{"id":27163,"date":"2025-06-24T14:45:47","date_gmt":"2025-06-24T12:45:47","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/panel-genetic-diabet-si-obezitate-diabetes-and-obesity-panel\/"},"modified":"2026-02-27T17:58:33","modified_gmt":"2026-02-27T15:58:33","slug":"panel-genetic-diabet-si-obezitate-diabetes-and-obesity-panel","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-diagnostic-genetic\/panel-genetic-diabet-si-obezitate-diabetes-and-obesity-panel\/","title":{"rendered":"Panel genetic Diabet si obezitate &#8211; Diabetes and obesity panel"},"content":{"rendered":"<p>Diabetul zaharat \u0219i obezitatea reprezint\u0103 dou\u0103 fenomene adesea interdependente, av\u00e2nd etiologie multifactorial\u0103 \u2014 incluz\u00e2nd factori genetici, mediu \u0219i stil de via\u021b\u0103. Panelul genetic oferit de Centogene folose\u0219te tehnologie de secven\u021biere de tip NGS cu acoperire ampl\u0103 (inclusiv analiz\u0103 a CNV-urilor) pentru a eviden\u021bia at\u00e2t formele monogenice rare, c\u00e2t \u0219i variantele de susceptibilitate poligenic\u0103.<\/p>\n<\/p>\n<p>Rezultatul ofer\u0103 o interpretare clinic\u0103 care poate fi utilizat\u0103 \u00een consilierea genetic\u0103, elaborarea strategiei preventive \u0219i personalizarea monitoriz\u0103rii \u0219i tratamentului.<\/p>\n<\/p>\n<p><strong>Afec\u021biuni sau simptome asociate<\/strong><\/p>\n<\/p>\n<ul>\n<li>diabet zaharat de tip 1, tip 2 sau forme monogenice (ex. MODY)<\/li>\n<li>obezitate sever\u0103, \u00een special la v\u00e2rst\u0103 t\u00e2n\u0103r\u0103<\/li>\n<li>tulbur\u0103ri de toleran\u021b\u0103 la glucoz\u0103, insulinorezisten\u021b\u0103<\/li>\n<li>hipertrigliceridemie, steatoz\u0103 hepatic\u0103 non-alcoolic\u0103, sindrom metabolic<\/li>\n<li>istoric familial puternic de diabet sau obezitate, r\u0103spuns slab la interven\u021bii de stil de via\u021b\u0103<\/li>\n<\/ul>\n<p><strong>Cui se adreseaz\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>persoanelor cu obezitate sever\u0103 (BMI mare), mai ales cu debut precoce (&lt; 30 ani) sau cu istoric familial relevant<\/li>\n<li>pacien\u021bilor cu diabet zaharat la v\u00e2rst\u0103 t\u00e2n\u0103r\u0103 sau forme atipice f\u0103r\u0103 cauz\u0103 clar\u0103<\/li>\n<li>pacien\u021bilor cu familie numeroas\u0103 afectat\u0103 de diabet\/obezitate care solicit\u0103 evaluare genetic\u0103 de risc<\/li>\n<li>medicilor endocrinologi, diabetologi, geneticieni care doresc o perspectiv\u0103 genetic\u0103 \u00een managementul acestor afec\u021biuni<\/li>\n<\/ul>\n<p><strong>Metodologie de testare<\/strong><\/p>\n<\/p>\n<ul>\n<li>secven\u021biere NGS de mare performan\u021b\u0103 pe panelul de 265 de gene (inclusiv acoperire \u2265 99% sub 20\u00d7)<\/li>\n<li>analiz\u0103 de tip SNV, INDEL, CNV, cu interpretare bioinformatic\u0103<\/li>\n<li>raport clinic detaliat care include recomand\u0103ri privind consilierea genetic\u0103, managementul \u0219i monitorizarea pe termen lung<\/li>\n<\/ul>\n<p><strong>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>identific\u0103 predispozi\u021bii genetice care pot influen\u021ba alegerea interven\u021biilor preventive (nutri\u021bie, stil de via\u021b\u0103)<\/li>\n<li>opereaz\u0103 \u00eentr-o manier\u0103 personalizat\u0103, contribuind la optimizarea strategiei terapeutice (ex. intensificarea monitoriz\u0103rii sau ini\u021bierea timpurie a tratamentului)<\/li>\n<li>poate ajuta la diferen\u021bierea unei forme genetice rare de obezitate sau diabet de formele comune multifactoriale<\/li>\n<li>ofer\u0103 informa\u021bii utile pentru consilierea familial\u0103 \u0219i screeningul rudelor<\/li>\n<\/ul>\n<p><strong>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/strong><\/p>\n<\/p>\n<ul>\n<li>un rezultat negativ nu exclude complet o cauz\u0103 genetic\u0103 \u2014 exist\u0103 gene sau mecanisme \u00eenc\u0103 necunoscute<\/li>\n<li>variantele de semnifica\u021bie incert\u0103 (VUS) pot necesita urm\u0103rire, reevaluare sau studii familiale<\/li>\n<li>panelul acoper\u0103 gene definite \u0219i varianta lor codant\u0103\/regulatorie, dar nu toate variantele posibile (ex. epigenetic\u0103, modific\u0103ri post-transcrip\u021bionale)<\/li>\n<li>interpretarea rezultatelor trebuie f\u0103cut\u0103 \u00een context clinic integrat (factori de mediu, stil de via\u021b\u0103, comorbidit\u0103\u021bi)<\/li>\n<\/ul>\n<p><strong>Analize asociate recomandate<\/strong><\/p>\n<\/p>\n<ul>\n<li>evaluare endocrinologic\u0103 complet\u0103: glicemie, HbA1c, insulin\u0103, C-peptid\u0103, profil lipidic<\/li>\n<li>evaluarea complica\u021biilor metabolice: steatoz\u0103 hepatic\u0103, func\u021bie renal\u0103, tensiune arterial\u0103<\/li>\n<li>evaluare stil de via\u021b\u0103 \u0219i interven\u021bii privind nutri\u021bia, activitatea fizic\u0103<\/li>\n<li>consiliere genetic\u0103 familial\u0103 \u00een cazul identific\u0103rii unei variante patologice<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p><strong>Panel Genetic Diabet \u0219i Obezitate \u2013 <em>Diabetes and Obesity Panel<\/em> <\/strong>este o analiz\u0103 genetic\u0103 cuprinz\u0103toare care investigheaz\u0103 265 de gene asociate predispozi\u021biei la diabet zaharat, obezitate, tulbur\u0103ri de metabolism al glucozei \u0219i adipositate corporal\u0103.<\/p>\n<\/p>\n<p> Testul are ca scop identificarea componentelor genetice care pot contribui la apari\u021bia precoce a diabetului, la formele monogenice de obezitate sau la susceptibilitatea extins\u0103 la aceste afec\u021biuni.<\/p>\n<\/p>\n<p><strong>Gene analizate<\/strong><\/p>\n<\/p>\n<p>Incluse \u00een panel sunt aproximativ 265 de gene relevante pentru diabet \u0219i obezitate (codificare genic\u0103, variante de risc, regiuni de reglare)<strong>.<\/strong><\/p>\n<\/p>\n<p><strong>Not\u0103:<\/strong> Lista complet\u0103 a genelor:<\/p>\n<p> ABCA1, ABCC8, ABCG5, ABCG8, ACAT1, ACSF3, ADCY3, AFF4, AGL, AGRP, AIP, AIRE, AKT2, ALDOA, ALDOB, ALG1, ALG11, ALG12, ALG3, ALG6, ALG8, ALG9, ANGPTL3, APOA1, APOA5, APOB, APOC2, APOC3, APOE, APPL1, AQP2, ARL13B, ARL6, ARMC5, ATP6V0A2, AVP, AVPR2, B4GALT1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BDNF, BLK, CANT1, CC2D2A, CCDC28B, CEL, CEP164, CEP19, CEP290, CETP, CFAP418, CHD2, CISD2, CNOT1, COG1, COG4, COG5, COG6, COG7, COG8, CP, CPE, CREBBP, CUL4B, CYP27A1, DCAF17, DNAJC3, DOLK, DPM1, DPM2, DPM3, DYRK1B, EHMT1, EIF2AK3, EIF2B1, EIF2S3, ENO3, ENPP1, EPM2A, FBP1, FOXP3, G6PC1, GAA, GATA6, GBE1, GCK, GCKR, GH1, GHR, GHRHR, GHRL, GLI3, GLIS3, GLUD1, GMPPA, GNAS, GNE, GPC3, GPD1, GPIHBP1, GYS1, GYS2, H6PD, HADH, HEXA, HMGCL, HMGCS2, HNF1A, HNF1B, HNF4A, HSD11B1, IER3IP1, IFT172, IFT27, IGF1R, INPP5E, INS, INSR, ITCH, KCNJ11, KIDINS220, KIF7, KLF11, KMT2C, KSR2, LAMP2, LARGE1, LAS1L, LDHA, LDLR, LDLRAP1, LEP, LEPR, LIPA, LIPC, LIPE, LMF1, LMNA, LPL, LZTFL1, MAGEL2, MAN1B1, MC3R, MC4R, MCHR1, MEGF8, MGAT2, MKKS, MKRN3, MKS1, MOGS, MPDU1, MPI, MPV17, MRAP2, MTNR1B, MTTP, MYO5A, MYO7A, MYT1L, NDN, NEUROD1, NEUROG3, NGLY1, NHLRC1, NKX2-2, NPHP1, NPHP3, NR0B2, NSD1, NTRK2, OFD1, OXCT1, PAX4, PAX6, PC, PCBD1, PCK1, PCNT, PCSK1, PCSK9, PDE11A, PDE4D, PDX1, PFKM, PGAM2, PGK1, PGM1, PHF6, PHIP, PHKA1, PHKA2, PHKB, PHKG2, PIK3R1, PMM2, PNPLA6, POLD1, POMC, PPARG, PPP1R15B, PRKAG2, PRKAR1A, PRMT7, PROM1, PRPH2, PTEN, PTF1A, PYGL, PYGM, RAB23, RAI1, RBCK1, RDH5, RFT1, RFX6, RHO, RLBP1, RPGRIP1L, RPS6KA3, SDCCAG8, SETD2, SH2B1, SIM1, SLC16A1, SLC19A2, SLC29A3, SLC2A2, SLC35A1, SLC35A2, SLC35C1, SNRPN, SPG11, SRD5A3, SSR4, STAT1, STAT3, TBX3, THOC2, THRA, TMEM165, TMEM67, TRAF3IP1, TRAPPC9, TRIM32, TRMT10A, TTC21B, TTC8, TUSC3, UCP2, UCP3, VPS13B, WFS1, XRCC4, XYLT1, ZBTB20, ZFP57, ZMPSTE24, ZNF711<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3166,2876],"product_tag":[],"class_list":["post-27163","product","type-product","status-publish","product_cat-analize","product_cat-diagnostic-genetic","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product\/27163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/media?parent=27163"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_brand?post=27163"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_cat?post=27163"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_tag?post=27163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}