{"id":28806,"date":"2025-07-07T08:41:07","date_gmt":"2025-07-07T06:41:07","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/?p=28806"},"modified":"2026-03-20T10:35:48","modified_gmt":"2026-03-20T08:35:48","slug":"anemia-falciforma-siclemia-o-boala-genetica-a-sangelui-cu-implicatii-severe","status":"publish","type":"post","link":"https:\/\/www.clinica-sante.com\/ro\/anemia-falciforma-siclemia-o-boala-genetica-a-sangelui-cu-implicatii-severe\/","title":{"rendered":"Anemia falciform\u0103 (siclemia): o boal\u0103 genetic\u0103 a s\u00e2ngelui cu implica\u021bii severe"},"content":{"rendered":"
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Cuprins<\/p>\r\n <\/div>\r\n

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  1. \r\n Ce este anemia falciform\u0103?<\/a><\/span>\r\n <\/li>\r\n
  2. \r\n De ce apare?<\/a><\/span>\r\n <\/li>\r\n
  3. \r\n Manifest\u0103ri clinice<\/a><\/span>\r\n <\/li>\r\n
  4. \r\n Complica\u021bii posibile<\/a><\/span>\r\n <\/li>\r\n
  5. \r\n Investiga\u021bii diagnostice<\/a><\/span>\r\n <\/li>\r\n
  6. \r\n Concluzie<\/a><\/span>\r\n <\/li>\r\n <\/ol>\r\n <\/div>\r\n \r\n\n\n\n

    Anemia falciform\u0103<\/strong><\/span>, cunoscut\u0103 \u0219i sub numele de siclemie, este o boal\u0103 ereditar\u0103 a s\u00e2ngelui care afecteaz\u0103 forma \u0219i func\u021bia globulelor ro\u0219ii (hematiile\/ eritrocitele). Este o afec\u021biune grav\u0103, caracterizat\u0103 de manifest\u0103ri precum oboseal\u0103 persistent\u0103, durere, icter sau infec\u021bii frecvente \u0219i poate determina complica\u021bii severe, necesit\u00e2nd \u00eengrijire medical\u0103 atent\u0103.<\/p>\n<\/div>\n\n\n

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    \n 1.<\/span>\n Ce este anemia falciform\u0103?<\/span> <\/h2>\n<\/div>\n\n\n

    \u00cen mod normal, eritrocitele sunt celule rotunde, flexibile, ceea ce le permite s\u0103 circule u\u0219or prin vasele de s\u00e2nge, transport\u00e2nd oxigen c\u0103tre organe \u0219i \u021besuturi. La persoanele cu siclemie, din cauza unei muta\u021bii genetice, globulele ro\u0219ii cap\u0103t\u0103 o form\u0103 anormal\u0103, asem\u0103n\u0103toare literei \u201cC\u201d sau unei seceri (de unde \u0219i numele afec\u021biunii \u2013 „falx”, \u00een latin\u0103, \u00eenseamn\u0103 secer\u0103). <\/p>\n

    Aceste celule sunt rigide \u0219i lipicioase \u0219i se blocheaz\u0103 u\u0219or \u00een special \u00een vasele mici de s\u00e2nge, ceea ce \u00eempiedic\u0103 oxigenarea corespunz\u0103toare a \u021besuturilor, provoc\u00e2nd inflama\u021bie \u0219i durere. De asemenea, ele au o durat\u0103 de via\u021b\u0103 mai scurt\u0103, ceea ce determin\u0103 anemie sever\u0103 \u0219i alte complica\u021bii.<\/p>\n<\/div>\n\n\n

    \n sus<\/span>\n<\/div>\n\n\n
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    \n 2.<\/span>\n De ce apare?<\/span> <\/h2>\n<\/div>\n\n\n
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    \n \n \n <\/svg>\n <\/div>\n
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    <\/h2>\n

    Anemia falciform\u0103<\/strong><\/span> este o boal\u0103 genetic\u0103 ereditar\u0103 (mo\u0219tenit\u0103 de la p\u0103rin\u021bi), caracterizat\u0103 printr-o muta\u021bie la nivelul genei hemoglobinei, proteina din globulele ro\u0219ii care ajut\u0103 la transportul oxigenului. Ea apare atunci c\u00e2nd copilul prime\u0219te dou\u0103 copii ale genei afectate, una de la fiecare p\u0103rinte.<\/p>\n

    Dac\u0103 o persoan\u0103 mo\u0219tene\u0219te doar o gen\u0103 cu muta\u021bia este considerat\u0103 purt\u0103toare \u0219i, de obicei, nu dezvolt\u0103 simptome grave, \u00eens\u0103 poate transmite gena copiilor.
    \n\u00cen Rom\u00e2nia, cazurile de siclemie sunt rare, aceasta fiind frecvent\u0103 \u00een special \u00een unele regiuni din Africa.<\/p>\n<\/p>\n <\/div>\n<\/div>\n\n\n\n

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    \n 3.<\/span>\n Manifest\u0103ri clinice<\/span> <\/h2>\n<\/div>\n\n\n

    Semnele \u0219i simptomele anemiei falciforme pot varia de la u\u0219oare la severe \u0219i apar de obicei devreme, \u00eenc\u0103 din copil\u0103rie, \u00eencep\u00e2nd cu v\u00e2rsta de 6-9 luni. Cele mai frecvente manifest\u0103ri includ:<\/p>\n<\/div>\n\n\n\n

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