotip molecular prenatal;<\/p>\n<p>Array-CGH prenatal;<\/p>\n<p>Analiz\u0103 CNV fetal\u0103;<\/p>\n<p>Test genetic prenatal de rezolu\u021bie \u00eenalt\u0103;<\/p>\n<p>CentoArray prenatal.<\/p>\n<h3>Analize asociate recomandate:<\/h3>\n<ul>\n<li>Cariotip fetal clasic pentru anomalii cromozomiale majore;<\/li>\n<li>Test NIPT (screening non-invaziv prenatal);<\/li>\n<li>Microarray sau WES parental pentru interpretarea variantelor mo\u0219tenite;<\/li>\n<li>Testare genetic\u0103 \u021bintit\u0103 (dac\u0103 exist\u0103 suspiciune specific\u0103);<\/li>\n<li>Ecografie morfologic\u0103 fetal\u0103 detaliat\u0103 \u0219i monitorizare serial\u0103;<\/li>\n<li>Consiliere genetic\u0103 prenatal\u0103 \u00eenainte \u0219i dup\u0103 testare pentru interpretare integrat\u0103.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Analiz\u0103 genetic\u0103 prenatal\u0103 de \u00eenalt\u0103 rezolu\u021bie, realizat\u0103 prin tehnologia array-CGH (cariotip molecular), destinat\u0103 detect\u0103rii microdele\u021biilor \u0219i microduplica\u021biilor cromozomiale (CNV) la f\u0103t, care nu pot fi de identificate prin cariotipul clasic.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3173,2876],"product_tag":[],"class_list":["post-27659","product","type-product","status-publish","product_cat-analize","product_cat-genetica-in-sarcina","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Analiz\u0103 genetic\u0103 prenatal\u0103 de 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