{"id":26731,"date":"2025-06-24T15:19:39","date_gmt":"2025-06-24T12:19:39","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/intoleranta-primara-la-lactoza\/"},"modified":"2026-02-27T17:52:52","modified_gmt":"2026-02-27T15:52:52","slug":"intoleranta-primara-la-lactoza","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-diagnostic-genetic\/intoleranta-primara-la-lactoza\/","title":{"rendered":"Intoleranta primara la lactoza"},"content":{"rendered":"<p>Intoleran\u021ba la lactoz\u0103 este cauzat\u0103 de deficitul de lactaz\u0103, enzima care descompune lactoza \u00een intestinul sub\u021bire.<\/p>\n<\/p>\n<p>Exist\u0103 mai multe tipuri de intoleran\u021b\u0103 la lactoz\u0103:<\/p>\n<\/p>\n<ul>\n<li>primar\u0103 (hipolactazia) \u2013 cea mai frecvent\u0103 form\u0103, ereditar\u0103, cu transmitere autozomal recesiv\u0103; apare dup\u0103 v\u00e2rsta de 2 ani, prin sc\u0103derea fiziologic\u0103 a activit\u0103\u021bii lactazei;<\/li>\n<li>secundar\u0103 (dob\u00e2ndit\u0103) \u2013 temporar\u0103, asociat\u0103 cu afec\u021biuni intestinale sau medicamente, f\u0103r\u0103 transmitere ereditar\u0103;<\/li>\n<li>congenital\u0103 (alactazia) \u2013 extrem de rar\u0103, prezent\u0103 de la na\u0219tere;<\/li>\n<li>de dezvoltare \u2013 temporar\u0103, \u00eent\u00e2lnit\u0103 la copiii prematuri.<\/li>\n<\/ul>\n<p><strong>Mecanismul genetic al intoleran\u021bei primare:<\/strong><\/p>\n<\/p>\n<ul>\n<li>polimorfismul <strong>-13910 C&gt;T<\/strong> (\u00een amonte de gena <strong>LCT<\/strong>) determin\u0103 nivelul de expresie al lactazei:\n<ul>\n<li><strong>C\/C (homozigot)<\/strong> \u2192 predispozi\u021bie genetic\u0103 la intoleran\u021b\u0103 primar\u0103 la lactoz\u0103;<\/li>\n<li><strong>T\/C (heterozigot)<\/strong> \u2192 simptome u\u0219oare, activitate intermediar\u0103 a lactazei;<\/li>\n<li><strong>T\/T (homozigot)<\/strong> \u2192 toleran\u021b\u0103 la lactoz\u0103.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>alte polimorfisme, precum <strong>-22018 G&gt;A<\/strong>, pot influen\u021ba expresia lactazei \u0219i riscul de intoleran\u021b\u0103.<\/li>\n<\/ul>\n<p><strong>Simptome asociate:<\/strong><\/p>\n<\/p>\n<p>Simptomele apar c\u00e2teva ore dup\u0103 consumul de lactoz\u0103 \u0219i includ:<\/p>\n<\/p>\n<ul>\n<li>crampe abdominale;<\/li>\n<li>balonare;<\/li>\n<li>flatulen\u021b\u0103;<\/li>\n<li>grea\u021b\u0103;<\/li>\n<li>diaree;<\/li>\n<li>v\u0103rs\u0103turi ocazionale.<\/li>\n<\/ul>\n<p><strong>Cui se recomand\u0103 testarea genetic\u0103:<\/strong><\/p>\n<\/p>\n<ul>\n<li>persoanelor cu suspiciune de intoleran\u021b\u0103 primar\u0103 sau congenital\u0103 la lactoz\u0103;<\/li>\n<li>persoanelor cu simptome gastrointestinale dup\u0103 consumul de produse lactate;<\/li>\n<li>pentru diferen\u021bierea \u00eentre intoleran\u021ba primar\u0103 \u0219i cea secundar\u0103 (de exemplu, \u00een boala celiac\u0103, boala Crohn, colita ulceroas\u0103);<\/li>\n<li>\u00een caz de hipoglicemie neexplicat\u0103 sau probleme digestive recurente.<\/li>\n<\/ul>\n<p><strong>Metodologie de testare:<\/strong><\/p>\n<\/p>\n<ul>\n<li>proba utilizat\u0103: s\u00e2nge periferic total;<\/li>\n<li>testul detecteaz\u0103 polimorfismele LCT -13910 C&gt;T \u0219i -22018 G&gt;A prin Real-Time PCR;<\/li>\n<li>permite stabilirea predispozi\u021biei genetice la intoleran\u021ba primar\u0103 la lactoz\u0103, f\u0103r\u0103 a fi necesare teste invazive sau provoc\u0103ri alimentare.<\/li>\n<\/ul>\n<p><strong>Beneficii \u0219i importan\u021b\u0103 clinic\u0103:<\/strong><\/p>\n<\/p>\n<ul>\n<li>test neinvaziv, rapid \u0219i precis;<\/li>\n<li>permite diferen\u021bierea \u00eentre intoleran\u021ba primar\u0103 \u0219i cea secundar\u0103;<\/li>\n<li>evit\u0103 rezultate fals-pozitive sau fals-negative \u00eent\u00e2lnite \u00een metodele clasice (biopsie de jejun, test de toleran\u021b\u0103 la lactoz\u0103);<\/li>\n<li>ghideaz\u0103 managementul nutri\u021bional individual:\n<ul>\n<li>reducerea consumului de lactoz\u0103;<\/li>\n<li>diet\u0103 f\u0103r\u0103 lactoz\u0103 \u0219i evitarea produselor cu \u201elactoz\u0103 ascuns\u0103\u201d;<\/li>\n<li>suplimentarea cu vitamine \u0219i minerale pentru prevenirea osteoporozei \u0219i a fracturilor.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>Particularit\u0103\u021bi \u0219i limit\u0103ri:<\/strong><\/p>\n<\/p>\n<ul>\n<li>testul nu poate diagnostica intoleran\u021ba secundar\u0103 la lactoz\u0103, cauzat\u0103 de afec\u021biuni intestinale sau medicamente;<\/li>\n<li>rezultatul indic\u0103 doar predispozi\u021bia genetic\u0103, simptomele pot varia individual.<\/li>\n<\/ul>\n<\/p>\n<p><strong>Recoltare \u0219i condi\u021bii:<\/strong><\/p>\n<\/p>\n<ul>\n<li>recoltarea se poate face \u00een orice moment al zilei;<\/li>\n<li>nu necesit\u0103 post alimentar sau preg\u0103tire special\u0103.<\/li>\n<\/ul>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><strong>Testul genetic pentru intoleran\u021ba primar\u0103 la lactoz\u0103<\/strong> indic\u0103 predispozi\u021bia la simptome digestive dup\u0103 consumul de lactoz\u0103, principalul zah\u0103r din lapte. Analiza se efectueaz\u0103 din s\u00e2nge periferic total, utiliz\u00e2nd tehnica Real-Time PCR pentru identificarea polimorfismelor genetice asociate cu expresia genei LCT, care codific\u0103 enzima lactaz\u0103.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3166,2876],"product_tag":[],"class_list":{"0":"post-26731","1":"product","2":"type-product","3":"status-publish","5":"product_cat-analize","6":"product_cat-diagnostic-genetic","7":"product_cat-serviciu-laborator","8":"pa_conditii-medicale-afecti-sindrom-de-intestin-iritabil","10":"first","11":"instock","12":"sale","13":"virtual","14":"purchasable","15":"product-type-simple"},"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product\/26731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/media?parent=26731"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_brand?post=26731"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_cat?post=26731"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/product_tag?post=26731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}