{"id":26800,"date":"2025-06-24T15:24:00","date_gmt":"2025-06-24T12:24:00","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/panel-imunohistochimie-ihc-mmr-msi-colon-mlh1-msh1-msh6-pms2-p53\/"},"modified":"2026-06-16T11:26:12","modified_gmt":"2026-06-16T08:26:12","slug":"panel-imunohistochimie-ihc-mmr-msi-colon-mlh1-msh1-msh6-pms2-p53","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-anatomie-patologica\/panel-imunohistochimie-ihc-mmr-msi-colon-mlh1-msh1-msh6-pms2-p53\/","title":{"rendered":"Panel imunohistochimie &#8211; IHC MMR\/MSI colon\/gastric (MLH1, MSH2, MSH6, PMS2) +\/- p53"},"content":{"rendered":"<p>Acest panel imunohistochimic evalueaz\u0103 integritatea sistemului de reparare a nepotrivirilor ADN (MMR &#8211; mismatch repair), mecanism esen\u021bial pentru men\u021binerea stabilit\u0103\u021bii genomice.<\/p>\n<h3>Sistemul MMR este format din proteinele:<\/h3>\n<ul>\n<li>MLH1<\/li>\n<li>MSH2<\/li>\n<li>MSH6<\/li>\n<li>PMS2<\/li>\n<\/ul>\n<p>Pierderea expresiei uneia sau mai multor proteine MMR sugereaz\u0103 instabilitate microsatelitar\u0103 (MSI \u2013 microsatellite instability), un subtip molecular important de cancer colorectal.<\/p>\n<p>\u00cen anumite cazuri, se poate ad\u0103uga \u0219i markerul p53, util pentru evaluarea alter\u0103rilor suplimentare ale controlului ciclului celular \u0219i pentru o caracterizare biologic\u0103 mai complex\u0103 a tumorii.<\/p>\n<p>Acest panel este esen\u021bial \u00een oncologia modern\u0103, deoarece identific\u0103 pacien\u021bii cu suspiciune de sindrom Lynch, precum \u0219i pacien\u021bii care pot r\u0103spunde diferit la imunoterapie.<\/p>\n<h3>Afec\u021biuni sau simptome asociate<\/h3>\n<h3>Testul este utilizat \u00een:<\/h3>\n<ul>\n<li>Cancer colorectal (colon \u0219i rect)<\/li>\n<li>Polipi colonici cu displazie<\/li>\n<li>Suspiciune de sindrom Lynch (cancer ereditar colorectal non-polipozic)<\/li>\n<li>Tumori endometriale asociate sindromului Lynch<\/li>\n<li>Alte tumori solide asociate defectelor MMR<\/li>\n<li>Evaluarea instabilit\u0103\u021bii microsatelitare (MSI-H)<\/li>\n<\/ul>\n<h3>Cui se adreseaz\u0103<\/h3>\n<h3>Testarea se adreseaz\u0103:<\/h3>\n<ul>\n<li>Pacien\u021bilor diagnostica\u021bi cu cancer colorectal<\/li>\n<li>Pacien\u021bilor tineri cu cancer colorectal (sub 50 ani)<\/li>\n<li>Pacien\u021bilor cu istoric familial de cancer colorectal sau endometrial<\/li>\n<li>Cazurilor suspecte de sindrom Lynch<\/li>\n<li>Medicilor oncologi \u0219i gastroenterologi pentru decizii terapeutice<\/li>\n<li>Medicilor anatomopatologi pentru clasificare molecular\u0103<\/li>\n<\/ul>\n<h3>Metodologie de testare<\/h3>\n<ol>\n<li>Se selecteaz\u0103 blocul de parafin\u0103 (FFPE) reprezentativ tumoral<\/li>\n<li>Se realizeaz\u0103 sec\u021biuni histologice fine<\/li>\n<li>Se aplic\u0103 anticorpi pentru MLH1, MSH2, MSH6, PMS2 \u00b1 p53<\/li>\n<li>Se eviden\u021biaz\u0103 expresia nuclear\u0103 a proteinelor MMR<\/li>\n<li>Se analizeaz\u0103 pierderea sau conservarea expresiei proteinelor<\/li>\n<li>Se coreleaz\u0103 rezultatele \u00eentre ele \u0219i cu morfologia tumorii<\/li>\n<li>Se emite raportul imunohistochimic final<\/li>\n<\/ol>\n<h3>Beneficii \u0219i importan\u021ba clinic\u0103<\/h3>\n<ul>\n<li>Identific\u0103 instabilitatea microsatelitar\u0103 (MSI)<\/li>\n<li>Ajut\u0103 la selectarea pacien\u021bilor care necesit\u0103 investiga\u021bii suplimentare pentru sindromul Lynch<\/li>\n<li>Ofer\u0103 informa\u021bii prognostice importante \u00een cancerul colorectal<\/li>\n<li>Ghideaz\u0103 decizia terapeutic\u0103 (inclusiv imunoterapie)<\/li>\n<li>Permite stratificarea riscului oncologic<\/li>\n<li>Contribuie la medicina personalizat\u0103<\/li>\n<li>Poate influen\u021ba recomand\u0103rile de screening familial<\/li>\n<\/ul>\n<h3>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/h3>\n<h3>Particularit\u0103\u021bi<\/h3>\n<ul>\n<li>Reprezint\u0103 metoda standard de screening pentru deficitul MMR<\/li>\n<li>Are valoare prognostic\u0103 \u0219i predictiv\u0103 important\u0103<\/li>\n<li>Este recomandat \u00een ghidurile interna\u021bionale pentru cancer colorectal<\/li>\n<li>Poate fi completat de teste moleculare MSI<\/li>\n<\/ul>\n<h3>Limit\u0103ri<\/h3>\n<ul>\n<li>Nu toate cazurile MSI sunt detectate exclusiv prin IHC<\/li>\n<li>Rezultatele pot necesita confirmare molecular\u0103 (PCR\/NGS)<\/li>\n<li>Expresia poate fi heterogen\u0103 \u00een unele tumori<\/li>\n<li>Depinde de calitatea materialului tisular<\/li>\n<\/ul>\n<h3>Indica\u021bii de testare<\/h3>\n<ul>\n<li>Cancer colorectal nou diagnosticat<\/li>\n<li>Suspiciune de sindrom Lynch<\/li>\n<li>Cancer colorectal la pacient t\u00e2n\u0103r<\/li>\n<li>Istoric familial sugestiv de cancer ereditar<\/li>\n<li>Tumori cu morfologie sugestiv\u0103 MSI<\/li>\n<li>Decizie terapeutic\u0103 pentru imunoterapie<\/li>\n<li>Evaluare prognostic\u0103 \u00een cancerul colorectal<\/li>\n<\/ul>\n<h3>Interpretarea rezultatelor<\/h3>\n<h3>Sistem MMR normal (proficient \/ pMMR)<\/h3>\n<ul>\n<li>Expresie nuclear\u0103 p\u0103strat\u0103 pentru toate proteinele (MLH1, MSH2, MSH6, PMS2)<\/li>\n<li>Sugereaz\u0103 stabilitate microsatelitar\u0103 (MSS)<\/li>\n<\/ul>\n<h3>Deficit MMR (dMMR)<\/h3>\n<ul>\n<li>Pierdere de expresie pentru una sau mai multe proteine<\/li>\n<li>Sugereaz\u0103 instabilitate microsatelitar\u0103 (MSI-H)<\/li>\n<li>Necesit\u0103 corelare pentru identificarea cauzei (sporadic\u0103 vs ereditar\u0103)<\/li>\n<\/ul>\n<h3>p53 (op\u021bional)<\/h3>\n<ul>\n<li>Pattern de expresie normal sau mutant (overexpresie sau pierdere complet\u0103)<\/li>\n<li>Ofer\u0103 informa\u021bii suplimentare despre agresivitatea tumoral\u0103<\/li>\n<\/ul>\n<p>Interpretarea final\u0103 este realizat\u0103 de medicul anatomopatolog \u00een corela\u021bie cu datele clinice \u0219i eventual testarea genetic\u0103.<\/p>\n<h3>Raportarea conform ghidurilor<\/h3>\n<ul>\n<li>Ghidurile ASCO \u0219i NCCN pentru cancer colorectal<\/li>\n<li>Recomand\u0103rile OMS pentru tumori digestive<\/li>\n<li>Standardele interna\u021bionale pentru testarea MMR\/MSI<\/li>\n<li>Protocoale de diagnostic pentru sindrom Lynch<\/li>\n<\/ul>\n<h3>Factori care pot influen\u021ba rezultatul<\/h3>\n<ul>\n<li>Fixarea necorespunz\u0103toare a \u021besutului<\/li>\n<li>Necroza tumoral\u0103<\/li>\n<li>Heterogenitatea expresiei proteice<\/li>\n<li>Calitatea blocului FFPE<\/li>\n<li>Artefacte de procesare histologic\u0103<\/li>\n<li>Timpul de la recoltare la fixare<\/li>\n<\/ul>\n<h3>Condi\u021bii pentru recoltare<\/h3>\n<ul>\n<li>Recoltare prin biopsie sau pies\u0103 operatorie<\/li>\n<li>Fixare imediat\u0103 \u00een formalin\u0103 tamponat\u0103 10%<\/li>\n<li>Evitarea \u00eent\u00e2rzierii fix\u0103rii<\/li>\n<\/ul>\n<h3>Specimen de recoltare<\/h3>\n<ul>\n<li>\u021aesut tumoral colorectal inclus \u00een parafin\u0103 (FFPE)<\/li>\n<li>Biopsii endoscopice sau piese chirurgicale<\/li>\n<\/ul>\n<h3>Prob\u0103<\/h3>\n<ul>\n<li>Blocuri de parafin\u0103 (FFPE) reprezentative tumoral<\/li>\n<li>Lame histologice dac\u0103 sunt solicitate<\/li>\n<\/ul>\n<h3>Stabilitate<\/h3>\n<ul>\n<li>Blocurile FFPE sunt stabile pe termen lung<\/li>\n<li>Expresia antigenic\u0103 poate sc\u0103dea \u00een timp \u00een condi\u021bii neoptime<\/li>\n<li>Calitatea fix\u0103rii influen\u021beaz\u0103 semnificativ rezultatul<\/li>\n<\/ul>\n<h3>Analize asociate recomandate<\/h3>\n<ul>\n<li>Testare MSI prin PCR sau NGS<\/li>\n<li>Panel genetic pentru sindrom Lynch (MLH1, MSH2, MSH6, PMS2 germinal)<\/li>\n<li>Examen histopatologic standard<\/li>\n<li>KRAS \/ NRAS \/ BRAF muta\u021bii<\/li>\n<li>Testare PD-L1 (\u00een cazuri selectate)<\/li>\n<li>Profil molecular tumoral extins (NGS)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Panelul imunohistochimic MMR\/MSI pentru colon este o analiz\u0103 utilizat\u0103 pentru evaluarea instabilit\u0103\u021bii microsatelitare \u0219i a statusului sistemului de reparare a erorilor ADN (Mismatch Repair \u2013 MMR). Include markerii MLH1, MSH2, MSH6 \u0219i PMS2, cu posibilitatea ad\u0103ug\u0103rii p53 pentru evaluare suplimentar\u0103. Testul are rol esen\u021bial \u00een diagnosticul, prognosticul \u0219i alegerea tratamentului \u00een cancerul colorectal.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3168,2876],"product_tag":[],"class_list":["post-26800","product","type-product","status-publish","product_cat-analize","product_cat-anatomie-patologica","product_cat-serviciu-laborator","pa_medical-conditions-cancer-colorectal","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"Panelul imunohistochimic MMR\/MSI pentru colon este o analiz\u0103 utilizat\u0103 pentru evaluarea instabilit\u0103\u021bii microsatelitare \u0219i a statusului sistemului de reparare a erorilor ADN (Mismatch Repair \u2013 MMR). Include markerii MLH1, MSH2, MSH6 \u0219i PMS2, cu posibilitatea ad\u0103ug\u0103rii p53 pentru evaluare suplimentar\u0103. 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Include markerii MLH1, MSH2, MSH6 \u0219i PMS2, cu posibilitatea ad\u0103ug\u0103rii p53 pentru evaluare suplimentar\u0103. 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Include markerii MLH1, MSH2, MSH6 \u0219i PMS2, cu posibilitatea ad\u0103ug\u0103rii p53 pentru evaluare suplimentar\u0103. Testul are rol esen\u021bial \u00een diagnosticul, prognosticul \u0219i alegerea tratamentului \u00een cancerul colorectal.\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-anatomie-patologica\\\/panel-imunohistochimie-ihc-mmr-msi-colon-mlh1-msh1-msh6-pms2-p53\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro#listItem\",\"position\":1,\"name\":\"Prima pagin\\u0103\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"name\":\"Analize Medicale\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"position\":2,\"name\":\"Analize Medicale\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"name\":\"Analize\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro#listItem\",\"name\":\"Prima pagin\\u0103\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"position\":3,\"name\":\"Analize\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"name\":\"Serviciu laborator\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"name\":\"Analize Medicale\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"position\":4,\"name\":\"Serviciu laborator\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-anatomie-patologica\\\/#listItem\",\"name\":\"Anatomie patologic\\u0103\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"name\":\"Analize\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-anatomie-patologica\\\/#listItem\",\"position\":5,\"name\":\"Anatomie patologic\\u0103\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-anatomie-patologica\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-anatomie-patologica\\\/panel-imunohistochimie-ihc-mmr-msi-colon-mlh1-msh1-msh6-pms2-p53\\\/#listItem\",\"name\":\"Panel imunohistochimie &#8211; 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