{"id":27266,"date":"2025-06-24T14:51:47","date_gmt":"2025-06-24T12:51:47","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8\/"},"modified":"2026-02-27T18:00:08","modified_gmt":"2026-02-27T16:00:08","slug":"predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-diagnostic-genetic\/predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8\/","title":{"rendered":"Predispozitie genetica boala celiaca (HLA DQ2 si DQ8)"},"content":{"rendered":"<p><strong>Boala celiac\u0103<\/strong> este o afec\u021biune autoimun\u0103 cronic\u0103 determinat\u0103 de o reac\u021bie anormal\u0103 la gluten (proteina din gr\u00e2u, orz \u0219i secar\u0103), care duce la atrofie vilozitar\u0103 intestinal\u0103, malabsorb\u021bie \u0219i manifest\u0103ri sistemice.<\/p>\n<\/p>\n<p>Aproximativ 95% dintre pacien\u021bii cu boal\u0103 celiac\u0103 prezint\u0103 HLA-DQ2, iar restul de 5% HLA-DQ8. Cu toate acestea, aceste alele se reg\u0103sesc \u0219i la 25\u201340% din popula\u021bia general\u0103, f\u0103r\u0103 ca to\u021bi purt\u0103torii s\u0103 dezvolte boala.<\/p>\n<\/p>\n<p>Testarea genetic\u0103 ofer\u0103 informa\u021bii despre predispozi\u021bie, nu despre prezen\u021ba activ\u0103 a bolii, dar este esen\u021bial\u0103 \u00een completarea diagnosticului, mai ales \u00een cazurile neconcludente clinic sau serologic.<\/p>\n<\/p>\n<p><strong>Afec\u021biuni sau simptome asociate<\/strong><\/p>\n<\/p>\n<p> Testul este util \u00een contextul clinic al simptomelor \u0219i condi\u021biilor compatibile cu boala celiac\u0103:<\/p>\n<\/p>\n<ul>\n<li>balonare, diaree cronic\u0103, constipa\u021bie persistent\u0103<\/li>\n<li>sc\u0103dere ponderal\u0103, malabsorb\u021bie, deficit de fier sau vitamine<\/li>\n<li>oboseal\u0103 cronic\u0103, anemie feripriv\u0103<\/li>\n<li>osteoporoz\u0103 precoce<\/li>\n<li>infertilitate de cauz\u0103 necunoscut\u0103<\/li>\n<li>dermatit\u0103 herpetiform\u0103<\/li>\n<li>tulbur\u0103ri autoimune asociate (diabet zaharat tip 1, tiroidit\u0103 autoimun\u0103, hepatit\u0103 autoimun\u0103)<\/li>\n<\/ul>\n<p><strong>Cui se adreseaz\u0103 analiza<\/strong><\/p>\n<\/p>\n<ul>\n<li>persoanelor cu simptome sugestive de boal\u0103 celiac\u0103, dar cu rezultate serologice neconcludente (anticorpi anti-transglutaminaz\u0103 sau anti-endomisium negativi)<\/li>\n<li>pacien\u021bilor cu rude de gradul I diagnosticate cu boal\u0103 celiac\u0103<\/li>\n<li>copiilor sau adul\u021bilor cu alte boli autoimune (diabet tip 1, tiroidit\u0103 autoimun\u0103, boal\u0103 Addison etc.)<\/li>\n<li>pacien\u021bilor cu intoleran\u021b\u0103 la gluten f\u0103r\u0103 confirmare histologic\u0103<\/li>\n<li>\u00een diagnosticul diferen\u021bial al sindroamelor de malabsorb\u021bie<\/li>\n<\/ul>\n<p><strong>Metodologie de testare<\/strong><\/p>\n<\/p>\n<p>Determinarea se realizeaz\u0103 prin analiza ADN genomic extras din leucocite, urmat\u0103 de amplificare \u0219i detectare prin Real-Time PCR (tehnologie de biologie molecular\u0103) pentru identificarea alelelor specifice HLA-DQA1 \u0219i HLA-DQB1 asociate cu DQ2 \u0219i DQ8.<\/p>\n<\/p>\n<p><strong>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>excluderea bolii celiace: absen\u021ba haplotipurilor HLA-DQ2 \u0219i HLA-DQ8 exclude practic diagnosticul (valoare predictiv\u0103 negativ\u0103 &gt;99%)<\/li>\n<li>suport \u00een diagnosticul diferen\u021bial pentru cazurile seronegative sau neconcludente<\/li>\n<li>identificarea persoanelor cu predispozi\u021bie genetic\u0103 la dezvoltarea bolii<\/li>\n<li>informa\u021bie util\u0103 pentru rudele pacien\u021bilor diagnostica\u021bi, \u00een scop preventiv sau de monitorizare<\/li>\n<li>complementaritate cu testele serologice \u0219i histologice pentru o evaluare complet\u0103<\/li>\n<\/ul>\n<p><strong>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/strong><\/p>\n<\/p>\n<ul>\n<li>prezen\u021ba haplotipurilor HLA-DQ2 sau DQ8 nu confirm\u0103 diagnosticul de boal\u0103 celiac\u0103 \u2013 doar predispozi\u021bia<\/li>\n<li>testul nu evalueaz\u0103 nivelul anticorpilor specifici glutenului \u0219i nu indic\u0103 activitatea bolii<\/li>\n<li>\u00een absen\u021ba markerilor HLA-DQ2\/DQ8, diagnosticul de boal\u0103 celiac\u0103 este practic exclus<\/li>\n<\/ul>\n<p><strong>Tip prob\u0103 \u0219i condi\u021bii pentru recoltare<\/strong><\/p>\n<\/p>\n<ul>\n<li>prob\u0103: s\u00e2nge integral (EDTA)<\/li>\n<li>volum necesar: <strong>2 \u00d7 6 ml<\/strong><\/li>\n<li>condi\u021bii: p\u0103strare la <strong>2\u20138 \u00b0C<\/strong> p\u00e2n\u0103 la transport; se evit\u0103 congelarea<\/li>\n<li>recoltare: nu necesit\u0103 condi\u021bii speciale (nu este necesar s\u0103 fie pe nem\u00e2ncate)<\/li>\n<\/ul>\n<p><strong>Analize asociate recomandate<\/strong><\/p>\n<\/p>\n<p> Pentru o evaluare complet\u0103 a bolii celiace se recomand\u0103:<\/p>\n<\/p>\n<ul>\n<li>anticorpi anti-transglutaminaz\u0103 tisular\u0103 (IgA \u0219i IgG)<\/li>\n<li>anticorpi anti-endomisium (IgA)<\/li>\n<li>IgA total seric (pentru excluderea deficitului de IgA)<\/li>\n<li>biopsie duodenal\u0103 (pentru confirmarea histologic\u0103 a diagnosticului)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Testul genetic pentru predispozi\u021bia la boala celiac\u0103 (intoleran\u021ba la gluten) determin\u0103 prezen\u021ba haplotipurilor HLA-DQ2 \u0219i HLA-DQ8, asociate cu un risc crescut de dezvoltare a acestei afec\u021biuni autoimune declan\u0219ate de ingestia glutenului. Prezen\u021ba acestor haplotipuri nu confirm\u0103 boala, dar excluderea lor are o valoare predictiv\u0103 negativ\u0103 foarte mare (&gt;99%), indic\u00e2nd un risc extrem de sc\u0103zut de a dezvolta boala celiac\u0103 pe parcursul vie\u021bii.<\/p>\n<\/p>\n<p><strong>Gene analizate<\/strong><\/p>\n<\/p>\n<p>Testul analizeaz\u0103 alelele implicate \u00een formarea complexelor HLA asociate cu boala celiac\u0103, HLA-DQA1 \u0219i HLA-DQB1 \u2013 pentru identificarea haplotipurilor:<\/p>\n<\/p>\n<ul>\n<li>HLA-DQ2.5 (DQA105:01 \/ DQB102:01)<\/li>\n<li>HLA-DQ2.2 (DQA102:01 \/ DQB102:02)<\/li>\n<li>HLA-DQ8 (DQA103:01 \/ DQB103:02)<\/li>\n<\/ul>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3166,2876],"product_tag":[],"class_list":["post-27266","product","type-product","status-publish","product_cat-analize","product_cat-diagnostic-genetic","product_cat-serviciu-laborator","pa_medical-conditions-boala-celiaca","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Testul genetic pentru predispozi\u021bia la boala celiac\u0103 (intoleran\u021ba la gluten) determin\u0103 prezen\u021ba haplotipurilor HLA-DQ2 \u0219i HLA-DQ8, asociate cu un risc crescut de dezvoltare a acestei afec\u021biuni autoimune declan\u0219ate de ingestia glutenului. Prezen\u021ba acestor haplotipuri nu confirm\u0103 boala, dar excluderea lor are o valoare predictiv\u0103 negativ\u0103 foarte mare (&gt;99%), indic\u00e2nd un risc extrem de sc\u0103zut de a dezvolta boala celiac\u0103 pe parcursul vie\u021bii.Gene analizateTestul analizeaz\u0103 alelele implicate \u00een formarea complexelor HLA asociate cu boala celiac\u0103, HLA-DQA1 \u0219i HLA-DQB1 \u2013 pentru identificarea haplotipurilor:HLA-DQ2.5 (DQA105:01 \/ DQB102:01)HLA-DQ2.2 (DQA102:01 \/ DQB102:02)HLA-DQ8 (DQA103:01 \/ DQB103:02)\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.clinica-sante.com\/ro\/analize-diagnostic-genetic\/predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinica Sante - Laborator de Analize Medicale - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Predispozitie genetica boala celiaca (HLA DQ2 si DQ8) - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:description\" content=\"Testul genetic pentru predispozi\u021bia la boala celiac\u0103 (intoleran\u021ba la gluten) determin\u0103 prezen\u021ba haplotipurilor HLA-DQ2 \u0219i HLA-DQ8, asociate cu un risc crescut de dezvoltare a acestei afec\u021biuni autoimune declan\u0219ate de ingestia glutenului. Prezen\u021ba acestor haplotipuri nu confirm\u0103 boala, dar excluderea lor are o valoare predictiv\u0103 negativ\u0103 foarte mare (&gt;99%), indic\u00e2nd un risc extrem de sc\u0103zut de a dezvolta boala celiac\u0103 pe parcursul vie\u021bii.Gene analizateTestul analizeaz\u0103 alelele implicate \u00een formarea complexelor HLA asociate cu boala celiac\u0103, HLA-DQA1 \u0219i HLA-DQB1 \u2013 pentru identificarea haplotipurilor:HLA-DQ2.5 (DQA105:01 \/ DQB102:01)HLA-DQ2.2 (DQA102:01 \/ DQB102:02)HLA-DQ8 (DQA103:01 \/ DQB103:02)\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.clinica-sante.com\/ro\/analize-diagnostic-genetic\/predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8\/\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2025-06-24T12:51:47+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-02-27T16:00:08+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Predispozitie genetica boala celiaca (HLA DQ2 si DQ8) - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Testul genetic pentru predispozi\u021bia la boala celiac\u0103 (intoleran\u021ba la gluten) determin\u0103 prezen\u021ba haplotipurilor HLA-DQ2 \u0219i HLA-DQ8, asociate cu un risc crescut de dezvoltare a acestei afec\u021biuni autoimune declan\u0219ate de ingestia glutenului. Prezen\u021ba acestor haplotipuri nu confirm\u0103 boala, dar excluderea lor are o valoare predictiv\u0103 negativ\u0103 foarte mare (&gt;99%), indic\u00e2nd un risc extrem de sc\u0103zut de a dezvolta boala celiac\u0103 pe parcursul vie\u021bii.Gene analizateTestul analizeaz\u0103 alelele implicate \u00een formarea complexelor HLA asociate cu boala celiac\u0103, HLA-DQA1 \u0219i HLA-DQB1 \u2013 pentru identificarea haplotipurilor:HLA-DQ2.5 (DQA105:01 \/ DQB102:01)HLA-DQ2.2 (DQA102:01 \/ DQB102:02)HLA-DQ8 (DQA103:01 \/ DQB103:02)\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-diagnostic-genetic\\\/predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro#listItem\",\"position\":1,\"name\":\"Prima pagin\\u0103\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"name\":\"Analize Medicale\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"position\":2,\"name\":\"Analize Medicale\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"name\":\"Analize\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro#listItem\",\"name\":\"Prima pagin\\u0103\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"position\":3,\"name\":\"Analize\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"name\":\"Serviciu laborator\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"name\":\"Analize Medicale\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"position\":4,\"name\":\"Serviciu laborator\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-diagnostic-genetic\\\/#listItem\",\"name\":\"Diagnostic genetic\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"name\":\"Analize\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-diagnostic-genetic\\\/#listItem\",\"position\":5,\"name\":\"Diagnostic genetic\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-diagnostic-genetic\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-diagnostic-genetic\\\/predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8\\\/#listItem\",\"name\":\"Predispozitie genetica boala celiaca (HLA DQ2 si DQ8)\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"name\":\"Serviciu laborator\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-diagnostic-genetic\\\/predispozitie-genetica-boala-celiaca-hla-dq2-si-dq8\\\/#listItem\",\"position\":6,\"name\":\"Predispozitie genetica boala celiaca (HLA DQ2 si DQ8)\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-diagnostic-genetic\\\/#listItem\",\"name\":\"Diagnostic genetic\"}}]},{\"@type\":\"MedicalOrganization\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/#organization\",\"name\":\"Clinica Sante - 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