{"id":27170,"date":"2025-06-24T15:46:11","date_gmt":"2025-06-24T12:46:11","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/leucemia-mieloida-acuta-lma-panel-genetic-ngs-mysla\/"},"modified":"2026-06-30T17:22:25","modified_gmt":"2026-06-30T14:22:25","slug":"leucemia-mieloida-acuta-lma-panel-genetic-ngs-mysla","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/leucemia-mieloida-acuta-lma-panel-genetic-ngs-mysla\/","title":{"rendered":"Leucemia mieloida acuta (LMA) &#8211; panel genetic NGS [MYSLA]"},"content":{"rendered":"<p>Leucemia mieloid\u0103 acut\u0103 (LMA) este o neoplazie hematologic\u0103 agresiv\u0103 caracterizat\u0103 prin proliferarea clonal\u0103 a precursorilor mieloizi imaturi \u00een m\u0103duva osoas\u0103, s\u00e2nge periferic \u0219i alte \u021besuturi.<\/p>\n<p>Panelul MYSLA analizeaz\u0103 un set extins de gene implicate \u00een patogeneza LMA, incluz\u00e2nd muta\u021bii cu valoare diagnostic\u0103, prognostic\u0103 \u0219i terapeutic\u0103. Aceste alter\u0103ri genetice influen\u021beaz\u0103 comportamentul bolii, r\u0103spunsul la tratament \u0219i riscul de rec\u0103dere.<\/p>\n<p>Prin utilizarea tehnologiei NGS, testul permite identificarea variantelor somatice punctiforme, inser\u021biilor\/dele\u021biilor mici \u0219i altor modific\u0103ri genetice relevante clinic, contribuind la o clasificare molecular\u0103 modern\u0103 a LMA conform ghidurilor interna\u021bionale.<\/p>\n<h3>Afec\u021biuni sau simptome asociate:<\/h3>\n<ul>\n<li>Leucemie mieloid\u0103 acut\u0103 (toate subtipurile);<\/li>\n<li>Pancitopenie (anemie, trombocitopenie, neutropenie);<\/li>\n<li>Infec\u021bii recurente sau severe;<\/li>\n<li>S\u00e2nger\u0103ri spontane sau prelungite;<\/li>\n<li>Fatigabilitate sever\u0103, dispnee;<\/li>\n<li>Febr\u0103 f\u0103r\u0103 cauz\u0103 infec\u021bioas\u0103 evident\u0103;<\/li>\n<li>Infiltra\u021bie medular\u0103 cu blasti.<\/li>\n<\/ul>\n<h3>Cui se adreseaz\u0103:<\/h3>\n<p><strong>Medicilor hematologi, oncologilor, anatomopatologilor<\/strong> \u0219i speciali\u0219tilor implica\u021bi \u00een diagnosticul, monitorizarea \u0219i tratamentul pacien\u021bilor cu suspiciune sau diagnostic confirmat de leucemie mieloid\u0103 acut\u0103.<\/p>\n<h3>Metodologie de testare:<\/h3>\n<p>Analiza este realizat\u0103 prin secven\u021biere de nou\u0103 genera\u021bie (NGS) a ADN-ului extras din probe de s\u00e2nge periferic sau m\u0103duv\u0103 osoas\u0103 (\u00een func\u021bie de contextul clinic).<\/p>\n<h3>Panelul MYSLA include gene frecvent implicate \u00een LMA, relevante pentru:<\/h3>\n<ul>\n<li>diagnostic molecular;<\/li>\n<li>clasificare prognostic\u0103;<\/li>\n<li>identificarea muta\u021biilor ac\u021bionabile terapeutic.<\/li>\n<\/ul>\n<p>Sunt detectate variante somatice punctiforme, inser\u021bii\/dele\u021bii mici \u0219i muta\u021bii cu semnifica\u021bie clinic\u0103 cunoscut\u0103 sau poten\u021bial relevant\u0103.<\/p>\n<h3>Beneficii \u0219i importan\u021b\u0103 clinic\u0103:<\/h3>\n<ul>\n<li>Contribuie la confirmarea diagnosticului molecular de LMA;<\/li>\n<li>Permite stratificarea riscului (favorabil\/intermediar\/nefavorabil);<\/li>\n<li>Ghideaz\u0103 alegerea terapiei \u021bintite;<\/li>\n<li>Ofer\u0103 informa\u021bii prognostice esen\u021biale;<\/li>\n<li>Sus\u021bine monitorizarea bolii minime reziduale (\u00een corelare cu alte teste);<\/li>\n<li>Ajut\u0103 la personalizarea planului terapeutic.<\/li>\n<\/ul>\n<h3>Particularit\u0103\u021bi \u0219i limit\u0103ri:<\/h3>\n<ul>\n<li>Nu detecteaz\u0103 modific\u0103ri cromozomiale mari (necesit\u0103 cariotipare\/FISH);<\/li>\n<li>Sensibilitatea depinde de procentul de blasti din prob\u0103;<\/li>\n<li>Nu \u00eenlocuie\u0219te analiza morfologic\u0103 \u0219i imunofenotiparea;<\/li>\n<li>Unele variante pot necesita validare suplimentar\u0103 (Sanger sau metode alternative);<\/li>\n<li>Interpretarea trebuie realizat\u0103 strict \u00een context hematologic complet.<\/li>\n<\/ul>\n<h3>Tip prob\u0103:<\/h3>\n<p>S\u00e2nge periferic, 2 \u00d7 6 ml (EDTA)<\/p>\n<h3>Recoltare:<\/h3>\n<p>Proba se recolteaz\u0103 \u00een vacutainer cu EDTA.<\/p>\n<h3>Condi\u021bii:<\/h3>\n<p>Transport la 2\u20138\u00b0C.<\/p>\n<h3>Denumiri alternative:<\/h3>\n<p>Panel NGS LMA; Profil genetic leucemie mieloid\u0103 acut\u0103; Test muta\u021bional LMA; Analiz\u0103 genomic\u0103 MYSLA; Secven\u021biere somatic\u0103 LMA.<\/p>\n<h3>Analize asociate recomandate:<\/h3>\n<ul>\n<li>Imunofenotipare prin citometrie \u00een flux;<\/li>\n<li>Cariotipare medular\u0103;<\/li>\n<li>FISH pentru anomalii recurente \u00een LMA;<\/li>\n<li>Monitorizare MRD (boal\u0103 minim\u0103 rezidual\u0103);<\/li>\n<li>Biopsie de m\u0103duv\u0103 osoas\u0103;<\/li>\n<li>Teste hematologice complete (hemogram\u0103, coagulare).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Panel genetic complex, realizat prin secven\u021biere de nou\u0103 genera\u021bie (NGS), pentru detectarea muta\u021biilor somatice relevante \u00een leucemia mieloid\u0103 acut\u0103 (LMA), utilizat pentru stratificarea riscului, confirmarea diagnosticului molecular \u0219i ghidarea deciziilor terapeutice personalizate.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3165,2876],"product_tag":[],"class_list":["post-27170","product","type-product","status-publish","product_cat-analize","product_cat-oncogenetica","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Panel genetic complex, realizat prin secven\u021biere de nou\u0103 genera\u021bie (NGS), pentru detectarea muta\u021biilor somatice relevante \u00een leucemia mieloid\u0103 acut\u0103 (LMA), utilizat pentru stratificarea riscului, confirmarea diagnosticului 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