{"id":144443,"date":"2026-11-02T10:07:22","date_gmt":"2026-11-02T08:07:22","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize\/anticorpi-anti-receptor-de-folat-alfa-frat\/"},"modified":"2026-11-03T16:36:52","modified_gmt":"2026-11-03T14:36:52","slug":"anticorpi-anti-receptor-de-folat-alfa-frat","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-boli-autoimune-imunologie\/anticorpi-anti-receptor-de-folat-alfa-frat\/","title":{"rendered":"Anticorpi anti-receptor de folat alfa \/ FRAT"},"content":{"rendered":"<p><strong>1. Descriere scurt\u0103<\/strong><\/p>\n<p>Test imunologic specializat pentru determinarea autoanticorpilor \u00eendrepta\u021bi \u00eempotriva receptorului de folat alfa, incluz\u00e2nd <strong>autoanticorpi blocan\u021bi<\/strong> \u0219i <strong>autoanticorpi de legare<\/strong>.<\/p>\n<p>Testarea poate contribui la evaluarea unor situa\u021bii \u00een care autoanticorpii anti-receptor de folat pot interfera cu transportul \u0219i disponibilitatea folatului la nivel celular \u0219i, \u00een anumite contexte, la nivelul sistemului nervos central.<\/p>\n<p><strong>2. Parametrii analiza\u021bi<\/strong><\/p>\n<p>Testul determin\u0103:<\/p>\n<ul>\n<li>autoanticorpi blocan\u021bi \u00eempotriva receptorului de folat;<\/li>\n<li>autoanticorpi de legare \u00eempotriva receptorului de folat.<\/li>\n<\/ul>\n<p>Rezultatul este interpretat conform criteriilor laboratorului de referin\u021b\u0103 care efectueaz\u0103 analiza.<\/p>\n<p><strong>3. Descriere general\u0103<\/strong><\/p>\n<p>Receptorul de folat alfa (FR\u03b1) este o protein\u0103 implicat\u0103 \u00een transportul folatului c\u0103tre celule. Folatul are un rol esen\u021bial \u00een sinteza ADN, diviziunea celular\u0103 \u0219i metabolismul cu un singur carbon.<\/p>\n<p>Autoanticorpii anti-receptor de folat pot interac\u021biona cu receptorul de folat prin mecanisme diferite. <strong>Autoanticorpii blocan\u021bi<\/strong> pot interfera cu func\u021bia receptorului, \u00een timp ce <strong>autoanticorpii de legare<\/strong> se leag\u0103 de receptor f\u0103r\u0103 ca efectul lor func\u021bional s\u0103 fie neap\u0103rat echivalent cu cel al anticorpilor blocan\u021bi.<\/p>\n<p>Prezen\u021ba acestor autoanticorpi poate fi investigat\u0103 \u00een contexte clinice selectate \u00een care exist\u0103 suspiciunea unei perturb\u0103ri a transportului folatului mediat de receptor.<\/p>\n<p>Testul este efectuat \u00eentr-un <strong>laborator extern de referin\u021b\u0103 specializat \u00een analiza FRAT<\/strong>.<\/p>\n<p><strong>4. Afec\u021biuni sau simptome asociate<\/strong><\/p>\n<p>Testarea poate fi luat\u0103 \u00een considerare, \u00een func\u021bie de contextul clinic, \u00een evaluarea unor situa\u021bii asociate cu:<\/p>\n<ul>\n<li>suspiciune de perturbare a transportului folatului;<\/li>\n<li>manifest\u0103ri neurologice sau neuropsihiatrice pentru care exist\u0103 indica\u021bie clinic\u0103 de investigare a metabolismului folatului;<\/li>\n<li>tulbur\u0103ri de dezvoltare neurologic\u0103, \u00een special \u00een contexte pediatrice selectate;<\/li>\n<li>suspiciune de deficit func\u021bional al folatului la nivelul sistemului nervos central, \u00een ciuda unor valori periferice care nu explic\u0103 tabloul clinic;<\/li>\n<li>situa\u021bii \u00een care investiga\u021biile metabolice sau neurologice sugereaz\u0103 necesitatea evalu\u0103rii mecanismelor de transport al folatului.<\/li>\n<\/ul>\n<p>Prezen\u021ba autoanticorpilor nu stabile\u0219te singur\u0103 diagnosticul unei afec\u021biuni \u0219i trebuie corelat\u0103 cu tabloul clinic \u0219i cu investiga\u021biile relevante.<\/p>\n<p><strong>5. Cui se adreseaz\u0103<\/strong><\/p>\n<p>Testul poate fi recomandat, la indica\u021bia medicului, persoanelor la care exist\u0103:<\/p>\n<ul>\n<li>suspiciune clinic\u0103 de afectare a transportului folatului;<\/li>\n<li>manifest\u0103ri neurologice sau neuropsihiatrice care justific\u0103 investiga\u021bii metabolice suplimentare;<\/li>\n<li>suspiciune de tulburare a metabolismului folatului care nu este explicat\u0103 prin evaluarea uzual\u0103 a folatului;<\/li>\n<li>indica\u021bie pentru evaluarea autoimunit\u0103\u021bii \u00eendreptate \u00eempotriva receptorului de folat.<\/li>\n<\/ul>\n<p>\u00cen special \u00een cazul copiilor, rezultatul trebuie interpretat de medicul care urm\u0103re\u0219te pacientul, \u00eempreun\u0103 cu istoricul de dezvoltare \u0219i rezultatele celorlalte investiga\u021bii.<\/p>\n<p><strong>6. Metodologie de testare<\/strong><\/p>\n<p>Testarea se realizeaz\u0103 printr-o <strong>imunoanaliz\u0103 FRAT specializat\u0103<\/strong>, efectuat\u0103 \u00eentr-un laborator extern de referin\u021b\u0103.<\/p>\n<p>Analiza urm\u0103re\u0219te identificarea \u0219i caracterizarea autoanticorpilor anti-receptor de folat prin determinarea componentelor de tip blocant \u0219i de legare.<\/p>\n<p><strong>7. Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/strong><\/p>\n<p>Testarea poate contribui la:<\/p>\n<ul>\n<li>identificarea autoanticorpilor anti-receptor de folat;<\/li>\n<li>diferen\u021bierea componentelor de tip blocant \u0219i de legare;<\/li>\n<li>completarea evalu\u0103rii pacien\u021bilor cu suspiciune de perturbare a transportului folatului;<\/li>\n<li>orientarea investiga\u021biilor suplimentare atunci c\u00e2nd rezultatul este pozitiv;<\/li>\n<li>integrarea rezultatelor imunologice cu evaluarea metabolismului folatului \u0219i cu datele neurologice sau clinice.<\/li>\n<\/ul>\n<p>Un rezultat pozitiv trebuie interpretat \u00een contextul clinic \u0219i nu reprezint\u0103, \u00een mod izolat, dovada unei boli specifice.<\/p>\n<p><strong>8. Particularit\u0103\u021bi \u0219i limit\u0103ri<\/strong><\/p>\n<ul>\n<li>Prezen\u021ba autoanticorpilor nu demonstreaz\u0103 \u00een mod automat existen\u021ba unei boli clinice asociate.<\/li>\n<li>Semnifica\u021bia clinic\u0103 poate depinde de tipul autoanticorpului identificat, de titrul sau valoarea acestuia \u0219i de tabloul clinic <\/li>\n<li>Rezultatele trebuie corelate cu statusul folatului \u0219i al vitaminei B12, precum \u0219i cu alte investiga\u021bii relevante, atunci c\u00e2nd sunt indicate.<\/li>\n<li>Rezultatul poate fi influen\u021bat de particularit\u0103\u021bile metodologice ale laboratorului de referin\u021b\u0103 \u0219i de criteriile de interpretare utilizate.<\/li>\n<li>Un rezultat negativ nu exclude toate cauzele posibile ale unei tulbur\u0103ri de transport sau metabolism al folatului.<\/li>\n<li>\u00centreruperea acidului folinic\/5-MTHF \u00eenaintea recolt\u0103rii se realizeaz\u0103 <strong>numai atunci c\u00e2nd este clinic adecvat \u0219i conform recomand\u0103rii medicului<\/strong>.<\/li>\n<li>Testul nu trebuie utilizat ca investiga\u021bie izolat\u0103 pentru diagnosticarea unei afec\u021biuni neurologice, de neurodezvoltare sau autoimune.<\/li>\n<\/ul>\n<p><strong>9. Tip prob\u0103<\/strong><\/p>\n<ul>\n<li>Ser<\/li>\n<\/ul>\n<p><strong>10. Recoltare \u0219i condi\u021bii<\/strong><\/p>\n<ul>\n<li>Recoltarea se efectueaz\u0103 \u00een tub cu gel separator pentru ser.<\/li>\n<li>Timp de execu\u021bie: 50 de zile lucr\u0103toare.<\/li>\n<\/ul>\n<p><strong>11. Denumiri alternative<\/strong><\/p>\n<ul>\n<li>Folate Receptor Autoantibody Test<\/li>\n<li>FRAT<\/li>\n<li>Folate Receptor Antibody Test<\/li>\n<li>Autoanticorpi anti-receptor de folat<\/li>\n<li>Anticorpi anti-receptor de folat<\/li>\n<li>Folate Receptor Alpha Autoantibodies<\/li>\n<li>Folate Receptor Blocking Antibodies<\/li>\n<li>Folate Receptor Binding Antibodies<\/li>\n<li>FR\u03b1 autoantibodies<\/li>\n<\/ul>\n<p><strong>12. Analize asociate recomandate<\/strong><\/p>\n<p>\u00cen func\u021bie de contextul clinic, testul poate fi corelat cu:<\/p>\n<ul>\n<li>folat seric;<\/li>\n<li>vitamina B12;<\/li>\n<li>homocistein\u0103;<\/li>\n<li>acid metilmalonic;<\/li>\n<li>hemogram\u0103 complet\u0103;<\/li>\n<li>profil de vitamine din grupul B;<\/li>\n<li>profil metabolic general;<\/li>\n<li>func\u021bie renal\u0103 \u0219i hepatic\u0103;<\/li>\n<li>investiga\u021bii neurologice, atunci c\u00e2nd sunt indicate;<\/li>\n<li>evaluare genetic\u0103\/metabolic\u0103 \u00een cazurile cu suspiciune de tulburare ereditar\u0103 a metabolismului sau transportului folatului;<\/li>\n<li>alte investiga\u021bii imunologice, \u00een func\u021bie de suspiciunea clinic\u0103.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Analiza <strong>Anticorpi anti-receptor de folat alfa \/ FRAT<\/strong> identific\u0103 dou\u0103 tipuri de autoanticorpi \u00eendrepta\u021bi \u00eempotriva receptorului de folat alfa: anticorpi blocan\u021bi \u0219i anticorpi de legare. Poate fi recomandat\u0103 de medic \u00een situa\u021bii selectate, c\u00e2nd exist\u0103 suspiciunea unei perturb\u0103ri a transportului folatului, inclusiv \u00een evaluarea unor manifest\u0103ri neurologice sau tulbur\u0103ri de dezvoltare.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,4988,3180,2876],"product_tag":[],"class_list":["post-144443","product","type-product","status-publish","product_cat-analize","product_cat-boli-autoimune-imunologie","product_cat-imunologie","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Analiza Anticorpi anti-receptor de folat alfa \/ FRAT identific\u0103 dou\u0103 tipuri de autoanticorpi \u00eendrepta\u021bi \u00eempotriva receptorului de folat alfa: anticorpi blocan\u021bi \u0219i anticorpi de legare. Poate fi recomandat\u0103 de medic \u00een situa\u021bii selectate, c\u00e2nd exist\u0103 suspiciunea unei perturb\u0103ri a transportului folatului, inclusiv \u00een evaluarea unor manifest\u0103ri neurologice sau tulbur\u0103ri de dezvoltare.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.clinica-sante.com\/ro\/analize-boli-autoimune-imunologie\/anticorpi-anti-receptor-de-folat-alfa-frat\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinica Sante - Laborator de Analize Medicale - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Anticorpi anti-receptor de folat alfa \/ FRAT - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:description\" content=\"Analiza Anticorpi anti-receptor de folat alfa \/ FRAT identific\u0103 dou\u0103 tipuri de autoanticorpi \u00eendrepta\u021bi \u00eempotriva receptorului de folat alfa: anticorpi blocan\u021bi \u0219i anticorpi de legare. 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