{"id":27510,"date":"2025-06-24T15:39:55","date_gmt":"2025-06-24T13:39:55","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/hla-b27\/"},"modified":"2026-02-27T18:06:31","modified_gmt":"2026-02-27T16:06:31","slug":"hla-b27","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-diagnostic-genetic\/hla-b27\/","title":{"rendered":"HLA B27"},"content":{"rendered":"<p><strong>HLA-B27<\/strong> este o alel\u0103 a complexului major de histocompatibilitate (MHC clasa I), implicat\u0103 \u00een recunoa\u0219terea antigenelor de c\u0103tre sistemul imun. Prezen\u021ba acestei alele cre\u0219te semnificativ riscul dezvolt\u0103rii unor afec\u021biuni inflamatorii cronice, precum spondilita anchilozant\u0103, artrita reactiv\u0103, artrita psoriazic\u0103 sau artrita asociat\u0103 bolilor inflamatorii intestinale.<\/p>\n<\/p>\n<p>Testul genetic HLA-B27 prin Real-Time PCR ofer\u0103 o metod\u0103 standardizat\u0103, sensibil\u0103 \u0219i reproductibil\u0103 pentru identificarea purt\u0103torilor acestei variante genetice, fiind un instrument esen\u021bial \u00een diagnosticul diferen\u021bial al durerilor lombare inflamatorii \u0219i al spondiloartritelor seronegative.<\/p>\n<\/p>\n<p><strong>Afec\u021biuni sau simptome asociate<\/strong><\/p>\n<\/p>\n<ul>\n<li>spondilita anchilozant\u0103 (Boala Bechterew)<\/li>\n<li>artrita reactiv\u0103 (Sindromul Reiter)<\/li>\n<li>artrita psoriazic\u0103 cu afectare axial\u0103<\/li>\n<li>artrita enteropatic\u0103 (asociat\u0103 bolilor inflamatorii intestinale)<\/li>\n<li>uveit\u0103 anterioar\u0103 recurent\u0103<\/li>\n<li>dureri lombare cronice, rigiditate matinal\u0103, inflama\u021bie articular\u0103<\/li>\n<\/ul>\n<p><strong>Cui se adreseaz\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>persoanelor tinere cu dureri de spate persistente de cauz\u0103 neclar\u0103<\/li>\n<li>pacien\u021bilor cu antecedente de inflama\u021bie ocular\u0103 sau articular\u0103<\/li>\n<li>persoanelor cu istoric familial de spondilit\u0103 anchilozant\u0103 sau alte spondiloartrite<\/li>\n<li>medicilor reumatologi, oftalmologi \u0219i gastroenterologi implica\u021bi \u00een diagnosticul bolilor autoimune inflamatorii<\/li>\n<\/ul>\n<p><strong>Metodologie de testare<\/strong><\/p>\n<\/p>\n<ul>\n<li>metod\u0103: Real-Time PCR (reac\u021bie de polimerizare \u00een lan\u021b \u00een timp real)<\/li>\n<li>principiu: amplificarea \u0219i detec\u021bia fluorescent\u0103 a secven\u021belor specifice genei HLA-B27<\/li>\n<\/ul>\n<p><strong>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>identific\u0103 predispozi\u021bia genetic\u0103 pentru spondiloartrite \u0219i alte boli inflamatorii<\/li>\n<li>ghideaz\u0103 diagnosticul precoce \u0219i managementul personalizat al pacientului<\/li>\n<li>permite excluderea cauzelor genetice la pacien\u021bii cu simptomatologie asem\u0103n\u0103toare<\/li>\n<li>test molecular standardizat, cu acurate\u021be diagnostic\u0103 ridicat\u0103<\/li>\n<\/ul>\n<p><strong>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/strong><\/p>\n<\/p>\n<ul>\n<li>prezen\u021ba HLA-B27 nu confirm\u0103 automat diagnosticul de spondilit\u0103 anchilozant\u0103<\/li>\n<li>lipsa alelei nu exclude complet boala, care poate ap\u0103rea \u0219i la indivizi HLA-B27 negativi<\/li>\n<li>rezultatul trebuie interpretat \u00een context clinic, biologic \u0219i imagistic (ex. RMN articula\u021bii sacroiliace, CRP, VSH)<\/li>\n<\/ul>\n<p><strong>Analize asociate recomandate<\/strong><\/p>\n<\/p>\n<ul>\n<li>markeri inflamatori: CRP, VSH<\/li>\n<li>RMN articula\u021bii sacroiliace<\/li>\n<li>anticorpi autoimuni: ANA, RF, anti-CCP<\/li>\n<li>consult reumatologic<\/li>\n<\/ul>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><strong>Analiza HLA-B27<\/strong> este un test genetic molecular de \u00eenalt\u0103 precizie utilizat pentru identificarea alelei HLA-B27, asociat\u0103 cu predispozi\u021bia la boli autoimune din spectrul spondiloartritelor. Metoda Real-Time PCR permite detectarea rapid\u0103, specific\u0103 \u0219i cantitativ\u0103 a secven\u021bei genetice HLA-B27 din ADN-ul pacientului.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3166,2876],"product_tag":[],"class_list":["post-27510","product","type-product","status-publish","product_cat-analize","product_cat-diagnostic-genetic","product_cat-serviciu-laborator","pa_medical-conditions-spondilita-anchilozanta","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product\/27510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/media?parent=27510"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_brand?post=27510"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_cat?post=27510"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_tag?post=27510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}