{"id":26803,"date":"2025-06-24T14:24:12","date_gmt":"2025-06-24T12:24:12","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/detectia-mutatiilor-in-gena-braf-in-cancerul-pulmonar-5-mutatii-in-codonul-600-v600e-k-d-r-m-tesut-inclus-in-parafina\/"},"modified":"2026-02-27T17:53:44","modified_gmt":"2026-02-27T15:53:44","slug":"detectia-mutatiilor-in-gena-braf-in-cancerul-pulmonar-5-mutatii-in-codonul-600-v600e-k-d-r-m-tesut-inclus-in-parafina","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/detectia-mutatiilor-in-gena-braf-in-cancerul-pulmonar-5-mutatii-in-codonul-600-v600e-k-d-r-m-tesut-inclus-in-parafina\/","title":{"rendered":"Detectia mutatiilor in gena BRAF in cancerul pulmonar (5 mutatii in codonul 600: V600E\/K\/D\/R\/M) (tesut inclus in parafina)"},"content":{"rendered":"<p class=\"ql-align-justify\">La nivelul genei BRAF au fost descrise peste 300 de muta\u021bii, cele mai relevante pentru tumorigenez\u0103 fiind localizate la nivelul codonului 600. Din punct de vedere clinic, muta\u021bia V600E \u2013 \u0219i, mai rar, V600K sau V600D \u2013 este cea mai frecvent testat\u0103 \u00een NSCLC.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Testarea se efectueaz\u0103 \u00een cascad\u0103, fiind recomandat\u0103 pacien\u021bilor cu NSCLC EGFR wild-type, \u0219i este indicat s\u0103 fie realizat\u0103 din acela\u0219i bloc de parafin\u0103 sau e\u0219antion de ADN (dac\u0103 este disponibil) din care s-a efectuat \u0219i testarea EGFR.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\"><strong>Detec\u021bia muta\u021biilor BRAF<\/strong> este de importan\u021b\u0103 esen\u021bial\u0103 pentru stabilirea conduitei terapeutice la pacien\u021bii cu NSCLC. \u00cen acest scop au fost dezvoltate multiple tehnologii de diagnostic molecular, printre care \u0219i metoda Real-Time PCR, utilizat\u0103 \u00een cadrul laboratorului nostru.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Aceast\u0103 tehnic\u0103 permite identificarea precis\u0103 \u0219i rapid\u0103 a celor mai frecvente cinci muta\u021bii (V600E\/K\/D\/R\/M) din gena BRAF.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Biopsia tumoral\u0103 r\u0103m\u00e2ne abordarea preferat\u0103 pentru efectuarea test\u0103rii moleculare, \u00eens\u0103, \u00een aproximativ 30% dintre cazuri, nu sunt disponibile probe de \u021besut tumoral adecvate sau calitatea ADN-ului extras din \u021besutul fixat \u0219i inclus \u00een parafin\u0103 (FFPE) este insuficient\u0103 pentru analiza genetic\u0103.<\/p>\n<p class=\"ql-align-justify\">\n<p><strong>Afec\u021biuni \u0219i simptome asociate:<\/strong><\/p>\n<\/p>\n<p>Cancerul pulmonar este una dintre cele mai grave \u0219i frecvente forme de cancer, adesea depistat\u0103 tardiv din cauza simptomelor subtile sau absente \u00een stadiile incipiente.<\/p>\n<\/p>\n<p>Simptomele cancerului pulmonar variaz\u0103 de la o persoan\u0103 la alta \u0219i depind de localizarea tumorii, stadiul bolii \u0219i prezen\u021ba metastazelor. Unele persoane pot fi asimptomatice, iar multe dintre manifest\u0103ri pot fi confundate cu alte afec\u021biuni respiratorii comune (bron\u0219it\u0103, pneumonie).<\/p>\n<\/p>\n<p class=\"ql-align-justify\">Diagnosticarea timpurie este esen\u021bial\u0103 pentru cre\u0219terea \u0219anselor de tratament eficient \u0219i supravie\u021buire.<\/p>\n<p class=\"ql-align-justify\">\n<p><strong>Simptomele specifice ale cancerului pulmonar includ:<\/strong><\/p>\n<\/p>\n<ul>\n<li>tuse persistent\u0103 (uneori cu s\u00e2nge);<\/li>\n<li>durere toracic\u0103;<\/li>\n<li>respira\u021bie dificil\u0103 sau \u0219uier\u0103toare;<\/li>\n<li>r\u0103gu\u0219eal\u0103;<\/li>\n<li>umflarea fe\u021bei sau a g\u00e2tului.<\/li>\n<\/ul>\n<p><strong>Alte simptome posibile:<\/strong><\/p>\n<\/p>\n<ul>\n<li>pierdere inexplicabil\u0103 \u00een greutate;<\/li>\n<li>oboseal\u0103 accentuat\u0103;<\/li>\n<li>dureri de spate sau de um\u0103r;<\/li>\n<li>inflama\u021bia ganglionilor limfatici.<\/li>\n<\/ul>\n<p>Cancerul pulmonar este frecvent asociat cu alte afec\u021biuni pulmonare preexistente, cum ar fi boala pulmonar\u0103 obstructiv\u0103 cronic\u0103 (BPOC) \u0219i boala pulmonar\u0103 intersti\u021bial\u0103, care cresc riscul de apari\u021bie \u0219i complic\u0103 tratamentul.<\/p>\n<\/p>\n<p>De asemenea, pot ap\u0103rea sindroame paraneoplazice (complica\u021bii mediate imun sau prin secre\u021bia aberant\u0103 de hormoni), printre care:<\/p>\n<ul>\n<li>hipercalcemia,<\/li>\n<li>sindromul de secre\u021bie inadecvat\u0103 a hormonului antidiuretic (SIADH),<\/li>\n<li>sindroamele neurologice paraneoplazice, precum sindromul miastenic Lambert-Eaton.<\/li>\n<\/ul>\n<p><strong>Cui se adreseaz\u0103 analiza<\/strong><\/p>\n<\/p>\n<p><strong>Detec\u021bia muta\u021biilor BRAF<\/strong> \u00een cancerul pulmonar este recomandat\u0103 tuturor pacien\u021bilor cu NSCLC avansat non-scuamos \u2013 inclusiv adenocarcinom sau forme cu histologie mixt\u0103 (adeno-scuamoas\u0103) \u2013 precum \u0219i pacien\u021bilor cu carcinom scuamos nefum\u0103tori sau fo\u0219ti fum\u0103tori u\u0219ori.<\/p>\n<\/p>\n<p><strong>Analiza are ca scop:<\/strong><\/p>\n<\/p>\n<ul>\n<li>identificarea muta\u021biilor ac\u021bionabile, \u00een special BRAF V600E, care pot indica eligibilitatea pentru terapie \u021bintit\u0103 combinat\u0103 BRAF\/MEK;<\/li>\n<li>ghidarea deciziei terapeutice \u2013 determinarea celui mai eficient tratament, \u00eentruc\u00e2t pacien\u021bii cu muta\u021bii BRAF pot ob\u021bine un r\u0103spuns terapeutic superior la terapia \u021bintit\u0103 comparativ cu chimioterapia clasic\u0103.<\/li>\n<\/ul>\n<p><strong>Metodologie de testare<\/strong><\/p>\n<\/p>\n<p class=\"ql-align-justify\">Testul presupune extrac\u021bia ADN din \u021besut tumoral inclus \u00een parafin\u0103 (FFPE), urmat\u0103 de cuantificarea acestuia prin metode spectrofotometrice \u0219i fluorimetrice, \u00een vederea stabilirii calit\u0103\u021bii \u0219i a cantit\u0103\u021bii probei.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Ulterior, ADN-ul este amplificat prin tehnologie Real-Time PCR, metod\u0103 care permite detec\u021bia calitativ\u0103 a celor mai frecvente muta\u021bii \u00een codonul 600 al genei BRAF.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\"><strong>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/strong><\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">De\u0219i muta\u021biile BRAF sunt bine caracterizate \u00een alte tipuri de cancer (\u00een special melanom), \u00een cazul NSCLC datele privind impactul lor asupra prognosticului \u0219i r\u0103spunsului la tratament sunt \u00eenc\u0103 limitate, \u00een principal din cauza prevalen\u021bei sc\u0103zute a cazurilor BRAF-pozitive.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\"><strong>Beneficiile clinice ale test\u0103rii BRAF \u00een NSCLC includ:<\/strong><\/p>\n<p class=\"ql-align-justify\">\n<ul>\n<li>Eligibilitatea pentru terapie \u021bintit\u0103 \u2013 asociat\u0103 cu rezultate superioare fa\u021b\u0103 de chimioterapia conven\u021bional\u0103, \u00een special \u00een stadiile avansate (rata de r\u0103spuns favorabil \u0219i supravie\u021buire f\u0103r\u0103 progresie mai mare).<\/li>\n<li> Tipul specific de muta\u021bie BRAF (V600E vs. non-V600E) poate influen\u021ba sensibilitatea la tratament: muta\u021bia V600E r\u0103spunde mai bine la inhibitorii standard, \u00een timp ce muta\u021biile non-V600E pot fi rezistente la inhibitorii BRAF, dar pot r\u0103spunde la inhibitorii MEK.<\/li>\n<li>Implica\u021bii prognostice \u2013 pacien\u021bii cu muta\u021bii BRAF V600E, afla\u021bi \u00een stadii avansate de boal\u0103 \u0219i eligibili pentru terapie \u021bintit\u0103, prezint\u0103 o rat\u0103 de supravie\u021buire semnificativ mai crescut\u0103 comparativ cu cei netesta\u021bi sau trata\u021bi prin chimioterapie standard.<\/li>\n<\/ul>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\"><strong>Particularit\u0103\u021bi<\/strong><\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Muta\u021biile BRAF \u00een NSCLC prezint\u0103 urm\u0103toarele caracteristici:<\/p>\n<p class=\"ql-align-justify\">\n<ul>\n<li>sunt cel mai frecvent \u00eent\u00e2lnite \u00een:\n<ul>\n<li>adenocarcinomul pulmonar (2\u20134% dintre cazuri),<\/li>\n<li>nefum\u0103tori,<\/li>\n<li>sexul feminin,<\/li>\n<li>subtipuri histologice agresive (ex. adenocarcinom micropapilar);<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>muta\u021bia V600E:\n<ul>\n<li>este mai pu\u021bin frecvent\u0103 comparativ cu melanomul;<\/li>\n<li>este, \u00een general, mutual exclusiv\u0103 cu alte muta\u021bii ac\u021bionabile din NSCLC;<\/li>\n<li>se asociaz\u0103 cu prognostic mai bun \u00een stadiile avansate, comparativ cu muta\u021biile non-V600;<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>muta\u021biile non-V600:\n<ul>\n<li>reprezint\u0103 aproximativ 50% din totalul cazurilor BRAF-pozitive;<\/li>\n<li>pot fi rezistente la terapiile BRAF, dar unele pot fi sensibile la inhibitorii MEK;<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>anumite muta\u021bii pot coexista cu muta\u021bii KRAS, ceea ce poate influen\u021ba r\u0103spunsul la tratament \u0219i alegerea terapiei \u021bintite.<\/li>\n<\/ul>\n<p class=\"ql-align-justify\"><strong>Particularit\u0103\u021bi tehnice ale metodei Real-Time PCR<\/strong><\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Detec\u021bia muta\u021biilor \u00een gena BRAF se realizeaz\u0103 prin metoda Real-Time PCR, o tehnic\u0103 relativ simpl\u0103, cu urm\u0103toarele caracteristici:<\/p>\n<p class=\"ql-align-justify\">\n<ul>\n<li>cost redus \u0219i timp scurt de analiz\u0103, comparativ cu tehnologia NGS;<\/li>\n<li>sensibilitate crescut\u0103 \u2013 permite amplificarea chiar \u0219i a unor cantit\u0103\u021bi reduse de ADN, aspect esen\u021bial \u00een analiza probelor FFPE, unde ADN-ul este adesea limitat;<\/li>\n<li>specificitate ridicat\u0103 \u2013 asigur\u0103 detec\u021bia muta\u021biilor prezente \u00eentr-o frecven\u021b\u0103 redus\u0103 \u00een proba tumoral\u0103;<\/li>\n<li>robuste\u021be \u2013 permite ob\u021binerea de rezultate fiabile chiar \u0219i \u00een condi\u021biile unei calit\u0103\u021bi suboptime a ADN-ului genomic tumoral, caracteristic probelor FFPE (fragmente scurte de ADN);<\/li>\n<li>limit\u0103 de detec\u021bie sc\u0103zut\u0103 \u2013 permite identificarea variantelor cu frecven\u021b\u0103 alelic\u0103 redus\u0103 (p\u00e2n\u0103 la 1% ADN mutant \u00eentr-un fond de 99% ADN normal), inclusiv \u00een biopsii cu con\u021binut tumoral mic.<\/li>\n<\/ul>\n<p><strong>Limit\u0103ri<\/strong><\/p>\n<\/p>\n<ul>\n<li>Testul vizeaz\u0103 exclusiv muta\u021biile BRAF V600. Metoda utilizat\u0103 nu permite identificarea muta\u021biilor din exonul 11 al genei BRAF, care pot fi relativ frecvente \u00een NSCLC. Av\u00e2nd \u00een vedere diversitatea muta\u021biilor posibile, caracterizarea complet\u0103 a genomului tumoral este important\u0103 pentru identificarea precis\u0103 a variantei muta\u021bionale \u0219i pentru ghidarea corect\u0103 a deciziei terapeutice;<\/li>\n<li>Probele de calitate redus\u0103 (material tisular insuficient, procent tumoral &lt;2%, concentra\u021bie ADN &lt;1 ng, ADN degradat sau denaturat \u00een urma procesului de includere \u00een parafin\u0103) pot genera date de calitate inferioar\u0103, necorespunz\u0103toare ob\u021binerii unui rezultat concludent;<\/li>\n<li>Rezultatele negative (muta\u021bii nedetectate) nu exclud prezen\u021ba unor muta\u021bii care nu sunt incluse \u00een kitul utilizat pentru testare.<\/li>\n<\/ul>\n<p><strong>Recoltare \u0219i condi\u021bii<\/strong><\/p>\n<\/p>\n<p>Testul se efectueaz\u0103 pe sec\u021biuni de \u021besut tumoral inclus \u00een parafin\u0103 (FFPE), cu o grosime de aproximativ 5 microni, etalate pe lam\u0103 microscopic\u0103 f\u0103r\u0103 colorare prin metoda clasic\u0103 hematoxilin\u0103-eozin\u0103.<\/p>\n<\/p>\n<p>Medicul anatomo-patolog selecteaz\u0103 zona cu densitate celular\u0103 tumoral\u0103 crescut\u0103, evit\u00e2nd regiunile cu necroz\u0103, fibroz\u0103 sau infiltrat inflamator, pentru a asigura calitatea optim\u0103 a probei de ADN.<\/p>\n<\/p>\n<p class=\"ql-align-justify\">Testarea genetic\u0103 pentru detec\u021bia muta\u021biilor \u00een gena BRAF se realizeaz\u0103 prin metoda Real-Time PCR, care permite identificarea precis\u0103 \u0219i rapid\u0103 a muta\u021biilor punctiforme relevante.<\/p>\n<p class=\"ql-align-justify\">\n<p><strong>Analize asociate recomandate<\/strong><\/p>\n<\/p>\n<ul>\n<li>Detec\u021bia muta\u021biei EGFR T790M \u00een plasm\u0103<\/li>\n<li>EGFR FISH \u2013 tumori solide<\/li>\n<li>Panel genetic somatic cancer pulmonar (biopsie lichid\u0103, 12 gene)<\/li>\n<li>Panel genetic somatic pan-cancer (biopsie lichid\u0103, 52 gene)<\/li>\n<li>Panel 52 gene relevante \u00een tumori solide \u2013 Oncomine Focus Assay ADN + ARN<\/li>\n<li>Panel genetic somatic cancer pulmonar [POUM1]<\/li>\n<li>Panel genetic somatic cancer pulmonar [POUM2]<\/li>\n<li>Solid Tumor Panel \u2013 panel genetic somatic pentru tumori solide (149 gene \u2013 multiorgan)<\/li>\n<\/ul>\n<p class=\"ql-align-justify\">\n<\/p>\n<\/p>\n<p class=\"ql-align-justify\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p class=\"ql-align-justify\"><strong>Cancerul pulmonar non-microcelular (NSCLC)<\/strong> reprezint\u0103 principala cauz\u0103 de mortalitate oncologic\u0103 la nivel mondial.<\/p>\n<p class=\"ql-align-justify\">Identificarea muta\u021biilor somatice \u00een diverse oncogene driver (<em>EGFR, KRAS, BRAF<\/em> etc.), \u00een special \u00een adenocarcinomul pulmonar \u2013 cel mai frecvent subtip de NSCLC \u2013 a avut un impact major asupra op\u021biunilor terapeutice \u0219i a prognosticului pacien\u021bilor.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\"><strong>Muta\u021biile genei BRAF <\/strong>sunt identificate la aproximativ 2\u20135% dintre pacien\u021bii cu NSCLC \u0219i sunt mutual exclusive fa\u021b\u0103 de muta\u021biile din alte oncogene driver. Aceste muta\u021bii contribuie la carcinogenez\u0103 \u0219i la progresia tumoral\u0103.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Dintre variantele BRAF, cea mai frecvent\u0103 este muta\u021bia activatoare BRAF V600E, prezent\u0103 \u00een aproximativ 1\u20133% dintre cazurile de NSCLC. Pentru ace\u0219ti pacien\u021bi, combinarea inhibitorilor BRAF cu inhibitorii MEK a fost aprobat\u0103 de FDA ca terapie \u021bintit\u0103, demonstr\u00e2nd \u00eembun\u0103t\u0103\u021biri semnificative \u00een rata de r\u0103spuns, supravie\u021buirea f\u0103r\u0103 progresie \u0219i supravie\u021buirea general\u0103.<\/p>\n<p class=\"ql-align-justify\">\n<p class=\"ql-align-justify\">Analiza se realizeaz\u0103 prin tehnologie Real-Time PCR, care permite detec\u021bia calitativ\u0103 a celor cinci muta\u021bii (V600E\/K\/D\/R\/M) localizate \u00een exonul 15, codonul 600 al genei BRAF.<\/p><\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3165,2876],"product_tag":[],"class_list":["post-26803","product","type-product","status-publish","product_cat-analize","product_cat-oncogenetica","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Cancerul pulmonar non-microcelular (NSCLC) reprezint\u0103 principala cauz\u0103 de mortalitate oncologic\u0103 la nivel mondial.Identificarea muta\u021biilor somatice \u00een diverse oncogene driver (EGFR, KRAS, BRAF etc.), \u00een special \u00een adenocarcinomul pulmonar \u2013 cel mai frecvent subtip de NSCLC \u2013 a avut un impact major asupra op\u021biunilor terapeutice \u0219i a prognosticului pacien\u021bilor.Muta\u021biile genei BRAF sunt identificate la aproximativ 2\u20135% dintre pacien\u021bii cu NSCLC \u0219i sunt mutual exclusive fa\u021b\u0103 de muta\u021biile din alte oncogene driver. Aceste muta\u021bii contribuie la carcinogenez\u0103 \u0219i la progresia tumoral\u0103.Dintre variantele BRAF, cea mai frecvent\u0103 este muta\u021bia activatoare BRAF V600E, prezent\u0103 \u00een aproximativ 1\u20133% dintre cazurile de NSCLC. Pentru ace\u0219ti pacien\u021bi, combinarea inhibitorilor BRAF cu inhibitorii MEK a fost aprobat\u0103 de FDA ca terapie \u021bintit\u0103, demonstr\u00e2nd \u00eembun\u0103t\u0103\u021biri semnificative \u00een rata de r\u0103spuns, supravie\u021buirea f\u0103r\u0103 progresie \u0219i supravie\u021buirea general\u0103.Analiza se realizeaz\u0103 prin tehnologie Real-Time PCR, care permite detec\u021bia calitativ\u0103 a celor cinci muta\u021bii (V600E\/K\/D\/R\/M) localizate \u00een exonul 15, codonul 600 al genei BRAF.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/detectia-mutatiilor-in-gena-braf-in-cancerul-pulmonar-5-mutatii-in-codonul-600-v600e-k-d-r-m-tesut-inclus-in-parafina\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinica Sante - Laborator de Analize Medicale - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Detectia mutatiilor in gena BRAF in cancerul pulmonar (5 mutatii in codonul 600: V600E\/K\/D\/R\/M) (tesut inclus in parafina) - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:description\" content=\"Cancerul pulmonar non-microcelular (NSCLC) reprezint\u0103 principala cauz\u0103 de mortalitate oncologic\u0103 la nivel mondial.Identificarea muta\u021biilor somatice \u00een diverse oncogene driver (EGFR, KRAS, BRAF etc.), \u00een special \u00een adenocarcinomul pulmonar \u2013 cel mai frecvent subtip de NSCLC \u2013 a avut un impact major asupra op\u021biunilor terapeutice \u0219i a prognosticului pacien\u021bilor.Muta\u021biile genei BRAF sunt identificate la aproximativ 2\u20135% dintre pacien\u021bii cu NSCLC \u0219i sunt mutual exclusive fa\u021b\u0103 de muta\u021biile din alte oncogene driver. Aceste muta\u021bii contribuie la carcinogenez\u0103 \u0219i la progresia tumoral\u0103.Dintre variantele BRAF, cea mai frecvent\u0103 este muta\u021bia activatoare BRAF V600E, prezent\u0103 \u00een aproximativ 1\u20133% dintre cazurile de NSCLC. Pentru ace\u0219ti pacien\u021bi, combinarea inhibitorilor BRAF cu inhibitorii MEK a fost aprobat\u0103 de FDA ca terapie \u021bintit\u0103, demonstr\u00e2nd \u00eembun\u0103t\u0103\u021biri semnificative \u00een rata de r\u0103spuns, supravie\u021buirea f\u0103r\u0103 progresie \u0219i supravie\u021buirea general\u0103.Analiza se realizeaz\u0103 prin tehnologie Real-Time PCR, care permite detec\u021bia calitativ\u0103 a celor cinci muta\u021bii (V600E\/K\/D\/R\/M) localizate \u00een exonul 15, codonul 600 al genei BRAF.\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/detectia-mutatiilor-in-gena-braf-in-cancerul-pulmonar-5-mutatii-in-codonul-600-v600e-k-d-r-m-tesut-inclus-in-parafina\/\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2025-06-24T12:24:12+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-02-27T15:53:44+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Detectia mutatiilor in gena BRAF in cancerul pulmonar (5 mutatii in codonul 600: V600E\/K\/D\/R\/M) (tesut inclus in parafina) - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Cancerul pulmonar non-microcelular (NSCLC) reprezint\u0103 principala cauz\u0103 de mortalitate oncologic\u0103 la nivel mondial.Identificarea muta\u021biilor somatice \u00een diverse oncogene driver (EGFR, KRAS, BRAF etc.), \u00een special \u00een adenocarcinomul pulmonar \u2013 cel mai frecvent subtip de NSCLC \u2013 a avut un impact major asupra op\u021biunilor terapeutice \u0219i a prognosticului pacien\u021bilor.Muta\u021biile genei BRAF sunt identificate la aproximativ 2\u20135% dintre pacien\u021bii cu NSCLC \u0219i sunt mutual exclusive fa\u021b\u0103 de muta\u021biile din alte oncogene driver. Aceste muta\u021bii contribuie la carcinogenez\u0103 \u0219i la progresia tumoral\u0103.Dintre variantele BRAF, cea mai frecvent\u0103 este muta\u021bia activatoare BRAF V600E, prezent\u0103 \u00een aproximativ 1\u20133% dintre cazurile de NSCLC. 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