{"id":144468,"date":"2026-11-02T10:47:06","date_gmt":"2026-11-02T08:47:06","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize\/acizi-organici-in-urina\/"},"modified":"2026-11-03T16:43:08","modified_gmt":"2026-11-03T14:43:08","slug":"acizi-organici-in-urina","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-biochimie\/acizi-organici-in-urina\/","title":{"rendered":"Acizi organici \u00een urin\u0103"},"content":{"rendered":"<p>Acizii organici sunt compu\u0219i rezulta\u021bi din numeroase reac\u021bii biochimice care au loc \u00een organism. Ace\u0219tia pot reprezenta intermediari sau produ\u0219i finali ai metabolismului glucidelor, lipidelor, aminoacizilor \u0219i altor substan\u021be. O parte dintre ace\u0219ti compu\u0219i sunt elimina\u021bi prin urin\u0103, iar determinarea lor poate furniza informa\u021bii despre anumite procese metabolice.<\/p>\n<p>Profilul extins al acizilor organici urinari include peste 95 de metaboli\u021bi, grupa\u021bi \u00een categorii corespunz\u0103toare unor c\u0103i biochimice diferite.<\/p>\n<p>Analiza poate furniza informa\u021bii despre:<\/p>\n<ul>\n<li>metabolismul aminoacizilor \u0219i al acizilor gra\u0219i;<\/li>\n<li>metabolismul energetic \u0219i intermediarii ciclului Krebs;<\/li>\n<li>metaboli\u021bi asocia\u021bi utiliz\u0103rii anumitor vitamine \u0219i cofactori;<\/li>\n<li>metaboli\u021bi rezulta\u021bi din degradarea catecolaminelor \u0219i serotoninei;<\/li>\n<li>compu\u0219i care pot proveni din activitatea metabolic\u0103 a microorganismelor;<\/li>\n<li>metabolismul oxala\u021bilor;<\/li>\n<li>anumite c\u0103i metabolice asociate folatului \u0219i metabolismului compu\u0219ilor cu un atom de carbon;<\/li>\n<li>modific\u0103ri biochimice care pot necesita investigarea unor tulbur\u0103ri metabolice ereditare.<\/li>\n<\/ul>\n<p>Profilul ofer\u0103 o evaluare biochimic\u0103 extins\u0103, \u00eens\u0103 nu m\u0103soar\u0103 direct func\u021bia mitocondrial\u0103, compozi\u021bia microbiomului intestinal, activitatea neurotransmi\u021b\u0103torilor cerebrali sau capacitatea organismului de eliminare a substan\u021belor toxice.<\/p>\n<p><strong>Parametrii analiza\u021bi<\/strong><\/p>\n<p>Panelul cuprinde peste 95 de metaboli\u021bi, organiza\u021bi \u00een mai multe categorii.<\/p>\n<p><strong>1. Metaboli\u021bi asocia\u021bi activit\u0103\u021bii microbiene<\/strong><\/p>\n<p>Exemple:<\/p>\n<ul>\n<li>acid arabinozic;<\/li>\n<li>acid tartric;<\/li>\n<li>acid 3-(3-hidroxifenil)-3-hidroxipropionic (HPHPA);<\/li>\n<li>4-cresol;<\/li>\n<li>acid indolacetic.<\/li>\n<\/ul>\n<p>Ace\u0219ti compu\u0219i pot avea origini metabolice diferite, inclusiv microbiene sau alimentare. Modific\u0103rile lor nu permit, \u00een mod independent, diagnosticul disbiozei intestinale sau identificarea unei infec\u021bii fungice.<\/p>\n<p><strong>2. Metabolism energetic<\/strong><\/p>\n<p>Exemple:<\/p>\n<ul>\n<li>acid succinic;<\/li>\n<li>acid fumaric;<\/li>\n<li>acid malic;<\/li>\n<li>acid \u03b1-cetoglutaric;<\/li>\n<li>acid citric;<\/li>\n<li>acid piruvic.<\/li>\n<\/ul>\n<p>Ace\u0219ti metaboli\u021bi particip\u0103 la procesele de producere a energiei celulare. Modific\u0103rile concentra\u021biilor urinare pot ap\u0103rea \u00een contexte metabolice diferite \u0219i nu confirm\u0103 singure existen\u021ba unei disfunc\u021bii mitocondriale.<\/p>\n<p><strong>3. Metabolismul vitaminelor \u0219i al cofactorilor<\/strong><\/p>\n<p>Exemple:<\/p>\n<ul>\n<li>acid metilmalonic (MMA);<\/li>\n<li>acid formiminoglutamic (FIGLU);<\/li>\n<li>acid xanturenic;<\/li>\n<li>acid etilmalonic.<\/li>\n<\/ul>\n<p>Anumi\u021bi metaboli\u021bi pot furniza indicii privind utilizarea vitaminelor \u0219i func\u021bionarea unor reac\u021bii dependente de cofactori.<\/p>\n<p>De exemplu, cre\u0219terea acidului metilmalonic poate ap\u0103rea \u00een deficitul de vitamina B12, dar \u0219i \u00een alte situa\u021bii clinice, inclusiv \u00een unele tulbur\u0103ri metabolice ereditare.<\/p>\n<p><strong>4. Metaboli\u021bi asocia\u021bi neurotransmi\u021b\u0103torilor<\/strong><\/p>\n<p>Exemple:<\/p>\n<ul>\n<li>acid homovanilic (HVA);<\/li>\n<li>acid vanilmandelic (VMA);<\/li>\n<li>acid 5-hidroxiindolacetic (5-HIAA);<\/li>\n<li>acid kinurenic;<\/li>\n<li>acid chinolinic.<\/li>\n<\/ul>\n<p>Ace\u0219ti compu\u0219i sunt implica\u021bi \u00een metabolismul catecolaminelor, serotoninei sau triptofanului. Determinarea lor urinar\u0103 nu permite evaluarea direct\u0103 a concentra\u021biilor neurotransmi\u021b\u0103torilor din sistemul nervos central.<\/p>\n<p><strong>5. Metabolismul oxala\u021bilor<\/strong><\/p>\n<p>Exemple:<\/p>\n<ul>\n<li>acid oxalic;<\/li>\n<li>acid glicolic;<\/li>\n<li>acid gliceric.<\/li>\n<\/ul>\n<p>Ace\u0219ti metaboli\u021bi pot fi relevan\u021bi \u00een investigarea unor tulbur\u0103ri ale metabolismului oxala\u021bilor. \u00cen cazul suspiciunii unei afec\u021biuni specifice, sunt necesare investiga\u021bii dedicate.<\/p>\n<p><strong>6. Metaboli\u021bi asocia\u021bi unor tulbur\u0103ri metabolice ereditare<\/strong><\/p>\n<p>Exemple:<\/p>\n<ul>\n<li>acid 3-hidroxipropionic;<\/li>\n<li>tiglilglicin\u0103;<\/li>\n<li>succinilaceton\u0103;<\/li>\n<li>izovalerilglicin\u0103.<\/li>\n<\/ul>\n<p>Anumite modific\u0103ri ale acestor metaboli\u021bi pot orienta suspiciunea unor erori \u00eenn\u0103scute de metabolism, care necesit\u0103 evaluare de specialitate \u0219i teste de confirmare.<\/p>\n<p>Lista complet\u0103 a parametrilor determina\u021bi \u0219i intervalele de referin\u021b\u0103 sunt prezentate \u00een raportul de analiz\u0103.<\/p>\n<p><strong>C\u00e2nd poate fi recomandat\u0103 analiza?<\/strong><\/p>\n<p>Analiza acizilor organici urinari are o utilitate clinic\u0103 bine documentat\u0103 \u00een investigarea anumitor boli metabolice ereditare, \u00een special a tulbur\u0103rilor metabolismului aminoacizilor \u0219i al acizilor organici.<\/p>\n<p>\u00cen func\u021bie de contextul clinic \u0219i de caracteristicile metodei utilizate, determinarea acizilor organici poate fi indicat\u0103 \u00een situa\u021bii precum:<\/p>\n<ul>\n<li>suspiciunea unei boli metabolice ereditare;<\/li>\n<li>modific\u0103ri metabolice inexplicabile, inclusiv acidoz\u0103 metabolic\u0103;<\/li>\n<li>episoade recurente de hipoglicemie, cetoz\u0103 sau decompensare metabolic\u0103;<\/li>\n<li>manifest\u0103ri neurologice sau \u00eent\u00e2rzieri de dezvoltare care ridic\u0103 suspiciunea unei afec\u021biuni metabolice;<\/li>\n<li>rezultate anormale ale screeningului neonatal, atunci c\u00e2nd sunt necesare investiga\u021bii suplimentare;<\/li>\n<li>modific\u0103ri biochimice care necesit\u0103 clarificare prin teste metabolice specifice.<\/li>\n<\/ul>\n<p>Profilul extins poate fi utilizat \u0219i ca investiga\u021bie metabolic\u0103 complementar\u0103, la recomandarea medicului. Totu\u0219i, utilitatea sa pentru evaluarea oboselii cronice, disbiozei intestinale, tulbur\u0103rilor de dispozi\u021bie sau a unor dezechilibre nutri\u021bionale nespecifice nu este suficient validat\u0103 pentru utilizarea ca test diagnostic de rutin\u0103.<\/p>\n<p>\u00cen cazul suspiciunii unei boli metabolice ereditare, medicul trebuie s\u0103 stabileasc\u0103 dac\u0103 panelul utilizat este adecvat scopului diagnostic sau dac\u0103 este necesar\u0103 o analiz\u0103 specializat\u0103 a acizilor organici urinari.<\/p>\n<p><strong>Metoda de analiz\u0103<\/strong><\/p>\n<p>LC-MS\/MS<\/p>\n<p><strong>Interpretarea rezultatelor<\/strong><\/p>\n<p>Interpretarea profilului se bazeaz\u0103 pe analiza concentra\u021biilor individuale \u0219i a asocierilor dintre metaboli\u021bii modifica\u021bi.<\/p>\n<p>Rezultatele pot fi influen\u021bate de alimenta\u021bie, suplimente, medica\u021bie, func\u021bia renal\u0103, starea metabolic\u0103 \u0219i activitatea unor microorganisme.<\/p>\n<p>O valoare crescut\u0103 sau sc\u0103zut\u0103 nu indic\u0103 automat o afec\u021biune. \u00cen func\u021bie de modific\u0103rile identificate, medicul poate recomanda investiga\u021bii biochimice, microbiologice sau genetice suplimentare.<\/p>\n<p>Un rezultat normal nu exclude toate tulbur\u0103rile metabolice, deoarece eliminarea unor metaboli\u021bi poate varia \u00een func\u021bie de starea clinic\u0103 \u0219i de momentul recolt\u0103rii.<\/p>\n<p><strong>Preg\u0103tirea pacientului \u0219i recoltarea<\/strong><\/p>\n<p>Tip prob\u0103: urin\u0103 spontan\u0103, preferabil prima urin\u0103 de diminea\u021b\u0103, din jetul mijlociu.<\/p>\n<p>Volum necesar: aproximativ 10 mL.<\/p>\n<p>Pentru preg\u0103tirea recolt\u0103rii se recomand\u0103:<\/p>\n<ul>\n<li>cu 48 de ore \u00eenainte, evitarea consumului de mere, struguri, pere, stafide, meri\u0219oare \u0219i vin;<\/li>\n<li>continuarea medica\u021biei prescrise; aceasta nu trebuie \u00eentrerupt\u0103 f\u0103r\u0103 recomandarea medicului.<\/li>\n<\/ul>\n<p><strong>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/strong><\/p>\n<p>Profilul acizilor organici urinari nu reprezint\u0103 un test universal pentru diagnosticarea tulbur\u0103rilor metabolice, digestive, neurologice sau nutri\u021bionale.<\/p>\n<p>\u00cen particular:<\/p>\n<ul>\n<li>nu stabile\u0219te singur diagnosticul disbiozei intestinale;<\/li>\n<li>nu permite identificarea direct\u0103 a microorganismelor intestinale;<\/li>\n<li>nu confirm\u0103 independent un deficit de vitamine;<\/li>\n<li>nu demonstreaz\u0103 singur existen\u021ba unei disfunc\u021bii mitocondriale;<\/li>\n<li>nu m\u0103soar\u0103 direct activitatea neurotransmi\u021b\u0103torilor cerebrali;<\/li>\n<li>nu \u00eenlocuie\u0219te investiga\u021biile specializate necesare pentru confirmarea bolilor metabolice ereditare.<\/li>\n<\/ul>\n<p>Rezultatele trebuie corelate cu manifest\u0103rile clinice, cu istoricul medical \u0219i cu alte investiga\u021bii, sub \u00eendrumarea medicului specialist.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Profilul acizilor organici urinari este o analiz\u0103 complex\u0103 care determin\u0103 peste 95 de metaboli\u021bi implica\u021bi \u00een diferite procese biochimice, precum metabolismul aminoacizilor, producerea energiei celulare, utilizarea vitaminelor \u0219i metabolismul unor compu\u0219i de origine microbian\u0103. Testul poate furniza informa\u021bii complementare despre anumite c\u0103i metabolice \u0219i poate orienta investiga\u021bii suplimentare, \u00een func\u021bie de contextul clinic. Rezultatele necesit\u0103 interpretare medical\u0103, deoarece modific\u0103rile individuale ale metaboli\u021bilor nu stabilesc, \u00een mod independent, un diagnostic.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,3169,5020,2876],"product_tag":[],"class_list":["post-144468","product","type-product","status-publish","product_cat-analize","product_cat-biochimie","product_cat-biochimie-urinara","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Profilul acizilor organici urinari este o analiz\u0103 complex\u0103 care determin\u0103 peste 95 de metaboli\u021bi implica\u021bi \u00een diferite procese biochimice, precum metabolismul aminoacizilor, producerea energiei celulare, utilizarea vitaminelor \u0219i metabolismul unor compu\u0219i de origine microbian\u0103. Testul poate furniza informa\u021bii complementare despre anumite c\u0103i metabolice \u0219i poate orienta investiga\u021bii suplimentare, \u00een func\u021bie de contextul clinic. 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Testul poate furniza informa\u021bii complementare despre anumite c\u0103i metabolice \u0219i poate orienta investiga\u021bii suplimentare, \u00een func\u021bie de contextul clinic. 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Testul poate furniza informa\u021bii complementare despre anumite c\u0103i metabolice \u0219i poate orienta investiga\u021bii suplimentare, \u00een func\u021bie de contextul clinic. Rezultatele necesit\u0103 interpretare medical\u0103, deoarece modific\u0103rile individuale ale metaboli\u021bilor nu stabilesc, \u00een mod independent, un diagnostic.\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie\\\/acizi-organici-in-urina\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro#listItem\",\"position\":1,\"name\":\"Prima pagin\\u0103\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"name\":\"Analize Medicale\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"position\":2,\"name\":\"Analize Medicale\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"name\":\"Analize\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro#listItem\",\"name\":\"Prima pagin\\u0103\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"position\":3,\"name\":\"Analize\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"name\":\"Serviciu laborator\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-medicale\\\/#listItem\",\"name\":\"Analize Medicale\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"position\":4,\"name\":\"Serviciu laborator\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie\\\/#listItem\",\"name\":\"Biochimie\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize\\\/#listItem\",\"name\":\"Analize\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie\\\/#listItem\",\"position\":5,\"name\":\"Biochimie\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie-urinara\\\/#listItem\",\"name\":\"Biochimie urinar\\u0103\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-serviciu-laborator\\\/#listItem\",\"name\":\"Serviciu laborator\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie-urinara\\\/#listItem\",\"position\":6,\"name\":\"Biochimie urinar\\u0103\",\"item\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie-urinara\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie\\\/acizi-organici-in-urina\\\/#listItem\",\"name\":\"Acizi organici \\u00een urin\\u0103\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie\\\/#listItem\",\"name\":\"Biochimie\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie\\\/acizi-organici-in-urina\\\/#listItem\",\"position\":7,\"name\":\"Acizi organici \\u00een urin\\u0103\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/analize-biochimie-urinara\\\/#listItem\",\"name\":\"Biochimie urinar\\u0103\"}}]},{\"@type\":\"MedicalOrganization\",\"@id\":\"https:\\\/\\\/www.clinica-sante.com\\\/ro\\\/#organization\",\"name\":\"Clinica Sante - 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