{"id":141363,"date":"2026-10-21T16:06:00","date_gmt":"2026-10-21T13:06:00","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize\/pan-cancer-comprehensive\/"},"modified":"2026-10-21T16:06:00","modified_gmt":"2026-10-21T13:06:00","slug":"pan-cancer-comprehensive","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-genetica\/pan-cancer-comprehensive\/","title":{"rendered":"Pan Cancer Comprehensive"},"content":{"rendered":"<p><span style=\"color: #252525\">Cancerul este o boal\u0103 genomic\u0103 heterogen\u0103, \u00een care acumularea de modific\u0103ri genetice poate determina activarea oncogenelor, inactivarea genelor supresoare tumorale \u0219i alterarea mecanismelor de reparare a ADN-ului.<\/span><\/p>\n<p><span style=\"color: #252525\">PAN-CANCER COMPREHENSIVE investigheaz\u0103 simultan mai multe clase de alter\u0103ri moleculare \u0219i mai multe c\u0103i implicate \u00een oncogenez\u0103:<\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">calea<\/span><span style=\"color: #252525\"> MAPK\/RAS\/RAF, <\/span><\/li>\n<li><span style=\"color: #252525\">calea PI3K\/AKT\/mTOR, <\/span><\/li>\n<li><span style=\"color: #252525\">receptori tirozin-kinazici,<\/span><\/li>\n<li><span style=\"color: #252525\">controlul ciclului celular,<\/span><\/li>\n<li><span style=\"color: #252525\">gene supresoare tumorale,<\/span><\/li>\n<li><span style=\"color: #252525\">mecanisme de reparare a ADN-ului,<\/span><\/li>\n<li><span style=\"color: #252525\">c\u0103i implicate \u00een instabilitatea genomic\u0103,<\/span><\/li>\n<li><span style=\"color: #252525\">mecanisme de proliferare \u0219i diferen\u021biere celular\u0103,<\/span><\/li>\n<li><span style=\"color: #252525\">fuziuni oncogenice \u0219i rearanj\u0103ri genomice,<\/span><\/li>\n<li><span style=\"color: #252525\">amplific\u0103ri \u0219i dele\u021bii genice.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #262626\"><strong>Gene analizate<\/strong><\/span><\/p>\n<p><span style=\"color: #262626\">Testul utilizeaz\u0103 o abordare multicomponent\u0103:<\/span><\/p>\n<p><span style=\"color: #262626\"><strong>1. Hotspot genes<\/strong><\/span><span style=\"color: #262626\"> \u2013 analiz\u0103 focalizat\u0103 a regiunilor hotspot pentru identificarea variantelor recurente oncogenice:<\/span><\/p>\n<p><span style=\"color: #262626\">AKT1, AKT2, AKT3, ALK, AR, ARAF, AXL, BRAF, BTK, CBL, CCND1, CDK4, CDK6, CHEK2, CSF1R, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3F3A, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KDR, KIT, KRAS, MAP2K1, MAP2K2, MAP2K4, MAPK1, MAX, MDM4, MED12, MET, MTOR, MYC, MYCN, MYD88, NFE2L2, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PTPN11, RAC1, RAF1, RET, RHEB, RHOA, ROS1, SF3B1, SMO, SPOP, SRC, STAT3, TERT, U2AF1, XPO1.<\/span><\/p>\n<p><span style=\"color: #262626\"><strong>2. Full-length genes<\/strong><\/span><span style=\"color: #262626\"> \u2013 secven\u021biere extins\u0103 a genelor:<\/span><\/p>\n<p><span style=\"color: #262626\">ARID1A, ATM, ATR, ATRX, BAP1, BRCA1, BRCA2, CDK12, CDKN1B, CDKN2A, CDKN2B, CREBBP, ESR1, FANCA, FANCD2, FANCI, FBXW7, MLH1, MRE11, MSH2, MSH6, NBN, NF1, NF2, NOTCH1, NOTCH2, NOTCH3, PALB2, PMS2, POLE, PTEN, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RB1, RNF43, SETD2, SLX4, SMARCA4, SMARCB1, STK11, TSC1, TSC2, TP53.<\/span><\/p>\n<p><span style=\"color: #262626\"><strong>3. Copy number genes<\/strong><\/span><span style=\"color: #262626\"> \u2013 analiza alter\u0103rilor num\u0103rului de copii ale unor gene relevante oncologic, incluz\u00e2nd, \u00eentre altele:<\/span><\/p>\n<p><span style=\"color: #262626\">CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, EGFR, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, FGFR4, IGF1R, MDM2, MDM4, MET, MYC, MYCL, MYCN, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PPARG, RICTOR, TERT.<\/span><\/p>\n<p><span style=\"color: #262626\"><strong>4. Gene fusions \u2013 fuziuni inter- \u0219i intragenice<\/strong><\/span><\/p>\n<p><span style=\"color: #262626\">Sunt evaluate fuziuni relevante care implic\u0103 gene precum:<\/span><\/p>\n<p><span style=\"color: #262626\">ALK, AR, AXL, BRAF, BRCA1, BRCA2, EGFR, ERBB2, ERG, ESR1, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, IGF1R, JAK2, KIT, KRAS, MDM2, MDM4, MET, MYB, MYBL1, MYC, MYCL, NRG1, NTRK1, NTRK2, NTRK3, NOTCH1, NOTCH4, PDGFRA, PDGFRB, PPARG, PRKACA, PRKACB, RAF1, RELA, RET, ROS1, RSPO2, RSPO3 \u0219i NUTM1.<\/span><\/p>\n<p><span style=\"color: #252525\"><strong>Tipuri de alter\u0103ri genetice investigate<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">SNV \u2013 variante nucleotidice simple,<\/span><\/li>\n<li><span style=\"color: #252525\">INDEL \u2013 inser\u021bii \u0219i dele\u021bii,<\/span><\/li>\n<li><span style=\"color: #252525\">muta\u021bii hotspot, <\/span><\/li>\n<li><span style=\"color: #252525\">variante \u00een gene analizate full-length, <\/span><\/li>\n<li><span style=\"color: #252525\">CNV \u2013 amplific\u0103ri \u0219i dele\u021bii,<\/span><\/li>\n<li><span style=\"color: #252525\">fuziuni genice intergenice, <\/span><\/li>\n<li><span style=\"color: #252525\">fuziuni\/rearanj\u0103ri intragenice, <\/span><span style=\"color: #252525\">\u00een func\u021bie de designul assay-ului.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\">Aceast\u0103 combina\u021bie permite o caracterizare molecular\u0103 mai larg\u0103 dec\u00e2t analiza exclusiv\u0103 a muta\u021biilor hotspot.<\/span><\/p>\n<p><span style=\"color: #252525\"><strong>Cui se adreseaz\u0103<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">pacien\u021bilor cu tumori solide confirmate histopatologic,<\/span><\/li>\n<li><span style=\"color: #252525\">pacien\u021bilor cu boal\u0103 avansat\u0103 sau metastatic\u0103,<\/span><\/li>\n<li><span style=\"color: #252525\">cazurilor \u00een care este necesar\u0103 caracterizarea molecular\u0103 a tumorii,<\/span><\/li>\n<li><span style=\"color: #252525\">pacien\u021bilor pentru care se ia \u00een considerare terapia \u021bintit\u0103,<\/span><\/li>\n<li><span style=\"color: #252525\">cazurilor cu progresie sau rezisten\u021b\u0103 la tratament, atunci c\u00e2nd profilarea molecular\u0103 este indicat\u0103,<\/span><\/li>\n<li><span style=\"color: #252525\">tumorilor cu profil molecular neclar dup\u0103 test\u0103ri \u021bintite anterioare,<\/span><\/li>\n<li><span style=\"color: #252525\">pacien\u021bilor evalua\u021bi \u00een cadrul programelor de medicin\u0103 oncologic\u0103 de precizie,<\/span><\/li>\n<li><span style=\"color: #252525\">cazurilor \u00een care se urm\u0103re\u0219te identificarea unor biomarkeri pentru studii clinice.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\"><strong>Metodologie de testare<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\"><strong>secven\u021biere NGS (Next Generation Sequencing),<\/strong><\/span> <\/li>\n<li><span style=\"color: #252525\">analiz\u0103 molecular\u0103 a ADN-ului tumoral \u0219i, pentru componenta de fuziuni, a ARN-ului atunci c\u00e2nd este prev\u0103zut de metodologia assay-ului,<\/span><\/li>\n<li><span style=\"color: #252525\">analiz\u0103 hotspot,<\/span><\/li>\n<li><span style=\"color: #252525\">secven\u021biere full-length pentru genele incluse \u00een aceast\u0103 categorie,<\/span><\/li>\n<li><span style=\"color: #252525\">analiz\u0103 a varia\u021biilor num\u0103rului de copii (<\/span><span style=\"color: #252525\">CNV<\/span><span style=\"color: #252525\">),<\/span><\/li>\n<li><span style=\"color: #252525\">analiz\u0103 a fuziunilor genice inter- \u0219i intragenice,<\/span><\/li>\n<li><span style=\"color: #252525\">analiz\u0103 bioinformatic\u0103 avansat\u0103,<\/span><\/li>\n<li><span style=\"color: #252525\">interpretarea variantelor \u00een context oncologic.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\"><strong>Beneficii \u0219i importan\u021b\u0103 clinic\u0103<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">ofer\u0103 o <\/span><span style=\"color: #252525\"><strong>caracterizare molecular\u0103 extins\u0103 a tumorii,<\/strong><\/span> <\/li>\n<li><span style=\"color: #252525\">identific\u0103 alter\u0103ri genetice poten\u021bial relevante pentru tratamentul \u021bintit,<\/span><\/li>\n<li><span style=\"color: #252525\">permite investigarea simultan\u0103 a mai multor mecanisme moleculare,<\/span><\/li>\n<li><span style=\"color: #252525\">poate identifica alter\u0103ri care nu sunt eviden\u021biate prin testarea unei singure gene,<\/span><\/li>\n<li><span style=\"color: #252525\">contribuie la selec\u021bia biomarkerilor relevan\u021bi pentru medicina de precizie,<\/span><\/li>\n<li><span style=\"color: #252525\">poate sus\u021bine alegerea unor terapii \u021bintite atunci c\u00e2nd alterarea identificat\u0103 are relevan\u021b\u0103 clinic\u0103,<\/span><\/li>\n<li><span style=\"color: #252525\">poate contribui la identificarea pacien\u021bilor eligibili pentru anumite studii clinice,<\/span><\/li>\n<li><span style=\"color: #252525\">permite o utilizare mai eficient\u0103 a materialului tumoral disponibil.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\"><strong>Particularit\u0103\u021bi \u0219i limit\u0103ri<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">rezultatul este destinat <\/span><span style=\"color: #252525\">caracteriz\u0103rii somatice a tumorii<\/span><span style=\"color: #252525\"> \u0219i trebuie interpretat \u00een context clinic, histopatologic \u0219i oncologic,<\/span><\/li>\n<li><span style=\"color: #252525\">identificarea unei variante nu \u00eenseamn\u0103 automat c\u0103 aceasta este responsabil\u0103 de dezvoltarea tumorii sau c\u0103 exist\u0103 o terapie aprobat\u0103 pentru respectiva alterare,<\/span><\/li>\n<li><span style=\"color: #252525\">relevan\u021ba clinic\u0103 a unei variante poate depinde de tipul \u0219i localizarea tumorii,<\/span><\/li>\n<li><span style=\"color: #252525\">pot fi identificate variante cu semnifica\u021bie clinic\u0103 incert\u0103<\/span><span style=\"color: #252525\"> (VUS)<\/span><span style=\"color: #252525\">,<\/span><\/li>\n<li><span style=\"color: #252525\">un rezultat negativ nu exclude existen\u021ba unor alter\u0103ri genomice care nu sunt acoperite de assay,<\/span><\/li>\n<li><span style=\"color: #252525\">calitatea \u0219i cantitatea materialului tumoral pot influen\u021ba performan\u021ba analizei,<\/span><\/li>\n<li><span style=\"color: #252525\">heterogenitatea tumoral\u0103 \u0219i procentul de celule tumorale pot influen\u021ba detectarea variantelor,<\/span><\/li>\n<li><span style=\"color: #252525\">anumite alter\u0103ri structurale complexe pot necesita metode complementare,<\/span><\/li>\n<li><span style=\"color: #252525\">rezultatele trebuie interpretate \u00eempreun\u0103 cu datele histopatologice, imunohistochimice \u0219i clinice.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\"><strong>Tip de prob\u0103<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\"><strong>\u021besut tumoral FFPE<\/strong><\/span><span style=\"color: #252525\"> (bloc de parafin\u0103),<\/span><\/li>\n<li><span style=\"color: #252525\">pentru analiza fuziunilor, poate fi necesar material adecvat pentru extrac\u021bia ARN-ului.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\"><strong>Recoltare \u0219i condi\u021bii<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">se utilizeaz\u0103 material tumoral fixat \u00een formalin\u0103 \u0219i inclus \u00een parafin\u0103 <\/span><span style=\"color: #252525\">(FFPE);<\/span><\/li>\n<li><span style=\"color: #252525\">este recomandat\u0103 evaluarea prealabil\u0103 a materialului de c\u0103tre anatomopatolog;<\/span><\/li>\n<li><span style=\"color: #252525\">proba trebuie s\u0103 con\u021bin\u0103 o propor\u021bie tumoral\u0103 adecvat\u0103 pentru analiza molecular\u0103;<\/span><\/li>\n<li><span style=\"color: #252525\">blocul sau sec\u021biunile trebuie s\u0103 fie \u00eenso\u021bite de documentele patologice relevante;<\/span><\/li>\n<li><span style=\"color: #252525\">pentru analiza ARN \u0219i a fuziunilor, integritatea materialului poate fi determinant\u0103;<\/span><\/li>\n<li><span style=\"color: #252525\">nu necesit\u0103 post alimentar.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\"><strong>Denumiri alternative<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">Pan-Cancer Comprehensive Assay<\/span><\/li>\n<li><span style=\"color: #252525\">Comprehensive Cancer NGS Panel<\/span><\/li>\n<li><span style=\"color: #252525\">Comprehensive Solid Tumor NGS Panel<\/span><\/li>\n<li><span style=\"color: #252525\">Panel NGS comprehensiv pentru tumori solide<\/span><\/li>\n<li><span style=\"color: #252525\">Panel molecular pan-cancer<\/span><\/li>\n<li><span style=\"color: #252525\">Profilare genomic\u0103 comprehensiv\u0103 a tumorii<\/span><\/li>\n<li><span style=\"color: #252525\">Panel somatic extins pentru cancer<\/span><\/li>\n<li><span style=\"color: #252525\">Profil molecular tumoral prin NGS<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #252525\"><strong>Analize asociate recomandate<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #252525\">examen histopatologic;<\/span><\/li>\n<li><span style=\"color: #252525\">imunohistochimie, \u00een func\u021bie de tipul tumorii;<\/span><\/li>\n<li><span style=\"color: #252525\">evaluarea markerilor moleculari specifici indica\u021biei clinice;<\/span><\/li>\n<li><span style=\"color: #252525\">MSI, dac\u0103 este indicat\u0103 clinic \u0219i nu este inclus\u0103 \u00een assay-ul utilizat;<\/span><\/li>\n<li><span style=\"color: #252525\">TMB, dac\u0103 este necesar\u0103 \u0219i nu este inclus\u0103 \u00een versiunea assay-ului;<\/span><\/li>\n<li><span style=\"color: #252525\">teste germinale pentru predispozi\u021bia ereditar\u0103 la cancer, atunci c\u00e2nd istoricul personal\/familial sugereaz\u0103 acest risc;<\/span><\/li>\n<li><span style=\"color: #252525\">consult oncologic;<\/span><\/li>\n<li><span style=\"color: #252525\">consult genetic, \u00een special atunci c\u00e2nd sunt identificate variante care pot ridica suspiciunea unei predispozi\u021bii ereditare.<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>PAN-CANCER COMPREHENSIVE este un test de <strong>profilare molecular\u0103 somatic\u0103 a tumorilor solide<\/strong>, bazat pe tehnologia NGS, conceput pentru identificarea unui spectru larg de alter\u0103ri genetice relevante clinic. Testul combin\u0103 analiza muta\u021biilor hotspot, secven\u021bierea genelor complete, identificarea modific\u0103rilor num\u0103rului de copii (<strong>CNV<\/strong>) \u0219i detectarea <strong>fuziunilor genice inter- \u0219i intragenice<\/strong>.<\/p>\n<p>Prin analiza simultan\u0103 a mai multor c\u0103i moleculare implicate \u00een oncogenez\u0103, testul contribuie la caracterizarea genomic\u0103 a tumorii \u0219i la identificarea biomarkerilor care pot fi relevan\u021bi pentru <strong>medicina oncologic\u0103 de precizie, selec\u021bia terapiilor \u021bintite \u0219i includerea \u00een studii clinice<\/strong>.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[1209,5015,5016,3165,2876],"product_tag":[],"class_list":["post-141363","product","type-product","status-publish","product_cat-analize","product_cat-genetica","product_cat-genetica-moleculara","product_cat-oncogenetica","product_cat-serviciu-laborator","first","instock","sale","virtual","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"PAN-CANCER COMPREHENSIVE este un test de profilare molecular\u0103 somatic\u0103 a tumorilor solide, bazat pe tehnologia NGS, conceput pentru identificarea unui spectru larg de alter\u0103ri genetice relevante clinic. Testul combin\u0103 analiza muta\u021biilor hotspot, secven\u021bierea genelor complete, identificarea modific\u0103rilor num\u0103rului de copii (CNV) \u0219i detectarea fuziunilor genice inter- \u0219i intragenice. Prin analiza simultan\u0103 a mai multor c\u0103i moleculare implicate \u00een oncogenez\u0103, testul contribuie la caracterizarea genomic\u0103 a tumorii \u0219i la identificarea biomarkerilor care pot fi relevan\u021bi pentru medicina oncologic\u0103 de precizie, selec\u021bia terapiilor \u021bintite \u0219i includerea \u00een studii clinice.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.clinica-sante.com\/ro\/analize-genetica\/pan-cancer-comprehensive\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinica Sante - Laborator de Analize Medicale - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Pan Cancer Comprehensive - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:description\" content=\"PAN-CANCER COMPREHENSIVE este un test de profilare molecular\u0103 somatic\u0103 a tumorilor solide, bazat pe tehnologia NGS, conceput pentru identificarea unui spectru larg de alter\u0103ri genetice relevante clinic. Testul combin\u0103 analiza muta\u021biilor hotspot, secven\u021bierea genelor complete, identificarea modific\u0103rilor num\u0103rului de copii (CNV) \u0219i detectarea fuziunilor genice inter- \u0219i intragenice. 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Prin analiza simultan\u0103 a mai multor c\u0103i moleculare implicate \u00een oncogenez\u0103, testul contribuie la caracterizarea genomic\u0103 a tumorii \u0219i la identificarea biomarkerilor care pot fi relevan\u021bi pentru medicina oncologic\u0103 de precizie, selec\u021bia terapiilor \u021bintite \u0219i includerea \u00een studii clinice."},"aioseo_meta_data":{"post_id":"141363","title":null,"description":null,"keywords":null,"keyphrases":{"focus":[],"additional":[]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"seo_analyzer_scan_date":null,"breadcrumb_settings":null,"limit_modified_date":false,"open_ai":null,"ai":null,"created":"2026-10-21 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