{"id":27079,"date":"2025-06-24T14:41:04","date_gmt":"2025-06-24T12:41:04","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/panel-cancere-ereditare-clarity-plus\/"},"modified":"2026-02-27T17:57:02","modified_gmt":"2026-02-27T15:57:02","slug":"panel-cancere-ereditare-clarity-plus","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/panel-cancere-ereditare-clarity-plus\/","title":{"rendered":"Panel cancere ereditare &#8211; Clarity plus"},"content":{"rendered":"<p><strong>Panelul Clarity Plus<\/strong> utilizeaz\u0103 tehnologia de \u00eenalt\u0103 rezolu\u021bie Next Generation Sequencing (NGS) pentru secven\u021bierea complet\u0103 a exoanelor \u0219i a regiunilor intron\u2013exon ale celor 53 de gene \u021bint\u0103.<\/p>\n<p>Testul permite detec\u021bia:<\/p>\n<\/p>\n<ul>\n<li>muta\u021biilor punctiforme (SNV)<\/li>\n<li>dele\u021biilor \u0219i duplica\u021biilor (CNV)<\/li>\n<li>inser\u021biilor \u0219i dele\u021biilor scurte (indels)<\/li>\n<\/ul>\n<p>Acoper\u0103 sindroamele genetice cel mai frecvent implicate \u00een cancerul ereditar, inclusiv:<\/p>\n<\/p>\n<ul>\n<li>Sindromul cancerului ereditar de s\u00e2n \u0219i ovar (BRCA1\/2, RAD51C\/D, PALB2)<\/li>\n<li>Sindromul Lynch (MLH1, MSH2, MSH6, PMS2, EPCAM)<\/li>\n<li>Sindromul Li-Fraumeni (TP53)<\/li>\n<li>Sindromul Peutz-Jeghers (STK11)<\/li>\n<li>Sindromul Cowden (PTEN)<\/li>\n<li>Polipoza adenomatoas\u0103 familial\u0103 (APC, MUTYH)<\/li>\n<li>Sindromul Von Hippel\u2013Lindau (VHL)<\/li>\n<li>Sindromul MEN1, precum \u0219i alte forme rare de predispozi\u021bie oncologic\u0103 ereditar\u0103<\/li>\n<\/ul>\n<p><strong>Afec\u021biuni sau simptome asociate<\/strong><\/p>\n<\/p>\n<p>Testul este relevant pentru evaluarea riscului \u00een:<\/p>\n<\/p>\n<ul>\n<li>Cancer de s\u00e2n \u0219i ovar ereditar<\/li>\n<li>Cancer colorectal ereditar \u0219i polipoze multiple<\/li>\n<li>Cancer pancreatic \u0219i gastric<\/li>\n<li>Cancer pulmonar \u0219i prostatic ereditar<\/li>\n<li>Melanom familial<\/li>\n<li>Tumori cerebrale, endometriale sau renale<\/li>\n<li>Neoplazii endocrine multiple (MEN1, RET)<\/li>\n<\/ul>\n<p><strong>Cui se adreseaz\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>Persoanelor cu istoric familial semnificativ (\u22652 rude de grad I\/II afectate)<\/li>\n<li>Pacien\u021bilor diagnostica\u021bi cu cancer la v\u00e2rst\u0103 t\u00e2n\u0103r\u0103 (&lt;50 ani)<\/li>\n<li>Pacien\u021bilor cu tumori multiple primare<\/li>\n<li>Femeilor cu cancer mamar triplu negativ diagnosticat \u00eenainte de 60 de ani<\/li>\n<li>Pacien\u021bilor cu rezultate suspecte la IHC (ex. MSI, deficit de MMR)<\/li>\n<li>Persoanelor care doresc o evaluare preventiv\u0103 a riscului genetic personal sau familial<\/li>\n<\/ul>\n<p><strong>Metodologie de testare<\/strong><\/p>\n<\/p>\n<ul>\n<li>Secven\u021biere genomic\u0103 complet\u0103 prin NGS<\/li>\n<li>Acoperire \u226599% a regiunilor codante ale celor 53 de gene<\/li>\n<li>Detec\u021bie SNV, CNV \u0219i indels<\/li>\n<li>Analiza variantelor conform ghidurilor ACMG\/AMP<\/li>\n<li>Confirmare prin Sanger, MLPA sau qPCR atunci c\u00e2nd este necesar<\/li>\n<\/ul>\n<p><strong>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>Identific\u0103 muta\u021biile ereditare care cresc riscul pentru cancere frecvente<\/li>\n<li>Permite monitorizare personalizat\u0103 \u0219i strategii de preven\u021bie (screening dedicat, chimiopreven\u021bie, chirurgie profilactic\u0103)<\/li>\n<li>Ofer\u0103 informa\u021bii pentru testarea rudelor (cascade testing)<\/li>\n<li>Ajut\u0103 la alegerea terapiilor \u021bintite (ex.: inhibitori PARP pentru BRCA1\/2, imunoterapie pentru MSI-H)<\/li>\n<li>Este considerat test de referin\u021b\u0103 \u00een oncogenetica preventiv\u0103 \u0219i personalizat\u0103<\/li>\n<\/ul>\n<p><strong>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/strong><\/p>\n<\/p>\n<ul>\n<li>Este un test de screening genetic, necesit\u00e2nd interpretare clinic\u0103 \u0219i consiliere genetic\u0103<\/li>\n<li>Nu detecteaz\u0103 variante mozaice cu frac\u021bie &lt;5%<\/li>\n<li>Nu detecteaz\u0103 muta\u021bii din regiuni neacoperite sau gene care nu sunt incluse \u00een panel<\/li>\n<li>Nu ofer\u0103 informa\u021bii despre risc epigenetic sau factorii de mediu<\/li>\n<li>Rezultatele sunt interpretate conform ghidurilor ACMG 2022<\/li>\n<\/ul>\n<p><strong>Tip prob\u0103<\/strong><\/p>\n<\/p>\n<ul>\n<li>S\u00e2nge periferic (2 \u00d7 4 ml EDTA)<\/li>\n<li>Alternativ: saliv\u0103 (kit dedicat)<\/li>\n<\/ul>\n<p><strong>Condi\u021bii pentru recoltare<\/strong><\/p>\n<\/p>\n<ul>\n<li>Recoltare standard, f\u0103r\u0103 repaus alimentar<\/li>\n<li>Proba se transport\u0103 la temperatura camerei, ambalat\u0103 corespunz\u0103tor<\/li>\n<li>Necesit\u0103 prescrip\u021bie medical\u0103 \u0219i consiliere genetic\u0103 pre-test<\/li>\n<\/ul>\n<p><strong>Analize asociate recomandate<\/strong><\/p>\n<\/p>\n<ul>\n<li>Consiliere genetic\u0103 pre \u0219i post-test<\/li>\n<li>Testare familial\u0103 direc\u021bionat\u0103<\/li>\n<li>Analiz\u0103 MSI \/ MMR pentru cancer colorectal<\/li>\n<li>Teste pentru instabilitate microsatelitar\u0103 (MSI-H) \u0219i expresia BRCA1\/2 \u00een tumori<\/li>\n<li>Teste suplimentare de confirmare: MLPA, FISH, Sanger<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p><strong>Panelul Clarity Plus<\/strong> \u2013 Cancere ereditare este un test genetic complex care analizeaz\u0103 simultan 53 de gene asociate cu cele mai frecvente sindroame de predispozi\u021bie ereditar\u0103 la cancer.<\/p>\n<\/p>\n<p>Prin identificarea muta\u021biilor patogene \u0219i probabil patogene implicate \u00een procesele de reparare a ADN-ului, proliferare celular\u0103 \u0219i control al ciclului celular, testul ofer\u0103 informa\u021bii esen\u021biale pentru preven\u021bia, diagnosticul precoce \u0219i managementul personalizat al riscului oncologic.<\/p>\n<\/p>\n<p><strong>Gene analizate<\/strong><\/p>\n<\/p>\n<p>Testul analizeaz\u0103 gene implicate \u00een predispozi\u021bia ereditar\u0103 la cancer, precum:<\/p>\n<\/p>\n<p><strong>BRCA1, BRCA2, ATM, CHEK2, PALB2, PTEN, TP53, CDH1, MLH1, MSH2, MSH6, PMS2, EPCAM, STK11, NF1, SMAD4, BMPR1A, APC, MUTYH, NBN, RAD51C, RAD51D, BARD1, BRIP1, CDKN2A, HOXB13, MEN1, POLE, POLD1, FANCA, FANCM, DICER1, RET, VHL, AXIN2, BAP1, RNF43, GREM1, GALNT12, SMARCA4, RAD50, PTCH1, ATR, FAM175A, GEN1, NTHL1, PPP2R2A, MRE11, MITF, FANCL, RAD51B.<\/strong><\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3165,2876],"product_tag":[],"class_list":["post-27079","product","type-product","status-publish","product_cat-analize","product_cat-oncogenetica","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Panelul Clarity Plus \u2013 Cancere ereditare este un test genetic complex care analizeaz\u0103 simultan 53 de gene asociate cu cele mai frecvente sindroame de predispozi\u021bie ereditar\u0103 la cancer.Prin identificarea muta\u021biilor patogene \u0219i probabil patogene implicate \u00een procesele de reparare a ADN-ului, proliferare celular\u0103 \u0219i control al ciclului celular, testul ofer\u0103 informa\u021bii esen\u021biale pentru preven\u021bia, diagnosticul precoce \u0219i managementul personalizat al riscului oncologic.Gene analizateTestul analizeaz\u0103 gene implicate \u00een predispozi\u021bia ereditar\u0103 la cancer, precum:BRCA1, BRCA2, ATM, CHEK2, PALB2, PTEN, TP53, CDH1, MLH1, MSH2, MSH6, PMS2, EPCAM, STK11, NF1, SMAD4, BMPR1A, APC, MUTYH, NBN, RAD51C, RAD51D, BARD1, BRIP1, CDKN2A, HOXB13, MEN1, POLE, POLD1, FANCA, FANCM, DICER1, RET, VHL, AXIN2, BAP1, RNF43, GREM1, GALNT12, SMARCA4, RAD50, PTCH1, ATR, FAM175A, GEN1, NTHL1, PPP2R2A, MRE11, MITF, FANCL, RAD51B.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/panel-cancere-ereditare-clarity-plus\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinica Sante - Laborator de Analize Medicale - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Panel cancere ereditare \u2013 Clarity plus - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:description\" content=\"Panelul Clarity Plus \u2013 Cancere ereditare este un test genetic complex care analizeaz\u0103 simultan 53 de gene asociate cu cele mai frecvente sindroame de predispozi\u021bie ereditar\u0103 la cancer.Prin identificarea muta\u021biilor patogene \u0219i probabil patogene implicate \u00een procesele de reparare a ADN-ului, proliferare celular\u0103 \u0219i control al ciclului celular, testul ofer\u0103 informa\u021bii esen\u021biale pentru preven\u021bia, diagnosticul precoce \u0219i managementul personalizat al riscului oncologic.Gene analizateTestul analizeaz\u0103 gene implicate \u00een predispozi\u021bia ereditar\u0103 la cancer, precum:BRCA1, BRCA2, ATM, CHEK2, PALB2, PTEN, TP53, CDH1, MLH1, MSH2, MSH6, PMS2, EPCAM, STK11, NF1, SMAD4, BMPR1A, APC, MUTYH, NBN, RAD51C, RAD51D, BARD1, BRIP1, CDKN2A, HOXB13, MEN1, POLE, POLD1, FANCA, FANCM, DICER1, RET, VHL, AXIN2, BAP1, RNF43, GREM1, GALNT12, SMARCA4, RAD50, PTCH1, ATR, FAM175A, GEN1, NTHL1, PPP2R2A, MRE11, MITF, FANCL, RAD51B.\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/panel-cancere-ereditare-clarity-plus\/\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2025-06-24T12:41:04+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-02-27T15:57:02+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Panel cancere ereditare \u2013 Clarity plus - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Panelul Clarity Plus \u2013 Cancere ereditare este un test genetic complex care analizeaz\u0103 simultan 53 de gene asociate cu cele mai frecvente sindroame de predispozi\u021bie ereditar\u0103 la cancer.Prin identificarea muta\u021biilor patogene \u0219i probabil patogene implicate \u00een procesele de reparare a ADN-ului, proliferare celular\u0103 \u0219i control al ciclului celular, testul ofer\u0103 informa\u021bii esen\u021biale pentru preven\u021bia, diagnosticul precoce \u0219i managementul personalizat al riscului oncologic.Gene analizateTestul analizeaz\u0103 gene implicate \u00een predispozi\u021bia ereditar\u0103 la cancer, precum:BRCA1, BRCA2, ATM, CHEK2, PALB2, PTEN, TP53, CDH1, MLH1, MSH2, MSH6, PMS2, EPCAM, STK11, NF1, SMAD4, BMPR1A, APC, MUTYH, NBN, RAD51C, RAD51D, BARD1, BRIP1, CDKN2A, HOXB13, MEN1, POLE, POLD1, FANCA, FANCM, DICER1, RET, VHL, AXIN2, BAP1, RNF43, GREM1, GALNT12, SMARCA4, RAD50, PTCH1, ATR, FAM175A, GEN1, NTHL1, PPP2R2A, MRE11, MITF, FANCL, RAD51B.\" \/>\n\t\t<script type=\"application\/ld+json\" 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