{"id":26664,"date":"2025-06-24T15:15:25","date_gmt":"2025-06-24T12:15:25","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize-fara-categorie\/genotipare-interleukina-28b-il28b-polimorfismul-c-t-rs12979860\/"},"modified":"2026-06-30T17:29:38","modified_gmt":"2026-06-30T14:29:38","slug":"genotipare-interleukina-28b-il28b-polimorfismul-c-t-rs12979860","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-farmacogenetica-si-farmacogenomica\/genotipare-interleukina-28b-il28b-polimorfismul-c-t-rs12979860\/","title":{"rendered":"Genotipare Interleukina 28B (IL28B polimorfismul C\/T rs12979860)"},"content":{"rendered":"<p>Gena <strong>IL28B (Interleukina 28B, numit\u0103 \u0219i IFNL3)<\/strong> codific\u0103 o protein\u0103 implicat\u0103 \u00een r\u0103spunsul imun antiviral, \u00een special \u00een infec\u021bia cu virusul hepatitic C (HCV).<\/p>\n<h3>Polimorfismul rs12979860 prezint\u0103 trei genotipuri posibile:<\/h3>\n<ul>\n<li><strong>CC<\/strong> \u2013 asociat cu r\u0103spuns favorabil la tratament antiviral \u0219i rat\u0103 crescut\u0103 de clearance viral spontan<\/li>\n<li><strong>CT<\/strong> \u2013 r\u0103spuns intermediar<\/li>\n<li><strong>TT<\/strong> \u2013 asociat cu r\u0103spuns mai slab la tratament \u0219i clearance viral redus<\/li>\n<\/ul>\n<p>Acest marker genetic este utilizat ca <strong>factor predictiv al r\u0103spunsului terapeutic<\/strong>, \u00een special \u00een terapiile antivirale clasice (interferon + ribavirin\u0103), dar r\u0103m\u00e2ne relevant \u0219i \u00een contextul evalu\u0103rii imunogenetice a infec\u021biei cu HCV.<\/p>\n<h3>Indica\u021bii de testare<\/h3>\n<ul>\n<li>Hepatit\u0103 C cronic\u0103 (HCV)<\/li>\n<li>Evaluarea probabilit\u0103\u021bii de r\u0103spuns la tratament antiviral<\/li>\n<li>Decizie terapeutic\u0103 \u00een infec\u021bia cu HCV<\/li>\n<li>Stratificarea riscului de non-r\u0103spuns la terapie<\/li>\n<li>Evaluare prognostic\u0103 \u00een infec\u021bii virale cronice<\/li>\n<li>Medicin\u0103 personalizat\u0103 \u00een hepatologie<\/li>\n<\/ul>\n<h3>Cui se adreseaz\u0103<\/h3>\n<ul>\n<li>Pacien\u021bilor cu infec\u021bie cronic\u0103 HCV<\/li>\n<li>Medicilor gastroenterologi \u0219i hepatologi<\/li>\n<li>Speciali\u0219tilor \u00een boli infec\u021bioase<\/li>\n<li>Centrelor de tratament antiviral<\/li>\n<li>Pacien\u021bilor evalua\u021bi \u00eenainte de ini\u021bierea terapiei antivirale<\/li>\n<\/ul>\n<h3>Metodologie de testare<\/h3>\n<ul>\n<li>Extrac\u021bie ADN din s\u00e2nge periferic (EDTA)<\/li>\n<li>Genotipare IL28B rs12979860 prin PCR \u00een timp real (Real-Time PCR)<\/li>\n<li>Detectarea alelelor C \u0219i T<\/li>\n<li>Stabilirea genotipului: CC \/ CT \/ TT<\/li>\n<li>Interpretare clinic\u0103 \u00een contextul infec\u021biei HCV \u0219i al r\u0103spunsului antiviral<\/li>\n<\/ul>\n<h3>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/h3>\n<ul>\n<li>Estimeaz\u0103 probabilitatea de r\u0103spuns la tratament antiviral<\/li>\n<li>Ajut\u0103 la individualizarea terapiei \u00een hepatita C<\/li>\n<li>Sprijin\u0103 deciziile terapeutice \u00een medicina infec\u021bioas\u0103<\/li>\n<li>Ofer\u0103 informa\u021bii prognostice utile \u00eenainte de tratament<\/li>\n<li>Reduce expunerea inutil\u0103 la terapii cu eficien\u021b\u0103 sc\u0103zut\u0103<\/li>\n<li>Contribuie la medicina personalizat\u0103 \u00een hepatologie<\/li>\n<\/ul>\n<h3>Analize asociate recomandate<\/h3>\n<h3>Hepatit\u0103 viral\u0103<\/h3>\n<ul>\n<li>ARN VHC cantitativ (viral load)<\/li>\n<li>Genotipare virus hepatitic C<\/li>\n<li>ARN VHB cantitativ (dac\u0103 coinfec\u021bie)<\/li>\n<li>Antigen HBs, anti-HCV<\/li>\n<\/ul>\n<h3>Evaluare hepatic\u0103<\/h3>\n<ul>\n<li>ALT, AST, GGT<\/li>\n<li>Bilirubin\u0103 total\u0103 \u0219i frac\u021bionat\u0103<\/li>\n<li>FibroScan \/ elastografie hepatic\u0103<\/li>\n<li>Ecografie hepatic\u0103<\/li>\n<\/ul>\n<h3>Farmacogenetic\u0103 \/ r\u0103spuns terapeutic<\/h3>\n<ul>\n<li>Alte markere de r\u0103spuns antiviral (\u00een func\u021bie de protocol)<\/li>\n<li>Evaluare imunogenetic\u0103 extins\u0103 (la nevoie)<\/li>\n<\/ul>\n<h3>Prob\u0103 recoltat\u0103 \/ condi\u021bii analiz\u0103<\/h3>\n<ul>\n<li>S\u00e2nge integral EDTA<\/li>\n<li>Nu necesit\u0103 condi\u021bii speciale de recoltare<\/li>\n<\/ul>\n<h3>Documente necesare<\/h3>\n<ul>\n<li>Recomandare medical\u0103<\/li>\n<li>Diagnostic de hepatit\u0103 C cronic\u0103<\/li>\n<li>Date privind tratamentul antiviral (dac\u0103 exist\u0103)<\/li>\n<\/ul>\n<h3>Denumiri alternative<\/h3>\n<ul>\n<li>IL28B genotyping<\/li>\n<li>IFNL3 polymorphism test<\/li>\n<li>rs12979860 IL28B test<\/li>\n<li>Hepatitis C response genetic test<\/li>\n<li>Interferon lambda 3 polymorphism analysis<\/li>\n<li>HCV treatment response genetic marker<\/li>\n<li>IL28B CT polymorphism test<\/li>\n<li>Pharmacogenetic hepatitis C test<\/li>\n<li>Viral response IL28B genotyping<\/li>\n<li>Biomnis IL28B assay<\/li>\n<\/ul>\n<h3>Particularit\u0103\u021bi ale testului<\/h3>\n<p>Polimorfismul <strong>IL28B rs12979860<\/strong> este un marker genetic utilizat pentru estimarea r\u0103spunsului imun antiviral \u00een infec\u021bia cu virus hepatitic C. De\u0219i importan\u021ba sa a fost mai mare \u00een era terapiilor bazate pe interferon, testul r\u0103m\u00e2ne relevant \u00een evaluarea prognostic\u0103 \u0219i \u00een \u00een\u021belegerea variabilit\u0103\u021bii individuale a r\u0103spunsului imun. Interpretarea trebuie realizat\u0103 \u00een context clinic \u0219i virologic complet.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Analiz\u0103 genetic\u0103 ce determin\u0103 polimorfismul <strong>IL28B (rs12979860)<\/strong>, utilizat \u00een special pentru evaluarea <strong>r\u0103spunsului la tratamentul antiviral \u00een hepatita C cronic\u0103<\/strong>. Testul are valoare prognostic\u0103 \u00een medicina infec\u021bioas\u0103.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3226,2876],"product_tag":[],"class_list":["post-26664","product","type-product","status-publish","product_cat-analize","product_cat-farmacogenetica-si-farmacogenomica","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Analiz\u0103 genetic\u0103 ce determin\u0103 polimorfismul IL28B (rs12979860), utilizat \u00een special pentru evaluarea r\u0103spunsului la tratamentul antiviral \u00een hepatita C cronic\u0103. 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