{"id":128743,"date":"2026-09-14T12:36:28","date_gmt":"2026-09-14T09:36:28","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/analize\/ige-specific-la-venin-de-albina-rapi-m1-fosfolipaza-a2-i208\/"},"modified":"2026-10-21T19:43:53","modified_gmt":"2026-10-21T16:43:53","slug":"ige-specific-la-venin-de-albina-rapi-m1-fosfolipaza-a2-i208","status":"publish","type":"product","link":"https:\/\/www.clinica-sante.com\/ro\/analize-alergologie\/ige-specific-la-venin-de-albina-rapi-m1-fosfolipaza-a2-i208\/","title":{"rendered":"IgE specific la venin de albin\u0103 rApi m1 &#8211; fosfolipaza A2 (i208)"},"content":{"rendered":"<h2><span style=\"color: #e67e23\">1. Descriere general\u0103<\/span><\/h2>\n<p>IgE specific la venin de albin\u0103 rApi m 1 \u2013 fosfolipaza A2 (i208) este o analiz\u0103 de s\u00e2nge care evalueaz\u0103 prezen\u021ba anticorpilor IgE specifici fa\u021b\u0103 de rApi m 1, o component\u0103 molecular\u0103 important\u0103 din veninul de albin\u0103.<\/p>\n<p>IgE sunt anticorpi produ\u0219i de sistemul imunitar. \u00cen alergiile IgE-mediate, organismul percepe \u00een mod gre\u0219it anumite substan\u021be ca fiind periculoase. Aceste substan\u021be se numesc alergeni. \u00cen cazul alergiei la venin de albin\u0103, reac\u021bia poate ap\u0103rea dup\u0103 \u00een\u021bep\u0103tur\u0103, atunci c\u00e2nd sistemul imunitar recunoa\u0219te anumite proteine din venin \u0219i declan\u0219eaz\u0103 un r\u0103spuns alergic.<\/p>\n<p>Api m 1 este fosfolipaza A2 din veninul de albin\u0103 \u0219i este considerat\u0103 una dintre componentele alergene majore ale veninului. Testarea formei recombinante, rApi m 1, face parte din diagnosticul molecular al alergiilor \u0219i poate contribui la demonstrarea unei sensibiliz\u0103ri autentice la veninul de albin\u0103.<\/p>\n<p>Analiza poate fi util\u0103 mai ales la persoanele care au prezentat reac\u021bii alergice sistemice dup\u0103 \u00een\u021bep\u0103tura de albin\u0103, de la manifest\u0103ri cutanate generalizate p\u00e2n\u0103 la reac\u021bii cu afectare respiratorie sau cardiovascular\u0103.<\/p>\n<p>Simptomele pot include:<\/p>\n<ul>\n<li>urticarie generalizat\u0103<\/li>\n<li>m\u00e2nc\u0103rimi extinse<\/li>\n<li>\u00eenro\u0219irea pielii<\/li>\n<li>umflarea buzelor, pleoapelor, fe\u021bei sau limbii<\/li>\n<li>senza\u021bie de nod \u00een g\u00e2t<\/li>\n<li>dificult\u0103\u021bi de respira\u021bie<\/li>\n<li>respira\u021bie \u0219uier\u0103toare<\/li>\n<li>ame\u021beal\u0103 sau stare de le\u0219in<\/li>\n<li>grea\u021b\u0103, v\u0103rs\u0103turi, crampe abdominale sau diaree<\/li>\n<li>sc\u0103derea tensiunii arteriale<\/li>\n<li>reac\u021bie anafilactic\u0103.<\/li>\n<\/ul>\n<p>Testarea rApi m 1 poate fi util\u0103 \u0219i atunci c\u00e2nd pacientul are rezultate pozitive la mai multe veninuri de insecte, de exemplu albin\u0103 \u0219i viespe. \u00cen aceste situa\u021bii, analiza poate ajuta medicul alergolog s\u0103 diferen\u021bieze o sensibilizare specific\u0103 la veninul de albin\u0103 de o posibil\u0103 reactivitate \u00eencruci\u0219at\u0103 sau de o sensibilizare multipl\u0103.<\/p>\n<p>Un rezultat pozitiv indic\u0103 prezen\u021ba anticorpilor IgE specifici fa\u021b\u0103 de rApi m 1, dar nu confirm\u0103 singur existen\u021ba unei alergii clinice. Unele persoane pot avea o sensibilizare detectabil\u0103 f\u0103r\u0103 s\u0103 prezinte reac\u021bii relevante la \u00een\u021bep\u0103turi. De aceea, rezultatul trebuie interpretat \u00eempreun\u0103 cu istoricul medical, tipul reac\u021biei ap\u0103rute dup\u0103 \u00een\u021bep\u0103tur\u0103, insecta suspectat\u0103, severitatea manifest\u0103rilor \u0219i recomand\u0103rile medicului alergolog.<\/p>\n<p>Analiza nu stabile\u0219te singur\u0103 riscul de anafilaxie \u0219i nu \u00eenlocuie\u0219te consultul alergologic. Rezultatul poate \u00eens\u0103 ajuta medicul s\u0103 confirme sensibilizarea la veninul de albin\u0103 \u0219i s\u0103 stabileasc\u0103 recomand\u0103ri privind evitarea expunerii, conduita \u00een caz de \u00een\u021bep\u0103tur\u0103, necesitatea unui plan de urgen\u021b\u0103 sau evaluarea pentru imunoterapie cu venin, atunci c\u00e2nd este cazul.<\/p>\n<h2>2. Indica\u021bii testare<\/h2>\n<ul>\n<li>Evaluarea pacien\u021bilor care au prezentat reac\u021bii alergice dup\u0103 \u00een\u021bep\u0103tur\u0103 de albin\u0103, mai ales dac\u0103 manifest\u0103rile au fost extinse sau au afectat \u00eentregul organism;<\/li>\n<li>Investigarea reac\u021biilor sugestive pentru alergie la venin de albin\u0103, precum urticarie generalizat\u0103, m\u00e2nc\u0103rimi intense, umflarea fe\u021bei, buzelor, pleoapelor sau limbii, dificult\u0103\u021bi de respira\u021bie, respira\u021bie \u0219uier\u0103toare, ame\u021beal\u0103, stare de le\u0219in sau sc\u0103derea tensiunii arteriale;<\/li>\n<li>Evaluarea pacien\u021bilor cu suspiciune de anafilaxie dup\u0103 \u00een\u021bep\u0103tur\u0103 de albin\u0103<\/li>\n<li>Clarificarea sensibiliz\u0103rii la venin de albin\u0103 atunci c\u00e2nd istoricul este sugestiv, dar rezultatele alergologice sunt dificil de interpretat;<\/li>\n<li>Diferen\u021bierea sensibiliz\u0103rii la venin de albin\u0103 de sensibilizarea la alte veninuri de himenoptere, precum veninul de viespe, mai ales atunci c\u00e2nd testele pentru extracte totale sunt pozitive pentru mai multe insecte;<\/li>\n<li>Completarea diagnosticului alergologic molecular la pacien\u021bii cu suspiciune de alergie la venin de albin\u0103;<\/li>\n<li>Completarea evalu\u0103rii alergologice la pacien\u021bii pentru care se ia \u00een considerare imunoterapia cu venin, atunci c\u00e2nd caracterizarea molecular\u0103 a sensibiliz\u0103rii este relevant\u0103.<\/li>\n<\/ul>\n<h2><span style=\"color: #e67e23\">3. Preg\u0103tire pacient \u0219i mod de recoltare<\/span><\/h2>\n<ul>\n<li>Nu este necesar\u0103, \u00een general, o preg\u0103tire alimentar\u0103 special\u0103. Dac\u0103 analiza este recoltat\u0103 \u00eempreun\u0103 cu alte teste, se respect\u0103 condi\u021biile de preg\u0103tire indicate pentru acestea \u0219i instruc\u021biunile laboratorului.<\/li>\n<li>Tratamentul prescris se continu\u0103, dac\u0103 medicul nu indic\u0103 altfel.<\/li>\n<li>Este important ca medicul s\u0103 fie informat despre reac\u021bia ap\u0103rut\u0103 dup\u0103 \u00een\u021bep\u0103tur\u0103, momentul apari\u021biei simptomelor, severitatea manifest\u0103rilor, insecta suspectat\u0103, tratamentul administrat, antecedentele de anafilaxie, astm, alte alergii sau tratamente alergologice anterioare.<\/li>\n<li>Dac\u0103 analiza este recomandat\u0103 dup\u0103 o reac\u021bie alergic\u0103 sever\u0103, momentul optim al test\u0103rii trebuie stabilit de medicul alergolog, \u00een func\u021bie de contextul clinic. Dac\u0103 testarea efectuat\u0103 foarte precoce dup\u0103 reac\u021bie este negativ\u0103, medicul poate recomanda repetarea ei dup\u0103 c\u00e2teva s\u0103pt\u0103m\u00e2ni<\/li>\n<li>Rezultatul trebuie interpretat \u00een context clinic. Un rezultat pozitiv indic\u0103 sensibilizare la rApi m 1, dar nu confirm\u0103 singur c\u0103 veninul de albin\u0103 este cauza reac\u021biei.<\/li>\n<\/ul>\n<h2><span style=\"color: #e67e23\">4. Tipul probei recoltate<\/span><\/h2>\n<ul>\n<li>S\u00e2nge venos<\/li>\n<\/ul>\n<h2><span style=\"color: #e67e23\">5. Valori de referin\u021b\u0103<\/span><\/h2>\n<p>Valorile pot varia \u00een func\u021bie de laborator \u0219i de metoda utilizat\u0103.<\/p>\n<ul>\n<li><strong>Rezultat negativ:<\/strong> anticorpi IgE specifici nedetectabili sau sub limita de referin\u021b\u0103 a laboratorului.<\/li>\n<li><strong>Rezultat pozitiv:<\/strong> anticorpi IgE specifici detectabili fa\u021b\u0103 de rApi m 1 \u2013 fosfolipaza A2 din veninul de albin\u0103.<\/li>\n<\/ul>\n<p>\u00cen multe laboratoare, rezultatul este exprimat cantitativ, \u00een kUA\/L, \u0219i\/sau \u00eencadrat pe clase de reactivitate. Interpretarea trebuie f\u0103cut\u0103 \u00een func\u021bie de intervalele comunicate pe buletinul de analiz\u0103.<\/p>\n<h2><span style=\"color: #e67e23\">6. Interpretare rezultate<\/span><\/h2>\n<h3>Rezultat negativ<\/h3>\n<ul>\n<li>Nu eviden\u021biaz\u0103 o sensibilizare IgE detectabil\u0103 fa\u021b\u0103 de rApi m 1 prin metoda utilizat\u0103.<\/li>\n<li>Nu exclude complet alergia la venin de albin\u0103, deoarece unii pacien\u021bi pot fi sensibiliza\u021bi la alte componente ale veninului, diferite de Api m 1.<\/li>\n<li>Dac\u0103 istoricul de reac\u021bie dup\u0103 \u00een\u021bep\u0103tur\u0103 este sugestiv, medicul poate recomanda testarea IgE fa\u021b\u0103 de extractul total de venin de albin\u0103, alte componente moleculare ale veninului sau teste alergologice suplimentare.<\/li>\n<\/ul>\n<h3>Rezultat pozitiv \/ anticorpi IgE specifici detecta\u021bi peste pragul de pozitivitate al metodei<\/h3>\n<ul>\n<li>Indic\u0103 prezen\u021ba anticorpilor IgE specifici fa\u021b\u0103 de rApi m 1.<\/li>\n<li>Sus\u021bine sensibilizarea fa\u021b\u0103 de veninul de albin\u0103, mai ales dac\u0103 pacientul a avut simptome dup\u0103 o \u00een\u021bep\u0103tur\u0103 de albin\u0103.<\/li>\n<li>Poate ajuta la diferen\u021bierea sensibiliz\u0103rii la venin de albin\u0103 de sensibilizarea la venin de viespe, mai ales la pacien\u021bii cu rezultate pozitive la mai multe veninuri.<\/li>\n<li>Poate contribui la caracterizarea profilului molecular de sensibilizare la pacien\u021bii la care imunoterapia cu venin este luat\u0103 \u00een considerare pe baza tabloului clinic.<\/li>\n<\/ul>\n<p><strong>Important<\/strong>: valoarea IgE specific\u0103 nu se coreleaz\u0103 \u00eentotdeauna direct cu severitatea reac\u021biei. Un rezultat pozitiv trebuie interpretat \u00eempreun\u0103 cu istoricul pacientului, tipul reac\u021biei dup\u0103 \u00een\u021bep\u0103tur\u0103 \u0219i evaluarea medicului alergolog.<\/p>\n<h2><span style=\"color: #e67e23\">7. Factori care pot influen\u021ba rezultatul<\/span><\/h2>\n<p>Factorul principal este momentul test\u0103rii \u2013 un test efectuat prea cur\u00e2nd dup\u0103 reac\u021bia alergic\u0103 (dup\u0103 \u00een\u021bep\u0103tur\u0103) poate avea un rezultat negativ. Dac\u0103 simptomele \u0219i istoricul sugereaz\u0103 o alergie la venin de albin\u0103, medicul poate recomanda repetarea analizei dup\u0103 c\u00e2teva s\u0103pt\u0103m\u00e2ni.\u00a0<\/p>\n<h2><span style=\"color: #e67e23\">8. Analize complementare<\/span><\/h2>\n<ul>\n<li><strong>IgE specific la venin de albine (i1)<\/strong> \u2013 util pentru evaluarea sensibiliz\u0103rii fa\u021b\u0103 de extractul total de venin de albin\u0103, mai ales atunci c\u00e2nd se dore\u0219te corelarea rezultatului molecular cu reac\u021bia clinic\u0103 dup\u0103 \u00een\u021bep\u0103tur\u0103;<\/li>\n<li><strong>IgE specific la venin de albin\u0103 rApi m 10 \u2013 Icarapin (i217)<\/strong> \u2013 util pentru completarea diagnosticului molecular al alergiei la venin de albin\u0103, mai ales atunci c\u00e2nd este necesar\u0103 evaluarea mai detaliat\u0103 a profilului de sensibilizare;<\/li>\n<li><strong>IgE specific la venin de viespe comun\u0103 (Vespula) (i3)<\/strong> \u2013 util pentru evaluarea sensibiliz\u0103rii fa\u021b\u0103 de extractul total de venin de viespe comun\u0103, mai ales la pacien\u021bii la care insecta responsabil\u0103 pentru reac\u021bie nu este clar identificat\u0103;<\/li>\n<li><strong>IgE specific la venin de viespe comun\u0103 (antigen recombinant rVes v 1, fosfolipaza A1) (i211)<\/strong> \u2013 util pentru evaluarea molecular\u0103 a sensibiliz\u0103rii la venin de viespe comun\u0103 \u0219i pentru diferen\u021bierea fa\u021b\u0103 de sensibilizarea la venin de albin\u0103;<\/li>\n<li><strong>IgE specific la venin de viespe comun\u0103 (antigen recombinant rVes v 5, antigen 5) (i209)<\/strong> \u2013 util pentru completarea diagnosticului molecular al alergiei la venin de viespe comun\u0103, \u00een special la pacien\u021bii cu suspiciune clinic\u0103 \u0219i profil alergologic complex;<\/li>\n<li><strong>IgE specific la venin de viespe de h\u00e2rtie (Polistes spp.) (i4)<\/strong> \u2013 util pentru evaluarea sensibiliz\u0103rii fa\u021b\u0103 de veninul de viespe de h\u00e2rtie, \u00een cazurile \u00een care istoricul sugereaz\u0103 o posibil\u0103 reac\u021bie la acest tip de insect\u0103;<\/li>\n<li><strong>IgE specific la viespe european\u0103 (Vespa crabro) (i75)<\/strong> \u2013 util pentru evaluarea sensibiliz\u0103rii fa\u021b\u0103 de veninul de viespe european\u0103, mai ales la pacien\u021bii cu reac\u021bii dup\u0103 \u00een\u021bep\u0103turi de himenoptere \u0219i insect\u0103 responsabil\u0103 incert\u0103;<\/li>\n<li><strong>Triptaza seric\u0103 \u2013 <\/strong>poate fi indicat\u0103 \u00een evaluarea anafilaxiei, iar valoarea bazal\u0103 poate oferi informa\u021bii suplimentare privind activarea mastocitar\u0103 \u0219i anumi\u021bi factori de risc;<\/li>\n<li><strong>IgE seric<\/strong> \u2013 util pentru evaluarea nivelului total al imunoglobulinelor E, f\u0103r\u0103 a identifica \u00eens\u0103 alergenul responsabil;<\/li>\n<li><strong>Consult alergologic \u0219i, la indica\u021bia medicului, teste cutanate alergologice sau alte investiga\u021bii specifice<\/strong> \u2013 utile pentru corelarea rezultatelor de laborator cu istoricul reac\u021biei, insecta suspectat\u0103 \u0219i tabloul clinic.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Testul detecteaz\u0103 anticorpii IgE specifici fa\u021b\u0103 de rApi m 1, fosfolipaza A2, una dintre componentele alergene majore ale veninului de albin\u0103. Este util \u00een evaluarea reac\u021biilor alergice ap\u0103rute dup\u0103 \u00een\u021bep\u0103tura de albin\u0103 \u0219i \u00een caracterizarea sensibiliz\u0103rii la acest tip de venin.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"product_brand":[],"product_cat":[3151,1209,2876],"product_tag":[4727,4720,4717,4716,4024,4721,4719,4725,4724,4715,4713,4726,4714,4722,4697,4723,4718],"class_list":["post-128743","product","type-product","status-publish","product_cat-alergologie","product_cat-analize","product_cat-serviciu-laborator","product_tag-alergie-albine","product_tag-alergie-himenoptere","product_tag-alergie-la-intepatura-de-albina","product_tag-alergie-la-venin-de-albina","product_tag-alergolog","product_tag-anafilaxie","product_tag-apis-mellifera","product_tag-diagnostic-molecular-alergii","product_tag-dificultati-de-respiratie-dupa-intepatura","product_tag-fosfolipaza-a2","product_tag-ige-specific-venin-de-albina","product_tag-imunoterapie-cu-venin","product_tag-rapi-m-1","product_tag-reactie-alergica-la-intepatura","product_tag-sensibilizare-ige","product_tag-urticarie-generalizata","product_tag-venin-de-albine","first","instock","sale","shipping-taxable","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Testul detecteaz\u0103 anticorpii IgE specifici fa\u021b\u0103 de rApi m 1, fosfolipaza A2, una dintre componentele alergene majore ale veninului de albin\u0103. Este util \u00een evaluarea reac\u021biilor alergice ap\u0103rute dup\u0103 \u00een\u021bep\u0103tura de albin\u0103 \u0219i \u00een caracterizarea sensibiliz\u0103rii la acest tip de venin.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.clinica-sante.com\/ro\/analize-alergologie\/ige-specific-la-venin-de-albina-rapi-m1-fosfolipaza-a2-i208\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 5.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ro_RO\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Clinica Sante - Laborator de Analize Medicale - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"IgE specific la venin de albin\u0103 rApi m1 \u2013 fosfolipaza A2 (i208) - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta property=\"og:description\" content=\"Testul detecteaz\u0103 anticorpii IgE specifici fa\u021b\u0103 de rApi m 1, fosfolipaza A2, una dintre componentele alergene majore ale veninului de albin\u0103. Este util \u00een evaluarea reac\u021biilor alergice ap\u0103rute dup\u0103 \u00een\u021bep\u0103tura de albin\u0103 \u0219i \u00een caracterizarea sensibiliz\u0103rii la acest tip de venin.\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.clinica-sante.com\/ro\/analize-alergologie\/ige-specific-la-venin-de-albina-rapi-m1-fosfolipaza-a2-i208\/\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2026-09-14T09:36:28+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-10-21T16:43:53+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"IgE specific la venin de albin\u0103 rApi m1 \u2013 fosfolipaza A2 (i208) - Clinica Sante - Laborator de Analize Medicale\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Testul detecteaz\u0103 anticorpii IgE specifici fa\u021b\u0103 de rApi m 1, fosfolipaza A2, una dintre componentele alergene majore ale veninului de albin\u0103. 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