{"id":25629,"date":"2025-06-05T14:38:55","date_gmt":"2025-06-05T12:38:55","guid":{"rendered":"https:\/\/www.clinica-sante.com\/ro\/?p=25629"},"modified":"2026-03-20T11:03:21","modified_gmt":"2026-03-20T09:03:21","slug":"testarea-kir-si-a-hla-c-2","status":"publish","type":"post","link":"https:\/\/www.clinica-sante.com\/ro\/testarea-kir-si-a-hla-c-2\/","title":{"rendered":"Testarea KIR \u0219i a HLA-C"},"content":{"rendered":"
\r\n
\r\n

Cuprins<\/p>\r\n <\/div>\r\n

    \r\n
  1. \r\n R\u0103spunsul alo-imun la HLA-C patern are un rol important \u00een declan\u0219area de:<\/a><\/span>\r\n <\/li>\r\n
  2. \r\n Analize disponibile:<\/a><\/span>\r\n <\/li>\r\n <\/ol>\r\n <\/div>\r\n \r\n\n\n\n

    Succesul reproductiv uman \u0219i \u00een spe\u021b\u0103 mecanismul de recunoa\u0219tere alogenic\u0103 \u00een sarcin\u0103 depinde de interac\u021biunea dintre membrii familiei de receptori exprima\u021bi de celulele NK uterine numi\u021bi KIR<\/span> <\/strong>(Killer Imunoglobulin-like Receptor) \u0219i epitopii HLA-C<\/span><\/strong> (Human Leukocyte Antigen-C) exprima\u021bi de trophoblast. <\/span><\/p>\n

    \u00cen primul trimestru de sarcin\u0103, celulele NK din endometru (celule NK deciduale) sunt predominante \u0219i reprezint\u0103 popula\u021bia celular\u0103 dominant\u0103 (aproximativ 70% din totalul popula\u021biei de leucocite din mucoasa uterin\u0103).<\/p>\n

    Sunt 14 gene KIR \u0219i 2 pseudogene,<\/strong> <\/span>iar celulele umane NK exprim\u0103diverse combina\u021bii ale acestor gene \u00eempar\u021bite \u00een 2 haplotipuri: <\/span><\/span><\/p>\n<\/div>\n\n\n\n

    \n