{"id":27084,"date":"2025-06-24T15:41:22","date_gmt":"2025-06-24T12:41:22","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/panel-genetic-somatic-cancer-san-din-biopsie-lichida-12-gene\/"},"modified":"2026-06-19T18:27:04","modified_gmt":"2026-06-19T15:27:04","slug":"panel-genetic-somatic-cancer-san-din-biopsie-lichida-12-gene","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/panel-genetic-somatic-cancer-san-din-biopsie-lichida-12-gene\/","title":{"rendered":"Panel genetic somatic cancer san din biopsie lichida"},"content":{"rendered":"<p>Biopsia lichid\u0103 reprezint\u0103 o metod\u0103 modern\u0103, minim invaziv\u0103, de caracterizare molecular\u0103 a tumorilor prin analiza ADN-ului tumoral circulant (ctDNA) eliberat \u00een s\u00e2nge de celulele canceroase.<\/p>\n<p>Panelul somatic pentru cancer de s\u00e2n realizat de Bioarray utilizeaz\u0103 tehnologia <strong>NGS (Next Generation Sequencing)<\/strong> pentru analiza genelor relevante clinic \u00een cancerul mamar. Testul permite identificarea muta\u021biilor somatice asociate cu sensibilitatea sau rezisten\u021ba la terapiile oncologice moderne \u0219i poate oferi informa\u021bii complementare biopsiei tisulare, \u00een special atunci c\u00e2nd recoltarea \u021besutului tumoral este dificil\u0103 sau insuficient\u0103.<\/p>\n<p>Conform informa\u021biilor disponibile de la Bioarray, panelul analizeaz\u0103 12 gene cu relevan\u021b\u0103 clinic\u0103 \u00een cancerul de s\u00e2n, incluz\u00e2nd gene implicate \u00een r\u0103spunsul la terapii anti-HER2, terapii endocrine \u0219i alte terapii \u021bintite.<\/p>\n<h3>Indica\u021bii de testare<\/h3>\n<ul>\n<li>Cancer de s\u00e2n diagnosticat histopatologic<\/li>\n<li>Cancer de s\u00e2n metastatic sau avansat local<\/li>\n<li>Selec\u021bia terapiei personalizate \u0219i a terapiilor \u021bintite<\/li>\n<li>Monitorizarea r\u0103spunsului la tratament<\/li>\n<li>Detectarea mecanismelor de rezisten\u021b\u0103 la tratamentul endocrin<\/li>\n<li>Monitorizarea progresiei bolii<\/li>\n<li>Evaluarea heterogenit\u0103\u021bii tumorale<\/li>\n<li>Situa\u021bii \u00een care biopsia tumoral\u0103 nu este posibil\u0103 sau este insuficient\u0103<\/li>\n<li>Monitorizarea recuren\u021bei bolii \u00een context clinic selectat<\/li>\n<\/ul>\n<h3>Cui se adreseaz\u0103<\/h3>\n<ul>\n<li>Pacien\u021bilor cu cancer de s\u00e2n confirmat histologic<\/li>\n<li>Pacien\u021bilor cu boal\u0103 metastatic\u0103<\/li>\n<li>Pacien\u021bilor afla\u021bi sub tratament oncologic sistemic<\/li>\n<li>Pacien\u021bilor eligibili pentru terapii \u021bintite<\/li>\n<li>Medicilor oncologi implica\u021bi \u00een managementul cancerului mamar<\/li>\n<li>Pacien\u021bilor pentru care este necesar\u0103 monitorizarea molecular\u0103 a bolii<\/li>\n<\/ul>\n<h3>Metodologie de testare<\/h3>\n<ul>\n<li>Biopsie lichid\u0103 din s\u00e2nge periferic<\/li>\n<li>Izolarea ADN-ului tumoral circulant (ctDNA) din plasm\u0103<\/li>\n<li>Secven\u021biere de nou\u0103 genera\u021bie (<strong>NGS<\/strong>)<\/li>\n<li>Detectarea muta\u021biilor somatice relevante clinic<\/li>\n<li>Identificarea anumitor varia\u021bii ale num\u0103rului de copii (CNV) pentru gene specifice<\/li>\n<li>Analiz\u0103 bioinformatic\u0103 \u0219i interpretare clinic\u0103 specializat\u0103<\/li>\n<\/ul>\n<h3>Panelul de testare include gene precum:<\/h3>\n<h3>PIK3CA,\u00a0ESR1,\u00a0ERBB2, (HER2), AKT1,\u00a0TP53,\u00a0KRAS,\u00a0EGFR,\u00a0ERBB3,\u00a0FGFR1,\u00a0CCND1,\u00a0BXW7,\u00a0SF3B1.<\/h3>\n<h3>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/h3>\n<ul>\n<li>Metod\u0103 minim invaziv\u0103 comparativ cu biopsia tumoral\u0103 clasic\u0103<\/li>\n<li>Permite caracterizarea molecular\u0103 a tumorii dintr-o simpl\u0103 prob\u0103 de s\u00e2nge<\/li>\n<li>Identific\u0103 muta\u021bii ac\u021bionabile terapeutic<\/li>\n<li>Contribuie la alegerea tratamentului personalizat<\/li>\n<li>Eviden\u021biaz\u0103 mecanisme de rezisten\u021b\u0103 la terapii endocrine \u0219i \u021bintite<\/li>\n<li>Permite monitorizarea dinamic\u0103 a bolii<\/li>\n<li>Poate detecta modific\u0103ri moleculare \u00eenaintea progresiei eviden\u021biate imagistic<\/li>\n<li>Ofer\u0103 informa\u021bii despre heterogenitatea tumoral\u0103 \u0219i clonele rezistente la tratament<\/li>\n<\/ul>\n<h3>Analize asociate recomandate:<\/h3>\n<h3>Investiga\u021bii anatomopatologice \u0219i moleculare<\/h3>\n<ul>\n<li>Examen histopatologic \u0219i imunohistochimic tumoral<\/li>\n<li>ER (receptor estrogenic)<\/li>\n<li>PR (receptor progesteronic)<\/li>\n<li>HER2\/neu<\/li>\n<li>Ki-67<\/li>\n<li>Testare BRCA1 \u0219i BRCA2 (germinal\u0103 \u0219i\/sau somatic\u0103)<\/li>\n<li>Panel extins de gene implicate \u00een repararea ADN-ului (HRD)<\/li>\n<\/ul>\n<h3>Monitorizare oncologic\u0103<\/h3>\n<ul>\n<li>Markeri tumorali (CA 15-3, CEA)<\/li>\n<li>PET-CT \/ CT \/ RMN conform indica\u021biei oncologului<\/li>\n<li>Biopsie tisular\u0103 tumoral\u0103 atunci c\u00e2nd este disponibil\u0103<\/li>\n<\/ul>\n<h3>Teste genetice complementare<\/h3>\n<ul>\n<li>Panel somatic extins pentru tumori solide<\/li>\n<li>Cancer Comprehensive NGS Panel<\/li>\n<li>Testare germinal\u0103 pentru predispozi\u021bie ereditar\u0103 la cancer mamar \u0219i ovarian<\/li>\n<\/ul>\n<h3>Prob\u0103 recoltat\u0103 \/ condi\u021bii analiz\u0103<\/h3>\n<h3>S\u00e2nge venos periferic<\/h3>\n<h3>Tub Streck (Cell-Free DNA Collection Tube)<\/h3>\n<ul>\n<li>Recoltare conform protocolului pentru biopsie lichid\u0103<\/li>\n<li>Proba trebuie transportat\u0103 \u00een condi\u021biile recomandate pentru conservarea ADN-ului tumoral liber circulant<\/li>\n<li>Nu necesit\u0103 condi\u021bii speciale de preg\u0103tire<\/li>\n<\/ul>\n<h3>Obligatoriu: transmiterea documentelor medicale relevante care confirm\u0103 diagnosticul oncologic \u0219i furnizeaz\u0103 informa\u021biile clinice necesare interpret\u0103rii rezultatelor<\/h3>\n<h3>Denumiri alternative<\/h3>\n<ul>\n<li>Breast Cancer Liquid Biopsy<\/li>\n<li>Panel somatic cancer mamar din biopsie lichid\u0103<\/li>\n<li>Breast cfDNA Assay<\/li>\n<li>Breast Cancer ctDNA Panel<\/li>\n<li>Test genetic somatic cancer de s\u00e2n<\/li>\n<li>NGS Breast Liquid Biopsy<\/li>\n<li>Analiz\u0103 molecular\u0103 din biopsie lichid\u0103 pentru cancer mamar<\/li>\n<li>Panel muta\u021bii somatice cancer de s\u00e2n<\/li>\n<li>ctDNA Breast Cancer Testing<\/li>\n<li>Liquid Biopsy Breast Cancer Panel<\/li>\n<\/ul>\n<h3>Particularit\u0103\u021bi ale testului<\/h3>\n<p>Acest test analizeaz\u0103 modific\u0103ri genetice <strong>somatice<\/strong> (dob\u00e2ndite la nivel tumoral) \u0219i nu este destinat identific\u0103rii predispozi\u021biei ereditare la cancer. Pentru evaluarea riscului genetic familial se recomand\u0103 asocierea cu testarea germinal\u0103 pentru genele implicate \u00een cancerul mamar ereditar (BRCA1, BRCA2 \u0219i alte gene relevante). Biopsia lichid\u0103 reprezint\u0103 un instrument important al medicinei de precizie oncologice, fiind utilizat\u0103 at\u00e2t pentru alegerea tratamentului, c\u00e2t \u0219i pentru monitorizarea evolu\u021biei bolii.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Panel genetic somatic realizat din <strong>biopsie lichid\u0103 (liquid biopsy)<\/strong>, care utilizeaz\u0103 ADN tumoral circulant (ctDNA) din plasm\u0103 pentru identificarea muta\u021biilor somatice asociate cancerului de s\u00e2n. Testul ofer\u0103 informa\u021bii relevante pentru selec\u021bia terapiei \u021bintite, monitorizarea r\u0103spunsului la tratament \u0219i identificarea mecanismelor de rezisten\u021b\u0103 terapeutic\u0103.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3165,2876],"product_tag":[],"class_list":["post-27084","product","type-product","status-publish","product_cat-analize","product_cat-oncogenetica","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Panel genetic somatic realizat din biopsie lichid\u0103 (liquid biopsy), care utilizeaz\u0103 ADN tumoral circulant (ctDNA) din plasm\u0103 pentru identificarea muta\u021biilor somatice asociate cancerului de s\u00e2n. Testul ofer\u0103 informa\u021bii relevante pentru selec\u021bia terapiei \u021bintite, monitorizarea r\u0103spunsului la tratament \u0219i identificarea mecanismelor de rezisten\u021b\u0103 terapeutic\u0103.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/panel-genetic-somatic-cancer-san-din-biopsie-lichida-12-gene\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinica Sante - Laborator de Analize Medicale - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Panel genetic somatic cancer san din biopsie lichida - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:description\" content=\"Panel genetic somatic realizat din biopsie lichid\u0103 (liquid biopsy), care utilizeaz\u0103 ADN tumoral circulant (ctDNA) din plasm\u0103 pentru identificarea muta\u021biilor somatice asociate cancerului de s\u00e2n. 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