{"id":11515,"date":"2023-04-07T02:39:18","date_gmt":"2023-04-07T02:39:18","guid":{"rendered":"https:\/\/www.clinica-sante.ro\/?p=11515"},"modified":"2026-03-20T14:58:07","modified_gmt":"2026-03-20T12:58:07","slug":"detectia-mutatiilor-in-genele-all-ras-kras-si-nras-in-cancerul-colorectal-crc","status":"publish","type":"post","link":"https:\/\/www.clinica-sante.com\/ro\/detectia-mutatiilor-in-genele-all-ras-kras-si-nras-in-cancerul-colorectal-crc\/","title":{"rendered":"Detec\u021bia muta\u021biilor \u00een genele All RAS (KRAS \u0219i NRAS) \u00een cancerul colorectal (CRC)"},"content":{"rendered":"<p style=\"font-weight: 400\">Aproximativ 52% dintre CRC sporadice sunt asociate cu muta\u021biile \u00een genele din familia RAS (KRAS \u0219i NRAS=All RAS).<\/p>\n<h4 style=\"font-weight: 400\"><strong>Testarea molecular\u0103 CRC<\/strong><\/h4>\n<p style=\"font-weight: 400\">Conform ghidurilor NCCN (National Comprehensive Cancer Network), testarea RAS trebuie acordat\u0103 tuturor pacien\u021bilor cu CRC \u00een stadiu avansat sau metastatic (grup \u021binta) \u0219i s\u0103 includ\u0103 exonii 2, 3 \u0219i 4 ai genelor KRAS \u0219i NRAS (testare RAS extins\u0103).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-12535 size-full\" src=\"https:\/\/www.clinica-sante.ro\/wp-content\/uploads\/2023\/04\/WhatsApp-Image-2023-06-22-at-11.37.35.jpeg\" alt=\"Detec\u021bia muta\u021biilor \u00een genele All RAS (KRAS \u0219i NRAS) \u00een cancerul colorectal (CRC)\" width=\"940\" height=\"360\" \/><\/p>\n<hr \/>\n<p style=\"font-weight: 400\"><em><span style=\"color: #f58220\"><strong>Tip prob\u0103<\/strong>\u00a0<\/span>&#8211; Bloc de \u021besut inclus \u00een parafin\u0103 \u00eenso\u021bit de buletin HP, IHC si lame HE &#8211; nu necesit\u0103 condi\u021bii speciale de transport.<\/em><\/p>\n<p style=\"font-weight: 400\"><em><strong><span style=\"color: #f58220\">Tip analiz\u0103 <\/span><\/strong>&#8211; Real-Time PCR \u00een 2 etape, conform algoritmului &#8222;\u00een cascad\u0103&#8221;:<\/em><\/p>\n<ol>\n<li><em>Screening-ul exonului 2, codonii 12 si 13, gena KRAS; absen\u021ba muta\u021biilor &#8211; indiciu pentru etapa a 2-a a analizei<\/em><\/li>\n<li style=\"font-weight: 400\"><em>Testarea extins\u0103 All RAS &#8211; exonii 3 \u0219i 4 ai genei KRAS \u0219i 2, 3 \u0219i 4 ai genei NRAS<\/em><\/li>\n<\/ol>\n<hr \/>\n<p style=\"font-weight: 400\"><span style=\"color: #f58220\"><strong>Muta\u021biile All RAS<\/strong> <span style=\"color: #000000\">&#8211;<\/span> <strong>detectate<\/strong> <\/span>&#8211; indicator al rezistentei primare la terapia cu anticorpi monoclonali (Amo) anti-EGFR (Epidermal Growth Factor Receptor)<\/p>\n<p style=\"font-weight: 400\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 &#8211; <span style=\"color: #f58220\"><strong>nedetectate (wild-type) <\/strong><\/span>&#8211; indicator pentru terapia cu Amo anti-EGFR<\/p>\n\n\n<div  class=\"bloc_description_section\"><p>Detec\u021bia muta\u021biilor \u00een genele ALL RAS, exonii 2, 3 \u0219i 4 (codonii 12, 13, 59, 61, 117 si 146) \u00een cancerul colorectal \u2013 35 muta\u021bii (\u021besut inclus \u00een parafin\u0103)<\/p>\n<p>Detec\u021bia muta\u021biilor \u00een gena K RAS, exonii 2, 3 \u0219i 4 (codonii 12, 13, 59, 61, 117 \u0219i 146) \u00een cancerul colorectal \u2013 21 muta\u021bii (\u021besut inclus \u00een parafin\u0103)<\/p>\n<p>Detec\u021bia muta\u021biilor \u00een gena K RAS, exonul 2 (codonii 12 \u0219i 13) \u00een cancerul colorectal \u2013 7 muta\u021bii (\u021besut inclus \u00een parafin\u0103)<\/p>\n<p>Detec\u021bia muta\u021biilor \u00een gena N RAS, exonii 2, 3 si 4 (codonii 12, 13, 59, 61, 117 \u0219i 146) \u00een cancerul colorectal \u2013 14 muta\u021bii (\u021besut inclus \u00een parafin\u0103)<\/p>\n<p>Detec\u021bia muta\u021biilor \u00een gena N RAS, exonii 2, 3 \u0219i 4 (codonii 12, 13, 59, 61, 117 \u0219i 146) \u00een melanom \u2013 14 muta\u021bii (\u021besut inclus \u00een parafin\u0103)<\/p>\n<p><span style=\"color: #f58220\">Investiga\u021biile comandate online sunt supuse unei <strong>reduceri de 12%<\/strong> fa\u021b\u0103 de pre\u021bul de catalog.<\/span><\/p>\n<\/div>\n\n<section class=\"section_carusel_produse\">\n    <div class=\"container\">\n        <div class=\"splide splide-carousel-guttenberg\">\n            <div class=\"splide__track\">\n                <ul class=\"splide__list\">\n                                                        <li class=\"splide__slide\">\n                                        <div class=\"product prod\">\n                                                                                             <div class=\"loop-product-discount\">-12%<\/div>                                                                                        <a title=\"Detectia mutatiilor in genele ALL RAS, exonii 2, 3 si 4 (codonii 12, 13, 59, 61, 117 si 146) in cancerul colorectal \u2013 35 mutatii (tesut inclus in parafina)\"\n                                                href=\"https:\/\/www.clinica-sante.com\/ro\/analize-oncogenetica\/detectia-mutatiilor-in-genele-all-ras-exonii-2-3-si-4-codonii-12-13-59-61-117-si-146-in-cancerul-colorectal-35-mutatii-tesut-inclus-in-parafina\/\"\n                                                class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n                                                <h4 class=\"woocommerce-loop-product__title\">\n                                                    Detectia mutatiilor in genele ALL RAS, exonii 2&#8230;                                                <\/h4>\n                                            <\/a>\n                                            <div class=\"loop-product-wrapper\">\n                                                <div class=\"loop-product-prices\">\n                                                    <del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi>1.700,00&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Pre\u021bul ini\u021bial a fost: 1.700,00&nbsp;lei.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi>1.496,00&nbsp;<span class=\"woocommerce-Price-currencySymbol\">lei<\/span><\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Pre\u021bul curent este: 1.496,00&nbsp;lei.<\/span>                                                <\/div>\n                                            <\/div>\n                                                    <div class=\"loop-product-footer\" id=\"identificator_list_prod_27618\"\n            data-prod-title=\"Detectia mutatiilor in genele ALL RAS, exonii 2, 3 si 4 (codonii 12, 13, 59, 61, 117 si 146) in cancerul colorectal \u2013 35 mutatii (tesut inclus in parafina)\"\n            data-prod-sku=\"7629\">\n\n            \n<div\n\tclass=\"yith-wcwl-add-to-wishlist add-to-wishlist-27618 yith-wcwl-add-to-wishlist--link-style wishlist-fragment on-first-load\"\n\tdata-fragment-ref=\"27618\"\n\tdata-fragment-options=\"{&quot;base_url&quot;:&quot;&quot;,&quot;product_id&quot;:27618,&quot;parent_product_id&quot;:0,&quot;product_type&quot;:&quot;simple&quot;,&quot;is_single&quot;:false,&quot;in_default_wishlist&quot;:false,&quot;show_view&quot;:false,&quot;browse_wishlist_text&quot;:&quot;&quot;,&quot;already_in_wishslist_text&quot;:&quot;Produsul este deja in lista de favorite&quot;,&quot;product_added_text&quot;:&quot;Produs ad\\u0103ugat \\u00een lista de favorite&quot;,&quot;available_multi_wishlist&quot;:false,&quot;disable_wishlist&quot;:false,&quot;show_count&quot;:false,&quot;ajax_loading&quot;:false,&quot;loop_position&quot;:&quot;shortcode&quot;,&quot;item&quot;:&quot;add_to_wishlist&quot;}\"\n>\n\t<\/div>\n<div class=\"add-to-cart-container mt-auto\"><a href=\"\/ro\/wp-json\/wp\/v2\/posts\/11515?add-to-cart=27618\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart comandaButton\" product-title=\"Detectia mutatiilor in genele ALL RAS, exonii 2, 3 si 4 (codonii 12, 13, 59, 61, 117 si 146) in cancerul colorectal \u2013 35 mutatii (tesut inclus in parafina)\" data-product_id=\"27618\" data-product_category=\"Analize\" data-product_subcategory=\"Oncogenetica; Serviciu laborator\" data-product_sku=\"7629\" aria-label=\"Adaug\u0103 \u00een co\u0219: &amp;lbquo;Detectia mutatiilor in genele ALL RAS, exonii 2, 3 si 4 (codonii 12, 13, 59, 61, 117 si 146) in cancerul colorectal \u2013 35 mutatii (tesut inclus in parafina)&rdquo;\" rel=\"nofollow\" regular_price=\"1700\" sale_price=\"1496\" discount_difference=\"204\"><div class=\"btn-loader\"><span class=\"spinner-border spinner-border-sm\"><\/span><\/div>Adaug\u0103 \u00een co\u0219 <svg width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                            <path d=\"M12.8 12.8C11.912 12.8 11.2 13.512 11.2 14.4C11.2 14.8243 11.3686 15.2313 11.6686 15.5314C11.9687 15.8314 12.3757 16 12.8 16C13.2243 16 13.6313 15.8314 13.9314 15.5314C14.2314 15.2313 14.4 14.8243 14.4 14.4C14.4 13.9757 14.2314 13.5687 13.9314 13.2686C13.6313 12.9686 13.2243 12.8 12.8 12.8ZM0 0V1.6H1.6L4.48 7.672L3.392 9.632C3.272 9.856 3.2 10.12 3.2 10.4C3.2 10.8243 3.36857 11.2313 3.66863 11.5314C3.96869 11.8314 4.37565 12 4.8 12H14.4V10.4H5.136C5.08296 10.4 5.03209 10.3789 4.99458 10.3414C4.95707 10.3039 4.936 10.253 4.936 10.2C4.936 10.16 4.944 10.128 4.96 10.104L5.68 8.8H11.64C12.24 8.8 12.768 8.464 13.04 7.976L15.904 2.8C15.96 2.672 16 2.536 16 2.4C16 2.18783 15.9157 1.98434 15.7657 1.83431C15.6157 1.68429 15.4122 1.6 15.2 1.6H3.368L2.616 0M4.8 12.8C3.912 12.8 3.2 13.512 3.2 14.4C3.2 14.8243 3.36857 15.2313 3.66863 15.5314C3.96869 15.8314 4.37565 16 4.8 16C5.22435 16 5.63131 15.8314 5.93137 15.5314C6.23143 15.2313 6.4 14.8243 6.4 14.4C6.4 13.9757 6.23143 13.5687 5.93137 13.2686C5.63131 12.9686 5.22435 12.8 4.8 12.8Z\" fill=\"white\"><\/path>\n                        <\/svg><\/a><\/a><\/div>        <\/div>\n                                                <\/div>\n                                    <\/li>\n                                               <\/ul>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n<div class=\"bgOrange bloc_title_section\">\n    <div class=\"m-3\">\n     <div class=\"row\">\n        <div class=\"col-md-3 col-lg-2 borderMap \">\n        <div class=\" leftBox\">\n                <div class=\"flexMob\">\n            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"61\" height=\"61\" viewBox=\"0 0 61 61\" fill=\"none\">\n            <g clip-path=\"url(#clip0_15501_13162)\">\n                <path d=\"M53.8333 0.260742H7.16667C3.5 0.260742 0.533333 3.26074 0.533333 6.92741L0.5 53.5941C0.5 57.2607 3.5 60.2607 7.16667 60.2607H53.8333C57.5 60.2607 60.5 57.2607 60.5 53.5941V6.92741C60.5 3.26074 57.5 0.260742 53.8333 0.260742ZM47.1667 36.9274H37.1667V46.9274C37.1667 48.7607 35.6667 50.2607 33.8333 50.2607H27.1667C25.3333 50.2607 23.8333 48.7607 23.8333 46.9274V36.9274H13.8333C12 36.9274 10.5 35.4274 10.5 33.5941V26.9274C10.5 25.0941 12 23.5941 13.8333 23.5941H23.8333V13.5941C23.8333 11.7607 25.3333 10.2607 27.1667 10.2607H33.8333C35.6667 10.2607 37.1667 11.7607 37.1667 13.5941V23.5941H47.1667C49 23.5941 50.5 25.0941 50.5 26.9274V33.5941C50.5 35.4274 49 36.9274 47.1667 36.9274Z\" fill=\"white\"\/>\n            <\/g>\n            <defs>\n                <clipPath id=\"clip0_15501_13162\">\n                <rect width=\"60\" height=\"60\" fill=\"white\" transform=\"translate(0.5 0.260742)\"\/>\n                <\/clipPath>\n            <\/defs>\n            <\/svg>\n        <\/div>\n        <p class=\"text-white textMap\">\n            Centre de <br> recoltare                            \n        <\/p>\n        <\/div>\n    <\/div>\n    <div class=\"col-md-8 col-lg-9\">\n        <div class=\"marginDekstop\">\n      <h2 class=\"text-white mb-4\">Sun\u0103 acum la num\u0103rul scurt *8787, alege centrul de recoltare cel mai apropiat \u0219i programeaz\u0103-te pentru efectuarea analizelor. Un gest simplu care poate face o mare diferen\u021b\u0103!<\/h2>\n\n     <p class=\"text-white mb-4\">Peste 300 de centre proprii de recoltare, \u00een toate jude\u021bele \u021b\u0103rii<\/p>\n          <a href=\"https:\/\/www.clinica-sante.com\/ro\/locatii\" class=\"buttonCentre\">\n                Vezi harta loca\u021biilor\n            <i class=\"fa-solid fa-caret-right\"><\/i>\n         <\/a>\n    <\/div>\n<\/div>\n  <\/div>\n    <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Testarea molecular\u0103 CRC &#8211; Aproximativ 52% dintre CRC sporadice sunt asociate cu muta\u021biile \u00een genele din familia RAS (KRAS \u0219i NRAS=All RAS). Conform ghidurilor NCCN (National Comprehensive Cancer Network), testarea RAS trebuie acordat\u0103 tuturor pacien\u021bilor cu CRC \u00een stadiu avansat sau metastatic (grup \u021binta) \u0219i s\u0103 includ\u0103 exonii 2, 3 \u0219i 4 ai genelor KRAS si NRAS (testare RAS extins\u0103).<\/p>\n","protected":false},"author":1,"featured_media":14878,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[395,2811],"tags":[],"class_list":["post-11515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genetica-pe-intelesul-tau","category-zoom-medical"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/posts\/11515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/comments?post=11515"}],"version-history":[{"count":5,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/posts\/11515\/revisions"}],"predecessor-version":[{"id":29569,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/posts\/11515\/revisions\/29569"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/media\/14878"}],"wp:attachment":[{"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/media?parent=11515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/categories?post=11515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.clinica-sante.com\/ro\/wp-json\/wp\/v2\/tags?post=11515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}